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• W2023298703 abstract "MCF-7 breast tumor cells form multicellular nodules (foci) over a confluent monolayer in an estradiol (E2)-dependent, antiestrogen-sensitive reaction. A cell line cloned from MCF-7 that displays these phenotypes was probed to determine the effects of long term exposure to tamoxifen on the growth of foci, estrogen receptor alpha (ERα) status, and gene responsiveness to E2. In one of two experiments, a heterogeneous cell population emerged (TMX2) that over-expressed estrogen receptor alpha wild type mRNA (ERα mRNA) (∼20-fold) missing exon 3 (ERΔ3 mRNA) and its corresponding protein (ERΔ3P). On a per mRNA to protein basis, ERΔ3P and wild-type ERα were equivalently expressed. Return of the TMX2 population to medium without tamoxifen eventually selected for a population that expressed predominately wild-type ERα, whereas TMX2 clones over expressing ERΔ3 mRNA and ERΔ3P retained this phenotype in tamoxifen-free media. In both experiments, expression of all ERα mRNAs and proteins declined to barely detectable levels during 6–12 months exposure, concomitant with a progressive increase in the ability of the cells to form foci independently of E2 or tamoxifen. Selection for these various populations suggests that tamoxifen can induce and/or support certain cellular changes that lead to altered ERα expression, E2-independent cell growth and resistance to antiestrogens." @default.
• W2023298703 created "2016-06-24" @default.
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• W2023298703 date "2003-08-01" @default.
• W2023298703 modified "2023-10-10" @default.
• W2023298703 title "Phenotypic changes in MCF-7 cells during prolonged exposure to tamoxifen" @default.
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• W2023298703 doi "https://doi.org/10.1016/s0303-7207(03)00256-9" @default.
• W2023298703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12943988" @default.
• W2023298703 hasPublicationYear "2003" @default.
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