FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023295457> ?p ?o ?g. }

• W2023295457 endingPage "2091" @default.
• W2023295457 startingPage "2090" @default.
• W2023295457 abstract "The recent article by Frankenberg et al. about how the membrane protein adenosine triphosphatase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor (FXR) was highly though-provoking and fascinating.1 The authors have clearly illustrated the important role of FXRs in human physiology and pathology. Modulation of FXR function has been in focus recently, and an interesting new antagonist (guggulsterone) has been identified in this regards. The potential role of guggulsterone in clinical medicine has been highlighted by recent studies that have demonstrated its beneficial effects in diseases ranging from systemic malignancies to morbid obesity. For instance, guggulsterone has an antiproliferative effect not just on dermatologic malignancies2 such as malignant melanomas but also on a myriad number of other localized malignancies such as breast carcinomas as well as a number of systemic hematological malignancies such as leukemias.3 These antiproliferative effects are in part due to the inhibition of tumor angiogenesis.4 Guggulsterone also effectively and remarkably induces apoptosis in cell lines derived from Barrett's esophagitis. In fact, guggulsterone attenuates the expression of the FXR secondary to stimulation by bile acids in subjects with Barrett's esophagitis.5 Barrett's esophagitis is a precursor of esophageal adenocarcinoma and this inhibitory effect may have a major role to play in the near future in cancer chemoprevention in patients with Barrett's esophagitis.6 Guggulsterone performs these functions by the suppression of nuclear factor-kappa B activation as well as signal transducer and activator of transcription 3 (STAT3) activation7 in tissues ranging from myeloma cells to pancreatic tissue.8 Besides anticarcinogenic properties, guggulsterone also has highly beneficial cardiovascular effects as a result of its anti-inflammatory and hypolipidemic properties9 and also prevents cytokine-mediated cytotoxicity in pancreatic beta cells.8 Guggulsterone also inhibits differentiation of adipocytes and may thus have a potential role in weight loss.10 Similarly, Lee et al. have recently shown that guggulsterone also blocks interleukin-1beta–mediated inflammatory responses in synoviocytes.11 The data from all these studies support the rapidly expanding evidence in support of the anti-inflammatory properties of guggulsterone. Clearly, guggulsterone may very well prove to be a major tool in the hands of physicians and oncologists in the fight against various systemic cancers as well as diseases such as obesity in the near future. Shailendra Kapoor*, * Chicago, IL." @default.
• W2023295457 created "2016-06-24" @default.
• W2023295457 creator A5068544138 @default.
• W2023295457 date "2008-10-09" @default.
• W2023295457 modified "2023-09-25" @default.
• W2023295457 title "Guggulsterone: A potent farnesoid X receptor antagonist and its rapidly evolving role as a systemic anticarcinogenic agent" @default.
• W2023295457 cites W1923030440 @default.
• W2023295457 cites W2026159920 @default.
• W2023295457 cites W2039630136 @default.
• W2023295457 cites W2047757285 @default.
• W2023295457 cites W2071890726 @default.
• W2023295457 cites W2072701088 @default.
• W2023295457 cites W2076468574 @default.
• W2023295457 cites W2098979399 @default.
• W2023295457 cites W2134329158 @default.
• W2023295457 cites W2153454029 @default.
• W2023295457 doi "https://doi.org/10.1002/hep.22601" @default.
• W2023295457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18980177" @default.
• W2023295457 hasPublicationYear "2008" @default.
• W2023295457 type Work @default.
• W2023295457 sameAs 2023295457 @default.
• W2023295457 citedByCount "5" @default.
• W2023295457 countsByYear W20232954572012 @default.
• W2023295457 countsByYear W20232954572013 @default.
• W2023295457 countsByYear W20232954572017 @default.
• W2023295457 countsByYear W20232954572020 @default.
• W2023295457 crossrefType "journal-article" @default.
• W2023295457 hasAuthorship W2023295457A5068544138 @default.
• W2023295457 hasBestOaLocation W20232954571 @default.
• W2023295457 hasConcept C104317684 @default.
• W2023295457 hasConcept C126322002 @default.
• W2023295457 hasConcept C171958077 @default.
• W2023295457 hasConcept C203862802 @default.
• W2023295457 hasConcept C2778923194 @default.
• W2023295457 hasConcept C502942594 @default.
• W2023295457 hasConcept C55493867 @default.
• W2023295457 hasConcept C62478195 @default.
• W2023295457 hasConcept C63932345 @default.
• W2023295457 hasConcept C71924100 @default.
• W2023295457 hasConcept C86339819 @default.
• W2023295457 hasConcept C86803240 @default.
• W2023295457 hasConcept C95444343 @default.
• W2023295457 hasConcept C98274493 @default.
• W2023295457 hasConceptScore W2023295457C104317684 @default.
• W2023295457 hasConceptScore W2023295457C126322002 @default.
• W2023295457 hasConceptScore W2023295457C171958077 @default.
• W2023295457 hasConceptScore W2023295457C203862802 @default.
• W2023295457 hasConceptScore W2023295457C2778923194 @default.
• W2023295457 hasConceptScore W2023295457C502942594 @default.
• W2023295457 hasConceptScore W2023295457C55493867 @default.
• W2023295457 hasConceptScore W2023295457C62478195 @default.
• W2023295457 hasConceptScore W2023295457C63932345 @default.
• W2023295457 hasConceptScore W2023295457C71924100 @default.
• W2023295457 hasConceptScore W2023295457C86339819 @default.
• W2023295457 hasConceptScore W2023295457C86803240 @default.
• W2023295457 hasConceptScore W2023295457C95444343 @default.
• W2023295457 hasConceptScore W2023295457C98274493 @default.
• W2023295457 hasIssue "6" @default.
• W2023295457 hasLocation W20232954571 @default.
• W2023295457 hasLocation W20232954572 @default.
• W2023295457 hasOpenAccess W2023295457 @default.
• W2023295457 hasPrimaryLocation W20232954571 @default.
• W2023295457 hasRelatedWork W1985296107 @default.
• W2023295457 hasRelatedWork W2082184791 @default.
• W2023295457 hasRelatedWork W2111160264 @default.
• W2023295457 hasRelatedWork W2113111181 @default.
• W2023295457 hasRelatedWork W2517208964 @default.
• W2023295457 hasRelatedWork W2602544069 @default.
• W2023295457 hasRelatedWork W2956138079 @default.
• W2023295457 hasRelatedWork W3128743297 @default.
• W2023295457 hasRelatedWork W4225374904 @default.
• W2023295457 hasRelatedWork W4225397885 @default.
• W2023295457 hasVolume "48" @default.
• W2023295457 isParatext "false" @default.
• W2023295457 isRetracted "false" @default.
• W2023295457 magId "2023295457" @default.
• W2023295457 workType "article" @default.