FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023287456> ?p ?o ?g. }

• W2023287456 endingPage "1199" @default.
• W2023287456 startingPage "1186" @default.
• W2023287456 abstract "Aim: Rubiaceae is one of the largest families of plants and it includes the Jamaican genus Portlandia. This family has been used in several ethnomedicinal practices. Thus, in this study we investigated whether extracts of two species of Portlandia affect In vitro proliferation of breast cancer cells. Study Design: Metastatic (MDA-MB-231 and HeLa) cells were incubated in the absence or in the presence of Portlandia extracts. A human non-metastatic (MCF-10A) and normal (ATCC PCS-600-010) epithelial cell lines were used as control. Methodology: At the end of the study all cell lines were incubated with Portlandia extracts (-and its subfractions-) and then analyzed on proliferation, thymidine incorporation and mitogenic and survival signaling pathways on metastatic and non-metastatic cells. Results: It was found that Portlandia methanol extract inhibited proliferation of MDA-MB231 in a dose-dependent manner attenuating the phosphorylation of Erk1/2 and Akt1 Original Research Article European Journal of Medicinal Plants, 4(10): 1186-1199, 2014 1187 without affecting the proliferation of MCF-10A cells. [H] thymidine incorporation was also decreased by Portlandia methanol extract. This study suggests that Portlandia extracts selectively affected the proliferation of metastatic breast cancer cells through the modulation of Erk1/2 and Akt1 activities that play a critical role during cell survival and proliferation. Conclusion: Portlandia leaf extracts contain active compounds, which strongly repress cancer cell proliferation in a dose-dependent manner and selectively down-regulate phosphorylation of both Erk1/2 and Akt1 activities." @default.
• W2023287456 created "2016-06-24" @default.
• W2023287456 creator A5010900753 @default.
• W2023287456 creator A5021801309 @default.
• W2023287456 creator A5023361891 @default.
• W2023287456 creator A5027211706 @default.
• W2023287456 creator A5038929908 @default.
• W2023287456 creator A5069431230 @default.
• W2023287456 creator A5075842923 @default.
• W2023287456 creator A5089487126 @default.
• W2023287456 date "2014-01-10" @default.
• W2023287456 modified "2023-10-17" @default.
• W2023287456 title "Antiproliferative Effect of Portlandia Extracts and Their Fractions on Breast Cancer Cells" @default.
• W2023287456 cites W101685397 @default.
• W2023287456 cites W1496088695 @default.
• W2023287456 cites W1590344406 @default.
• W2023287456 cites W1605461436 @default.
• W2023287456 cites W1937169612 @default.
• W2023287456 cites W1985438986 @default.
• W2023287456 cites W2005279983 @default.
• W2023287456 cites W2011156926 @default.
• W2023287456 cites W2011826559 @default.
• W2023287456 cites W2014380213 @default.
• W2023287456 cites W2018852959 @default.
• W2023287456 cites W2037490361 @default.
• W2023287456 cites W2039112669 @default.
• W2023287456 cites W2042514640 @default.
• W2023287456 cites W2052846872 @default.
• W2023287456 cites W2062903064 @default.
• W2023287456 cites W2071906932 @default.
• W2023287456 cites W2081932329 @default.
• W2023287456 cites W2084312945 @default.
• W2023287456 cites W2086724435 @default.
• W2023287456 cites W2104115609 @default.
• W2023287456 cites W2105529705 @default.
• W2023287456 cites W2114941442 @default.
• W2023287456 cites W2116294450 @default.
• W2023287456 cites W2119955771 @default.
• W2023287456 cites W2121837006 @default.
• W2023287456 cites W2122193613 @default.
• W2023287456 cites W2128635872 @default.
• W2023287456 cites W2129597014 @default.
• W2023287456 cites W2137197237 @default.
• W2023287456 cites W2144812465 @default.
• W2023287456 cites W2158318124 @default.
• W2023287456 cites W2160093888 @default.
• W2023287456 cites W2169620942 @default.
• W2023287456 cites W2227796252 @default.
• W2023287456 cites W2409373306 @default.
• W2023287456 cites W31880688 @default.
• W2023287456 doi "https://doi.org/10.9734/ejmp/2014/10250" @default.
• W2023287456 hasPublicationYear "2014" @default.
• W2023287456 type Work @default.
• W2023287456 sameAs 2023287456 @default.
• W2023287456 citedByCount "1" @default.
• W2023287456 countsByYear W20232874562018 @default.
• W2023287456 crossrefType "journal-article" @default.
• W2023287456 hasAuthorship W2023287456A5010900753 @default.
• W2023287456 hasAuthorship W2023287456A5021801309 @default.
• W2023287456 hasAuthorship W2023287456A5023361891 @default.
• W2023287456 hasAuthorship W2023287456A5027211706 @default.
• W2023287456 hasAuthorship W2023287456A5038929908 @default.
• W2023287456 hasAuthorship W2023287456A5069431230 @default.
• W2023287456 hasAuthorship W2023287456A5075842923 @default.
• W2023287456 hasAuthorship W2023287456A5089487126 @default.
• W2023287456 hasBestOaLocation W20232874561 @default.
• W2023287456 hasConcept C121608353 @default.
• W2023287456 hasConcept C126322002 @default.
• W2023287456 hasConcept C143998085 @default.
• W2023287456 hasConcept C185592680 @default.
• W2023287456 hasConcept C502942594 @default.
• W2023287456 hasConcept C530470458 @default.
• W2023287456 hasConcept C556039675 @default.
• W2023287456 hasConcept C71924100 @default.
• W2023287456 hasConcept C86803240 @default.
• W2023287456 hasConceptScore W2023287456C121608353 @default.
• W2023287456 hasConceptScore W2023287456C126322002 @default.
• W2023287456 hasConceptScore W2023287456C143998085 @default.
• W2023287456 hasConceptScore W2023287456C185592680 @default.
• W2023287456 hasConceptScore W2023287456C502942594 @default.
• W2023287456 hasConceptScore W2023287456C530470458 @default.
• W2023287456 hasConceptScore W2023287456C556039675 @default.
• W2023287456 hasConceptScore W2023287456C71924100 @default.
• W2023287456 hasConceptScore W2023287456C86803240 @default.
• W2023287456 hasIssue "10" @default.
• W2023287456 hasLocation W20232874561 @default.
• W2023287456 hasOpenAccess W2023287456 @default.
• W2023287456 hasPrimaryLocation W20232874561 @default.
• W2023287456 hasRelatedWork W2014447844 @default.
• W2023287456 hasRelatedWork W2297592050 @default.
• W2023287456 hasRelatedWork W2365364931 @default.
• W2023287456 hasRelatedWork W2418638721 @default.
• W2023287456 hasRelatedWork W2748952813 @default.
• W2023287456 hasRelatedWork W2899084033 @default.
• W2023287456 hasRelatedWork W3130591221 @default.
• W2023287456 hasRelatedWork W3196332669 @default.
• W2023287456 hasRelatedWork W377899687 @default.
• W2023287456 hasRelatedWork W4365129602 @default.

• next