FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023291476> ?p ?o ?g. }

• W2023291476 endingPage "516" @default.
• W2023291476 startingPage "510" @default.
• W2023291476 abstract "Interferon is the primary treatment for hepatitis C virus (HCV). However, the long-term success rate is low particularly for African Americans relative to Caucasians and may be due to differential immune abilities. This study compared cytokine production from PHA-stimulated peripheral blood from 25 healthy and 40 HCV-infected African Americans and Caucasians. HCV patients were designated as IFN responders or nonresponders based on outcome after therapy. Ethnicity and genotype were associated with IFN response. IFN responders were 100% Caucasian, whereas nonresponders were 67% Caucasian and 33% African American (P = 0.01). Genotype 1 was present in 100% nonresponders and 50% responders (P < 0.05). Age, sex, liver histology, ALT, and viral titers were equivalent (ns). Cytokine production from healthy individuals showed ethnic variation in cytokine levels. Healthy African Americans produced greater amounts of IL-2 (P = 0.06), TNF-alpha (P = 0.06) and less IL-10 (P = 0.05) than healthy Caucasians. In contrast, IFN-gamma and TGF-beta levels were equivalent. Pretherapy cytokine production among HCV patients showed a similar pattern of ethnic variation. African American nonresponders produced more IL-2 (P = 0.06) and TNF-alpha (P = 0.02) than Caucasian nonresponders. Cytokine levels among Caucasian and African American nonresponders were equivalent (P = ns) to ethnically matched healthy individuals whereas Caucasian responders produced subnormal levels of IL-10 (P < 0.05) and TGF-beta (P < 0.05). Since all African Americans failed IFN therapy, cytokine production could not be compared with therapeutic outcome. However, comparison of cytokine production among Caucasians showed that responders produced less IL-10 (P < 0.001) and more TGF-beta (P = 0.06) than nonresponders and predicted Caucasian nonresponders with 83% sensitivity and 96% specificity. HCV genotype was not relevant to cytokine production (P = ns). Distribution of cytokine genetic polymorphisms (TNF-alpha, TNF-beta, IL-10, TGF-beta) was equivalent in all ethnic groups and did not predict clinical nonresponders. In summary, it appears that ethnicity may contribute to variable immune responses and therapeutic outcome. The cytokine profile among African Americans suggests a more robust immune response, which may complicate therapy with IFN. In contrast, the subnormal cytokine production among Caucasian responders may be more permissive to IFN therapy. Pretherapy cytokine production may allow prediction of drug resistance among Caucasians." @default.
• W2023291476 created "2016-06-24" @default.
• W2023291476 creator A5010968373 @default.
• W2023291476 creator A5031268451 @default.
• W2023291476 creator A5074819836 @default.
• W2023291476 date "2001-10-08" @default.
• W2023291476 modified "2023-10-09" @default.
• W2023291476 title "Ethnicity and cytokine production gauge response of patients with hepatitis C to interferon-? therapy" @default.
• W2023291476 cites W1976110218 @default.
• W2023291476 cites W1985433337 @default.
• W2023291476 cites W1994529038 @default.
• W2023291476 cites W1999925921 @default.
• W2023291476 cites W2002120703 @default.
• W2023291476 cites W2005863439 @default.
• W2023291476 cites W2013464905 @default.
• W2023291476 cites W2018772554 @default.
• W2023291476 cites W2018964760 @default.
• W2023291476 cites W2025561889 @default.
• W2023291476 cites W2037812765 @default.
• W2023291476 cites W2042459994 @default.
• W2023291476 cites W2046954035 @default.
• W2023291476 cites W2049494801 @default.
• W2023291476 cites W2050776853 @default.
• W2023291476 cites W2054360023 @default.
• W2023291476 cites W2059636482 @default.
• W2023291476 cites W2059833361 @default.
• W2023291476 cites W2067309227 @default.
• W2023291476 cites W2067435274 @default.
• W2023291476 cites W2087994218 @default.
• W2023291476 cites W2088516527 @default.
• W2023291476 cites W2099680414 @default.
• W2023291476 cites W2126008417 @default.
• W2023291476 cites W2129767605 @default.
• W2023291476 cites W2132132955 @default.
• W2023291476 cites W2135715865 @default.
• W2023291476 cites W2141618432 @default.
• W2023291476 cites W2147717433 @default.
• W2023291476 cites W2156326428 @default.
• W2023291476 cites W2161546631 @default.
• W2023291476 cites W2165715544 @default.
• W2023291476 cites W2170200856 @default.
• W2023291476 cites W2317554121 @default.
• W2023291476 cites W2336799715 @default.
• W2023291476 cites W2509204406 @default.
• W2023291476 cites W3137628270 @default.
• W2023291476 doi "https://doi.org/10.1002/jmv.2065" @default.
• W2023291476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11596086" @default.
• W2023291476 hasPublicationYear "2001" @default.
• W2023291476 type Work @default.
• W2023291476 sameAs 2023291476 @default.
• W2023291476 citedByCount "73" @default.
• W2023291476 countsByYear W20232914762012 @default.
• W2023291476 countsByYear W20232914762013 @default.
• W2023291476 countsByYear W20232914762014 @default.
• W2023291476 countsByYear W20232914762015 @default.
• W2023291476 countsByYear W20232914762017 @default.
• W2023291476 countsByYear W20232914762019 @default.
• W2023291476 crossrefType "journal-article" @default.
• W2023291476 hasAuthorship W2023291476A5010968373 @default.
• W2023291476 hasAuthorship W2023291476A5031268451 @default.
• W2023291476 hasAuthorship W2023291476A5074819836 @default.
• W2023291476 hasConcept C104317684 @default.
• W2023291476 hasConcept C126322002 @default.
• W2023291476 hasConcept C135763542 @default.
• W2023291476 hasConcept C203014093 @default.
• W2023291476 hasConcept C2522874641 @default.
• W2023291476 hasConcept C2776178377 @default.
• W2023291476 hasConcept C2776408679 @default.
• W2023291476 hasConcept C2776455275 @default.
• W2023291476 hasConcept C2778690821 @default.
• W2023291476 hasConcept C55493867 @default.
• W2023291476 hasConcept C71924100 @default.
• W2023291476 hasConcept C86803240 @default.
• W2023291476 hasConcept C90924648 @default.
• W2023291476 hasConceptScore W2023291476C104317684 @default.
• W2023291476 hasConceptScore W2023291476C126322002 @default.
• W2023291476 hasConceptScore W2023291476C135763542 @default.
• W2023291476 hasConceptScore W2023291476C203014093 @default.
• W2023291476 hasConceptScore W2023291476C2522874641 @default.
• W2023291476 hasConceptScore W2023291476C2776178377 @default.
• W2023291476 hasConceptScore W2023291476C2776408679 @default.
• W2023291476 hasConceptScore W2023291476C2776455275 @default.
• W2023291476 hasConceptScore W2023291476C2778690821 @default.
• W2023291476 hasConceptScore W2023291476C55493867 @default.
• W2023291476 hasConceptScore W2023291476C71924100 @default.
• W2023291476 hasConceptScore W2023291476C86803240 @default.
• W2023291476 hasConceptScore W2023291476C90924648 @default.
• W2023291476 hasIssue "3" @default.
• W2023291476 hasLocation W20232914761 @default.
• W2023291476 hasLocation W20232914762 @default.
• W2023291476 hasOpenAccess W2023291476 @default.
• W2023291476 hasPrimaryLocation W20232914761 @default.
• W2023291476 hasRelatedWork W2052290779 @default.
• W2023291476 hasRelatedWork W2107508210 @default.
• W2023291476 hasRelatedWork W2110395692 @default.
• W2023291476 hasRelatedWork W2117027295 @default.
• W2023291476 hasRelatedWork W2130839534 @default.
• W2023291476 hasRelatedWork W2418235480 @default.

• next