Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023296155> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2023296155 abstract "Abstract Oxazolidine ring-opening and ring-closing (acid-base equilibrium) reactions of 3-methyl-11 b -hydrogen ( 1 ) and −11 b -methyl ( 2 ) analogues of mexazolam ( 3 ) have been studied kinetically in solutions of various pH values and at 25°C. Compound 2 isomerizes to the cis/trans isomers (referring to substituents at the 3- and 11 b -position) in methanol-d 4 withh a half-life of baout 50 min, and at equilibrium the ratio of the cis to trans isomers is 6.9:1. The acid-base equilibrium reactions of 1 and 2 proceed via two steps due to the cis and trans isomers, the reactions of the trans isomer being faster than those of the cis isomer. The large difference between the cis and trans isomers of 2 is ascribed to their conformational differences (normal boat X 1 and flat form Y 11 , respectively). These results required a modification of the mechanism previously proposed for mexazolam (Kurono et al., Chem. Pharm. Bull. , 35 (1987) 3831–3837)." @default.
- W2023296155 created "2016-06-24" @default.
- W2023296155 creator A5007017957 @default.
- W2023296155 creator A5019253195 @default.
- W2023296155 creator A5020853632 @default.
- W2023296155 creator A5024745304 @default.
- W2023296155 creator A5051748464 @default.
- W2023296155 creator A5071833902 @default.
- W2023296155 creator A5074207384 @default.
- W2023296155 creator A5080803670 @default.
- W2023296155 date "1992-02-01" @default.
- W2023296155 modified "2023-09-23" @default.
- W2023296155 title "Kinetics and mechanism of the acid-base equilibrium of mexazolam analogues: A modification of the mechanism proposed previously for mexazolam" @default.
- W2023296155 cites W1720542329 @default.
- W2023296155 cites W1976008991 @default.
- W2023296155 cites W2008149970 @default.
- W2023296155 cites W2065896908 @default.
- W2023296155 cites W2081037336 @default.
- W2023296155 cites W2092345294 @default.
- W2023296155 cites W2312990554 @default.
- W2023296155 cites W2318145056 @default.
- W2023296155 cites W2321673192 @default.
- W2023296155 cites W2325489987 @default.
- W2023296155 cites W2334687807 @default.
- W2023296155 cites W2417253523 @default.
- W2023296155 cites W2605645041 @default.
- W2023296155 cites W2605761599 @default.
- W2023296155 cites W324317825 @default.
- W2023296155 doi "https://doi.org/10.1016/0378-5173(92)90271-3" @default.
- W2023296155 hasPublicationYear "1992" @default.
- W2023296155 type Work @default.
- W2023296155 sameAs 2023296155 @default.
- W2023296155 citedByCount "1" @default.
- W2023296155 crossrefType "journal-article" @default.
- W2023296155 hasAuthorship W2023296155A5007017957 @default.
- W2023296155 hasAuthorship W2023296155A5019253195 @default.
- W2023296155 hasAuthorship W2023296155A5020853632 @default.
- W2023296155 hasAuthorship W2023296155A5024745304 @default.
- W2023296155 hasAuthorship W2023296155A5051748464 @default.
- W2023296155 hasAuthorship W2023296155A5071833902 @default.
- W2023296155 hasAuthorship W2023296155A5074207384 @default.
- W2023296155 hasAuthorship W2023296155A5080803670 @default.
- W2023296155 hasConcept C121332964 @default.
- W2023296155 hasConcept C134306372 @default.
- W2023296155 hasConcept C148898269 @default.
- W2023296155 hasConcept C161790260 @default.
- W2023296155 hasConcept C176788430 @default.
- W2023296155 hasConcept C178790620 @default.
- W2023296155 hasConcept C185592680 @default.
- W2023296155 hasConcept C2779607525 @default.
- W2023296155 hasConcept C2780378348 @default.
- W2023296155 hasConcept C33923547 @default.
- W2023296155 hasConcept C42058472 @default.
- W2023296155 hasConcept C62520636 @default.
- W2023296155 hasConcept C65024703 @default.
- W2023296155 hasConcept C71240020 @default.
- W2023296155 hasConceptScore W2023296155C121332964 @default.
- W2023296155 hasConceptScore W2023296155C134306372 @default.
- W2023296155 hasConceptScore W2023296155C148898269 @default.
- W2023296155 hasConceptScore W2023296155C161790260 @default.
- W2023296155 hasConceptScore W2023296155C176788430 @default.
- W2023296155 hasConceptScore W2023296155C178790620 @default.
- W2023296155 hasConceptScore W2023296155C185592680 @default.
- W2023296155 hasConceptScore W2023296155C2779607525 @default.
- W2023296155 hasConceptScore W2023296155C2780378348 @default.
- W2023296155 hasConceptScore W2023296155C33923547 @default.
- W2023296155 hasConceptScore W2023296155C42058472 @default.
- W2023296155 hasConceptScore W2023296155C62520636 @default.
- W2023296155 hasConceptScore W2023296155C65024703 @default.
- W2023296155 hasConceptScore W2023296155C71240020 @default.
- W2023296155 hasLocation W20232961551 @default.
- W2023296155 hasOpenAccess W2023296155 @default.
- W2023296155 hasPrimaryLocation W20232961551 @default.
- W2023296155 hasRelatedWork W1587815586 @default.
- W2023296155 hasRelatedWork W1981570674 @default.
- W2023296155 hasRelatedWork W1984017141 @default.
- W2023296155 hasRelatedWork W1984210107 @default.
- W2023296155 hasRelatedWork W1995228119 @default.
- W2023296155 hasRelatedWork W2021488371 @default.
- W2023296155 hasRelatedWork W2032069168 @default.
- W2023296155 hasRelatedWork W2035301916 @default.
- W2023296155 hasRelatedWork W2035394944 @default.
- W2023296155 hasRelatedWork W2037344831 @default.
- W2023296155 hasRelatedWork W2055672780 @default.
- W2023296155 hasRelatedWork W2071357455 @default.
- W2023296155 hasRelatedWork W2071778848 @default.
- W2023296155 hasRelatedWork W2093788828 @default.
- W2023296155 hasRelatedWork W2104119131 @default.
- W2023296155 hasRelatedWork W2146769044 @default.
- W2023296155 hasRelatedWork W2738866294 @default.
- W2023296155 hasRelatedWork W2950800157 @default.
- W2023296155 hasRelatedWork W2951261036 @default.
- W2023296155 hasRelatedWork W2953079471 @default.
- W2023296155 isParatext "false" @default.
- W2023296155 isRetracted "false" @default.
- W2023296155 magId "2023296155" @default.
- W2023296155 workType "article" @default.