FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023289733> ?p ?o ?g. }

• W2023289733 endingPage "423" @default.
• W2023289733 startingPage "414" @default.
• W2023289733 abstract "Expression of selenocysteine (Sec)-containing proteins requires the presence of a cis -acting mRNA structure, called selenocysteine insertion sequence (SECIS) element. In bacteria, this structure is located in the coding region immediately downstream of the Sec-encoding UGA codon, whereas in eukaryotes a completely different SECIS element has evolved in the 3′-untranslated region. Here, we report that SECIS elements in the coding regions of selenoprotein mRNAs support Sec insertion in higher eukaryotes. Comprehensive computational analysis of all available viral genomes revealed a SECIS element within the ORF of a naturally occurring selenoprotein homolog of glutathione peroxidase 4 in fowlpox virus. The fowlpox SECIS element supported Sec insertion when expressed in mammalian cells as part of the coding region of viral or mammalian selenoproteins. In addition, readthrough at UGA was observed when the viral SECIS element was located upstream of the Sec codon. We also demonstrate successful de novo design of a functional SECIS element in the coding region of a mammalian selenoprotein. Our data provide evidence that the location of the SECIS element in the untranslated region is not a functional necessity but rather is an evolutionary adaptation to enable a more efficient synthesis of selenoproteins." @default.
• W2023289733 created "2016-06-24" @default.
• W2023289733 creator A5010080171 @default.
• W2023289733 creator A5051485055 @default.
• W2023289733 creator A5071025197 @default.
• W2023289733 date "2006-12-14" @default.
• W2023289733 modified "2023-10-10" @default.
• W2023289733 title "SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes" @default.
• W2023289733 cites W1502260395 @default.
• W2023289733 cites W1878307630 @default.
• W2023289733 cites W1964552840 @default.
• W2023289733 cites W1971402937 @default.
• W2023289733 cites W1977540067 @default.
• W2023289733 cites W1981268894 @default.
• W2023289733 cites W2002209113 @default.
• W2023289733 cites W2015292449 @default.
• W2023289733 cites W2018768462 @default.
• W2023289733 cites W2024177760 @default.
• W2023289733 cites W2027629550 @default.
• W2023289733 cites W2027933081 @default.
• W2023289733 cites W2028171330 @default.
• W2023289733 cites W2033675931 @default.
• W2023289733 cites W2077024527 @default.
• W2023289733 cites W2098890352 @default.
• W2023289733 cites W2100478383 @default.
• W2023289733 cites W2102265972 @default.
• W2023289733 cites W2117310188 @default.
• W2023289733 cites W2125858402 @default.
• W2023289733 cites W2131185306 @default.
• W2023289733 cites W2132658326 @default.
• W2023289733 cites W2133992949 @default.
• W2023289733 cites W2142704205 @default.
• W2023289733 cites W2153312849 @default.
• W2023289733 cites W2165072468 @default.
• W2023289733 cites W2167770444 @default.
• W2023289733 cites W2168221920 @default.
• W2023289733 cites W2168433858 @default.
• W2023289733 cites W2170496993 @default.
• W2023289733 cites W37022542 @default.
• W2023289733 cites W4205640987 @default.
• W2023289733 doi "https://doi.org/10.1093/nar/gkl1060" @default.
• W2023289733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1802603" @default.
• W2023289733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17169995" @default.
• W2023289733 hasPublicationYear "2006" @default.
• W2023289733 type Work @default.
• W2023289733 sameAs 2023289733 @default.
• W2023289733 citedByCount "37" @default.
• W2023289733 countsByYear W20232897332012 @default.
• W2023289733 countsByYear W20232897332013 @default.
• W2023289733 countsByYear W20232897332014 @default.
• W2023289733 countsByYear W20232897332015 @default.
• W2023289733 countsByYear W20232897332016 @default.
• W2023289733 countsByYear W20232897332017 @default.
• W2023289733 countsByYear W20232897332018 @default.
• W2023289733 countsByYear W20232897332019 @default.
• W2023289733 countsByYear W20232897332020 @default.
• W2023289733 countsByYear W20232897332021 @default.
• W2023289733 countsByYear W20232897332023 @default.
• W2023289733 crossrefType "journal-article" @default.
• W2023289733 hasAuthorship W2023289733A5010080171 @default.
• W2023289733 hasAuthorship W2023289733A5051485055 @default.
• W2023289733 hasAuthorship W2023289733A5071025197 @default.
• W2023289733 hasBestOaLocation W20232897331 @default.
• W2023289733 hasConcept C104317684 @default.
• W2023289733 hasConcept C105580179 @default.
• W2023289733 hasConcept C141231307 @default.
• W2023289733 hasConcept C153957851 @default.
• W2023289733 hasConcept C157887575 @default.
• W2023289733 hasConcept C176990463 @default.
• W2023289733 hasConcept C181199279 @default.
• W2023289733 hasConcept C20580545 @default.
• W2023289733 hasConcept C2776087148 @default.
• W2023289733 hasConcept C2776841403 @default.
• W2023289733 hasConcept C2778760513 @default.
• W2023289733 hasConcept C2779201268 @default.
• W2023289733 hasConcept C4918238 @default.
• W2023289733 hasConcept C538909803 @default.
• W2023289733 hasConcept C54355233 @default.
• W2023289733 hasConcept C55493867 @default.
• W2023289733 hasConcept C67705224 @default.
• W2023289733 hasConcept C86803240 @default.
• W2023289733 hasConcept C89604277 @default.
• W2023289733 hasConcept C91779695 @default.
• W2023289733 hasConceptScore W2023289733C104317684 @default.
• W2023289733 hasConceptScore W2023289733C105580179 @default.
• W2023289733 hasConceptScore W2023289733C141231307 @default.
• W2023289733 hasConceptScore W2023289733C153957851 @default.
• W2023289733 hasConceptScore W2023289733C157887575 @default.
• W2023289733 hasConceptScore W2023289733C176990463 @default.
• W2023289733 hasConceptScore W2023289733C181199279 @default.
• W2023289733 hasConceptScore W2023289733C20580545 @default.
• W2023289733 hasConceptScore W2023289733C2776087148 @default.
• W2023289733 hasConceptScore W2023289733C2776841403 @default.
• W2023289733 hasConceptScore W2023289733C2778760513 @default.
• W2023289733 hasConceptScore W2023289733C2779201268 @default.
• W2023289733 hasConceptScore W2023289733C4918238 @default.
• W2023289733 hasConceptScore W2023289733C538909803 @default.
• W2023289733 hasConceptScore W2023289733C54355233 @default.

• next