FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023288260> ?p ?o ?g. }

• W2023288260 endingPage "485" @default.
• W2023288260 startingPage "485" @default.
• W2023288260 abstract "All-trans retinoic acid-incorporated nanoparticles of deoxycholic acid-conjugated dextran for treatment of CT26 colorectal carcinoma cells Young Il Jeong,1,* Kyu Don Chung,2,* Da Hye Kim,3 Yoon Hyuk Kim,4 Yeon Soo Lee,5 Ki Choon Choi31Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea; 2Department of Anesthesiology and Pain Medicine, Catholic University, Seoul, South Korea; 3Grassland and Forage Research Center, Rural Development Administration, Cheonan, South Korea; 4Department of Mechanical Engineering, Kyung Hee University, Seoul, South Korea; 5Department of Biomedical Engineering, Catholic University of Daegu, Daegu, South Korea*These authors equally contributed to this workPurpose: All-trans retinoic acid (RA)-incorporated nanoparticles were prepared using deoxycholic acid-conjugated dextran (DexDA). Anticancer activity of RA-incorporated DexDA nanoparticles were tested in vitro and in vivo.Methods: RA-incorporated nanoparticles were prepared by dialysis. Antiproliferative and anti-invasive potential of RA-incorporated nanoparticles were studied using CT26 colorectal carcinoma cells.Results: RA-incorporated nanoparticles have small particle sizes of around 70–300 nm and spherical shapes. The higher drug-feeding ratio and higher substitution degree of deoxycholic acid in the conjugates resulted in higher drug contents, lower loading efficiency, and larger particle size. RA release rate became slower at higher drug contents and higher substitution degree of deoxycholic acid in the DexDA conjugates. The antiproliferation activity, anti-invasive activity, and matrix metalloproteinase 2 expression of RA-incorporated nanoparticles against CT26 cells in vitro was similar to RA. However, RA-incorporated nanoparticles had superior antimetastatic activity in an animal pulmonary metastatic model of CT26 cells compared to RA itself.Conclusion: RA-incorporated nanoparticles showed similar anticancer activity in vitro and superior antimetastatic activity in vivo in a pulmonary metastatic model of CT26 cells. We suggest that RA-incorporated nanoparticles are promising vehicles for efficient delivery of RA.Keywords: nanoparticle, dextran, deoxycholic acid, retinoic acid, cancer cell invasion" @default.
• W2023288260 created "2016-06-24" @default.
• W2023288260 creator A5042090068 @default.
• W2023288260 creator A5053300676 @default.
• W2023288260 creator A5055136874 @default.
• W2023288260 creator A5062507964 @default.
• W2023288260 creator A5062706195 @default.
• W2023288260 creator A5087783651 @default.
• W2023288260 date "2013-01-01" @default.
• W2023288260 modified "2023-09-25" @default.
• W2023288260 title "All-trans retinoic acid-incorporated nanoparticles of deoxycholic acid-conjugated dextran for treatment of CT26 colorectal carcinoma cells" @default.
• W2023288260 cites W1539454494 @default.
• W2023288260 cites W1554600230 @default.
• W2023288260 cites W1980847379 @default.
• W2023288260 cites W2001503472 @default.
• W2023288260 cites W2006036234 @default.
• W2023288260 cites W2012176374 @default.
• W2023288260 cites W2029749273 @default.
• W2023288260 cites W2034697702 @default.
• W2023288260 cites W2037715397 @default.
• W2023288260 cites W2046657068 @default.
• W2023288260 cites W2054749887 @default.
• W2023288260 cites W2059471958 @default.
• W2023288260 cites W2066521306 @default.
• W2023288260 cites W2069446399 @default.
• W2023288260 cites W2071765435 @default.
• W2023288260 cites W2082302082 @default.
• W2023288260 cites W2084723351 @default.
• W2023288260 cites W2085583717 @default.
• W2023288260 cites W2103832072 @default.
• W2023288260 cites W2109590329 @default.
• W2023288260 cites W2113314295 @default.
• W2023288260 cites W2134427544 @default.
• W2023288260 cites W2156463058 @default.
• W2023288260 cites W2326230252 @default.
• W2023288260 cites W2402530137 @default.
• W2023288260 cites W2413626681 @default.
• W2023288260 cites W2523530498 @default.
• W2023288260 doi "https://doi.org/10.2147/ijn.s40580" @default.
• W2023288260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3564475" @default.
• W2023288260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23390366" @default.
• W2023288260 hasPublicationYear "2013" @default.
• W2023288260 type Work @default.
• W2023288260 sameAs 2023288260 @default.
• W2023288260 citedByCount "9" @default.
• W2023288260 countsByYear W20232882602013 @default.
• W2023288260 countsByYear W20232882602014 @default.
• W2023288260 countsByYear W20232882602016 @default.
• W2023288260 countsByYear W20232882602019 @default.
• W2023288260 countsByYear W20232882602020 @default.
• W2023288260 countsByYear W20232882602021 @default.
• W2023288260 countsByYear W20232882602022 @default.
• W2023288260 countsByYear W20232882602023 @default.
• W2023288260 crossrefType "journal-article" @default.
• W2023288260 hasAuthorship W2023288260A5042090068 @default.
• W2023288260 hasAuthorship W2023288260A5053300676 @default.
• W2023288260 hasAuthorship W2023288260A5055136874 @default.
• W2023288260 hasAuthorship W2023288260A5062507964 @default.
• W2023288260 hasAuthorship W2023288260A5062706195 @default.
• W2023288260 hasAuthorship W2023288260A5087783651 @default.
• W2023288260 hasBestOaLocation W20232882601 @default.
• W2023288260 hasConcept C104317684 @default.
• W2023288260 hasConcept C112613896 @default.
• W2023288260 hasConcept C126322002 @default.
• W2023288260 hasConcept C15083742 @default.
• W2023288260 hasConcept C150903083 @default.
• W2023288260 hasConcept C155672457 @default.
• W2023288260 hasConcept C171250308 @default.
• W2023288260 hasConcept C178790620 @default.
• W2023288260 hasConcept C185592680 @default.
• W2023288260 hasConcept C192562407 @default.
• W2023288260 hasConcept C202751555 @default.
• W2023288260 hasConcept C207001950 @default.
• W2023288260 hasConcept C2779399885 @default.
• W2023288260 hasConcept C2780749602 @default.
• W2023288260 hasConcept C2781121885 @default.
• W2023288260 hasConcept C502942594 @default.
• W2023288260 hasConcept C521977710 @default.
• W2023288260 hasConcept C55493867 @default.
• W2023288260 hasConcept C71924100 @default.
• W2023288260 hasConcept C86803240 @default.
• W2023288260 hasConcept C98274493 @default.
• W2023288260 hasConceptScore W2023288260C104317684 @default.
• W2023288260 hasConceptScore W2023288260C112613896 @default.
• W2023288260 hasConceptScore W2023288260C126322002 @default.
• W2023288260 hasConceptScore W2023288260C15083742 @default.
• W2023288260 hasConceptScore W2023288260C150903083 @default.
• W2023288260 hasConceptScore W2023288260C155672457 @default.
• W2023288260 hasConceptScore W2023288260C171250308 @default.
• W2023288260 hasConceptScore W2023288260C178790620 @default.
• W2023288260 hasConceptScore W2023288260C185592680 @default.
• W2023288260 hasConceptScore W2023288260C192562407 @default.
• W2023288260 hasConceptScore W2023288260C202751555 @default.
• W2023288260 hasConceptScore W2023288260C207001950 @default.
• W2023288260 hasConceptScore W2023288260C2779399885 @default.
• W2023288260 hasConceptScore W2023288260C2780749602 @default.
• W2023288260 hasConceptScore W2023288260C2781121885 @default.
• W2023288260 hasConceptScore W2023288260C502942594 @default.

• next