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- W2023286871 abstract "Background/Purpose: Liquid ventilation is a promising therapy for respiratory failure. The effects of perfluorochemical on cardiac output have not been well described. The purpose of this study was to compare cerebral blood flow (QCAROTID) and cerebral metabolic rates (CMR) during conventional ventilation (CV) and partial liquid ventilation (PLV). Methods: Five 2-week-old lambs underwent tracheostomy and central venous, aortic, and postcerebral venous catheter placement. Doppler flow probes were placed around the common ovine trunk, and the lambs underwent CV for 1 hour. Ventilation was adjusted to maintain physiologic blood gases. Pre- and postcerebral blood gas, glucose, and lactate samples were obtained every 15 minutes. Perfluorodecalin then was instilled endotracheally. The lambs underwent 1 hour of PLV with similar sampling. Data were analyzed using the Wilcoxon matched pairs test, significance at P ≤.05. Results: The authors observed no difference in mean QCAROTID or carotid vascular resistance between CV and PLV (P =.35 and.34, respectively). The CMR of oxygen, glucose, and lactate were calculated using the Fick principle. CMR was unchanged between modes (P =.5). Conclusions: PLV did not adversely alter QCAROTID or CMR in lambs, implying that this mode of ventilation should be safe in neonatal patients at risk for neurologic injury. J Pediatr Surg 37:840-844. Copyright 2002, Elsevier Science (USA). All rights reserved." @default.
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- W2023286871 date "2002-06-01" @default.
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- W2023286871 title "Effects of partial liquid ventilation on cerebral blood flow and cerebral metabolism in neonatal lambs" @default.
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- W2023286871 doi "https://doi.org/10.1053/jpsu.2002.32884" @default.
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