FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023288727> ?p ?o ?g. }

• W2023288727 endingPage "193" @default.
• W2023288727 startingPage "185" @default.
• W2023288727 abstract "Dysadherin is a recently characterized cancer-associated cell membrane glycoprotein that has a crucial role to cell-cell adhesiveness. The aim of this study was to examine dysadherin expression in head and neck squamous cell carcinoma (HNSCC). A total of 108 tissue specimens of patients with HNSCC were examined using immunostaining for dysadherin, E-cadherin, and the specific lymphatic endothelium marker D2-40. We quantified dysadherin and E-cadherin expression, assessed intratumoral (ILD) and peritumoral lymphatic density (PLD), and examined the possible associations of all the above parameters with clinicopathologic features and outcome. Finally, we used double staining with dysadherin and D2-40 to examine the expression pattern of dysadherin simultaneously with the lymphovasculature environment of HNSCC. High dysadherin expression was correlated with higher clinical stage (chi2, P = 0.01), with the presence of lymph node metastasis at the time of diagnosis (chi2, P = 0.02), and with increased ILD (chi2, P = 0.001). We observed an impressive reverse association between increased dysadherin expression and decreased E-cadherin expression (chi2, P < 0.001). Surprisingly, dysadherin-positive cancer cells usually gathered around areas of high intratumoral lymphatic vessel concentration, surrounding and invading small intratumoral lymphatics. Higher clinical stage and increased dysadherin expression were found to be the only significant independent prognostic factors for overall survival (hazard ratio, 3.94; 95% confidence interval, 1.09-14.27 for clinical stage; hazard ratio, 3.92; 95% confidence interval, 1.46-10.51 for dysadherin). The loss of intercellular adhesiveness and increased dysadherin expression seems to be related to lymphangiogenesis in HNSCC, but this should be confirmed by additional studies. Dysadherin expression might be a promising prognostic marker for separation of patients at higher risk." @default.
• W2023288727 created "2016-06-24" @default.
• W2023288727 creator A5037765315 @default.
• W2023288727 creator A5048212045 @default.
• W2023288727 creator A5049533585 @default.
• W2023288727 creator A5060741440 @default.
• W2023288727 creator A5063689180 @default.
• W2023288727 creator A5064680548 @default.
• W2023288727 creator A5067544495 @default.
• W2023288727 date "2006-02-01" @default.
• W2023288727 modified "2023-10-02" @default.
• W2023288727 title "Dysadherin Expression in Head and Neck Squamous Cell Carcinoma" @default.
• W2023288727 cites W1969375436 @default.
• W2023288727 cites W1973422759 @default.
• W2023288727 cites W1994045147 @default.
• W2023288727 cites W1994242106 @default.
• W2023288727 cites W1998419385 @default.
• W2023288727 cites W2007562801 @default.
• W2023288727 cites W2013950588 @default.
• W2023288727 cites W2028896946 @default.
• W2023288727 cites W2034350373 @default.
• W2023288727 cites W2034794305 @default.
• W2023288727 cites W2036832661 @default.
• W2023288727 cites W2047437874 @default.
• W2023288727 cites W2053959232 @default.
• W2023288727 cites W2066061889 @default.
• W2023288727 cites W2082850153 @default.
• W2023288727 cites W2084255175 @default.
• W2023288727 cites W2086684264 @default.
• W2023288727 cites W2089028882 @default.
• W2023288727 cites W2104557476 @default.
• W2023288727 cites W2107704714 @default.
• W2023288727 cites W2115867454 @default.
• W2023288727 cites W2118158719 @default.
• W2023288727 cites W2129686681 @default.
• W2023288727 doi "https://doi.org/10.1097/01.pas.0000178090.54147.f8" @default.
• W2023288727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16434892" @default.
• W2023288727 hasPublicationYear "2006" @default.
• W2023288727 type Work @default.
• W2023288727 sameAs 2023288727 @default.
• W2023288727 citedByCount "41" @default.
• W2023288727 countsByYear W20232887272012 @default.
• W2023288727 countsByYear W20232887272014 @default.
• W2023288727 countsByYear W20232887272015 @default.
• W2023288727 countsByYear W20232887272016 @default.
• W2023288727 countsByYear W20232887272017 @default.
• W2023288727 countsByYear W20232887272019 @default.
• W2023288727 countsByYear W20232887272020 @default.
• W2023288727 countsByYear W20232887272021 @default.
• W2023288727 countsByYear W20232887272022 @default.
• W2023288727 crossrefType "journal-article" @default.
• W2023288727 hasAuthorship W2023288727A5037765315 @default.
• W2023288727 hasAuthorship W2023288727A5048212045 @default.
• W2023288727 hasAuthorship W2023288727A5049533585 @default.
• W2023288727 hasAuthorship W2023288727A5060741440 @default.
• W2023288727 hasAuthorship W2023288727A5063689180 @default.
• W2023288727 hasAuthorship W2023288727A5064680548 @default.
• W2023288727 hasAuthorship W2023288727A5067544495 @default.
• W2023288727 hasConcept C121608353 @default.
• W2023288727 hasConcept C126322002 @default.
• W2023288727 hasConcept C142724271 @default.
• W2023288727 hasConcept C181152851 @default.
• W2023288727 hasConcept C204232928 @default.
• W2023288727 hasConcept C207103383 @default.
• W2023288727 hasConcept C2776530083 @default.
• W2023288727 hasConcept C2776636583 @default.
• W2023288727 hasConcept C2776833033 @default.
• W2023288727 hasConcept C2779013556 @default.
• W2023288727 hasConcept C2780849966 @default.
• W2023288727 hasConcept C2780965494 @default.
• W2023288727 hasConcept C4224716 @default.
• W2023288727 hasConcept C44249647 @default.
• W2023288727 hasConcept C71924100 @default.
• W2023288727 hasConceptScore W2023288727C121608353 @default.
• W2023288727 hasConceptScore W2023288727C126322002 @default.
• W2023288727 hasConceptScore W2023288727C142724271 @default.
• W2023288727 hasConceptScore W2023288727C181152851 @default.
• W2023288727 hasConceptScore W2023288727C204232928 @default.
• W2023288727 hasConceptScore W2023288727C207103383 @default.
• W2023288727 hasConceptScore W2023288727C2776530083 @default.
• W2023288727 hasConceptScore W2023288727C2776636583 @default.
• W2023288727 hasConceptScore W2023288727C2776833033 @default.
• W2023288727 hasConceptScore W2023288727C2779013556 @default.
• W2023288727 hasConceptScore W2023288727C2780849966 @default.
• W2023288727 hasConceptScore W2023288727C2780965494 @default.
• W2023288727 hasConceptScore W2023288727C4224716 @default.
• W2023288727 hasConceptScore W2023288727C44249647 @default.
• W2023288727 hasConceptScore W2023288727C71924100 @default.
• W2023288727 hasIssue "2" @default.
• W2023288727 hasLocation W20232887271 @default.
• W2023288727 hasLocation W20232887272 @default.
• W2023288727 hasOpenAccess W2023288727 @default.
• W2023288727 hasPrimaryLocation W20232887271 @default.
• W2023288727 hasRelatedWork W1951940950 @default.
• W2023288727 hasRelatedWork W1995871134 @default.
• W2023288727 hasRelatedWork W1997514069 @default.
• W2023288727 hasRelatedWork W2020958716 @default.
• W2023288727 hasRelatedWork W2060933527 @default.

• next