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• W2023292223 startingPage "769" @default.
• W2023292223 abstract "Chromosome replication initiates without sequence specificity at average intervals of approximately 10 kb during the rapid cell cycles of early Xenopus embryos. If the distribution of origins were random, some inter-origin intervals would be too long to be fully replicated before the end of S phase. To investigate what ensures rapid completion of DNA replication, we have examined the replication intermediates of plasmids of various sizes (5.3-42.2 kbp) in Xenopus egg extracts by two-dimensional gel electrophoresis and electron microscopy. We confirm that replication initiates without sequence specificity on all plasmids. We demonstrate for the first time that multiple initiation events occur on large plasmids, but not on small (<10 kb) plasmids, at average intervals of approximately 10 kb. Origin interference may prevent multiple initiation events on small plasmids. Multiple initiation events are neither synchronous nor regularly spaced. Bubble density is higher on later than on earlier replication intermediates, showing that initiation frequency increases throughout S phase, speeding up replication of late intermediates. We suggest that potential origins are abundant and randomly distributed, but that the increase of initiation frequency during S phase, and possibly origin interference, regulate origin activation to ensure rapid completion of replication." @default.
• W2023292223 created "2016-06-24" @default.
• W2023292223 creator A5001373766 @default.
• W2023292223 creator A5007655086 @default.
• W2023292223 creator A5038794106 @default.
• W2023292223 creator A5047558848 @default.
• W2023292223 date "2000-02-01" @default.
• W2023292223 modified "2023-10-14" @default.
• W2023292223 title "Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos" @default.
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• W2023292223 doi "https://doi.org/10.1006/jmbi.2000.3500" @default.
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