Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023295368> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2023295368 endingPage "982" @default.
- W2023295368 startingPage "976" @default.
- W2023295368 abstract "Ten patients with refractory rheumatoid arthritis were given 3000 rad of fractionated total lymphoid irradiation in an uncontrolled therapeutic trial. Total lymphoid irradiation was associated with objective evidence of considerable clinical improvement in eight patients and with reduced blood lymphocyte counts in all 10. On completion of irradiation, there was an abrogation of lymphocyte reactivity in vitro in the patients with clinical responses, but abnormal antibody activities characteristic of rheumatoid arthritis and normal components of humoral immunity were not suppressed. Partial recrudescence of arthritis occurred shortly before a year after the completion of irradiation and was paralleled by a restitution of lymphocyte concentrations and responsiveness to mitogens to levels similar to those observed before irradiation. These data provide further evidence of T-cell involvement in the pathogenesis of rheumatoid arthritis and demonstrate that total lymphoid irradiation can induce temporary relief, but they do not ascertain whether the natural history of this disease was altered. (N Engl J Med. 1981; 305:976–82.)" @default.
- W2023295368 created "2016-06-24" @default.
- W2023295368 creator A5001558679 @default.
- W2023295368 creator A5039862405 @default.
- W2023295368 creator A5052600802 @default.
- W2023295368 creator A5068192991 @default.
- W2023295368 creator A5068612343 @default.
- W2023295368 creator A5075337981 @default.
- W2023295368 creator A5077439065 @default.
- W2023295368 date "1981-10-22" @default.
- W2023295368 modified "2023-10-18" @default.
- W2023295368 title "Clinical and Immunologic Effects of Fractionated Total Lymphoid Irradiation in Refractory Rheumatoid Arthritis" @default.
- W2023295368 cites W1502504154 @default.
- W2023295368 cites W1565321369 @default.
- W2023295368 cites W1571615542 @default.
- W2023295368 cites W1909642617 @default.
- W2023295368 cites W1968374691 @default.
- W2023295368 cites W1972314619 @default.
- W2023295368 cites W1984843177 @default.
- W2023295368 cites W1996319031 @default.
- W2023295368 cites W2013120413 @default.
- W2023295368 cites W2014372881 @default.
- W2023295368 cites W2039106940 @default.
- W2023295368 cites W2046741533 @default.
- W2023295368 cites W2049021766 @default.
- W2023295368 cites W2085128973 @default.
- W2023295368 cites W2097370909 @default.
- W2023295368 cites W2125469152 @default.
- W2023295368 cites W2128965382 @default.
- W2023295368 cites W2150088335 @default.
- W2023295368 cites W2151246967 @default.
- W2023295368 cites W2156895470 @default.
- W2023295368 cites W2166629922 @default.
- W2023295368 cites W2296952553 @default.
- W2023295368 cites W2337151074 @default.
- W2023295368 cites W2339159304 @default.
- W2023295368 cites W3156183671 @default.
- W2023295368 cites W4230411078 @default.
- W2023295368 doi "https://doi.org/10.1056/nejm198110223051703" @default.
- W2023295368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7024811" @default.
- W2023295368 hasPublicationYear "1981" @default.
- W2023295368 type Work @default.
- W2023295368 sameAs 2023295368 @default.
- W2023295368 citedByCount "159" @default.
- W2023295368 crossrefType "journal-article" @default.
- W2023295368 hasAuthorship W2023295368A5001558679 @default.
- W2023295368 hasAuthorship W2023295368A5039862405 @default.
- W2023295368 hasAuthorship W2023295368A5052600802 @default.
- W2023295368 hasAuthorship W2023295368A5068192991 @default.
- W2023295368 hasAuthorship W2023295368A5068612343 @default.
- W2023295368 hasAuthorship W2023295368A5075337981 @default.
- W2023295368 hasAuthorship W2023295368A5077439065 @default.
- W2023295368 hasConcept C126322002 @default.
- W2023295368 hasConcept C142424586 @default.
- W2023295368 hasConcept C181152851 @default.
- W2023295368 hasConcept C203014093 @default.
- W2023295368 hasConcept C2777077863 @default.
- W2023295368 hasConcept C2777575956 @default.
- W2023295368 hasConcept C2777761686 @default.
- W2023295368 hasConcept C2780942790 @default.
- W2023295368 hasConcept C71924100 @default.
- W2023295368 hasConcept C86803240 @default.
- W2023295368 hasConcept C87355193 @default.
- W2023295368 hasConceptScore W2023295368C126322002 @default.
- W2023295368 hasConceptScore W2023295368C142424586 @default.
- W2023295368 hasConceptScore W2023295368C181152851 @default.
- W2023295368 hasConceptScore W2023295368C203014093 @default.
- W2023295368 hasConceptScore W2023295368C2777077863 @default.
- W2023295368 hasConceptScore W2023295368C2777575956 @default.
- W2023295368 hasConceptScore W2023295368C2777761686 @default.
- W2023295368 hasConceptScore W2023295368C2780942790 @default.
- W2023295368 hasConceptScore W2023295368C71924100 @default.
- W2023295368 hasConceptScore W2023295368C86803240 @default.
- W2023295368 hasConceptScore W2023295368C87355193 @default.
- W2023295368 hasIssue "17" @default.
- W2023295368 hasLocation W20232953681 @default.
- W2023295368 hasLocation W20232953682 @default.
- W2023295368 hasOpenAccess W2023295368 @default.
- W2023295368 hasPrimaryLocation W20232953681 @default.
- W2023295368 hasRelatedWork W1963511249 @default.
- W2023295368 hasRelatedWork W2077699888 @default.
- W2023295368 hasRelatedWork W2156283049 @default.
- W2023295368 hasRelatedWork W2316954211 @default.
- W2023295368 hasRelatedWork W2351796763 @default.
- W2023295368 hasRelatedWork W2427075784 @default.
- W2023295368 hasRelatedWork W2761967325 @default.
- W2023295368 hasRelatedWork W3030951269 @default.
- W2023295368 hasRelatedWork W3194400168 @default.
- W2023295368 hasRelatedWork W71700122 @default.
- W2023295368 hasVolume "305" @default.
- W2023295368 isParatext "false" @default.
- W2023295368 isRetracted "false" @default.
- W2023295368 magId "2023295368" @default.
- W2023295368 workType "article" @default.