FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023300047> ?p ?o ?g. }

• W2023300047 endingPage "1217" @default.
• W2023300047 startingPage "1211" @default.
• W2023300047 abstract "The human decidua contains an unusually high proportion of lymphocytes, mainly NK and T cells, which are potentially cytotoxic to the trophoblast when they are stimulated with certain cytokines. Given the high incidence of spontaneous abortion in humans and other species, our working hypothesis is that decidual lymphocytes are involved in immunological mechanisms that attack the trophoblast and induce abortion when any gestational problem arises. To test this hypothesis, flow cytometry was used to compare decidual lymphocyte populations in first-trimester spontaneous abortions and elective terminations of first-trimester pregnancy. We found significantly higher proportions of decidual lymphocytes that expressed activation markers, and of T cells (mainly T helper cells) in spontaneous abortions than in elective terminations of pregnancy. Decidual lymphocytes from spontaneous abortion, like decidual lymphocytes from elective termination of pregnancy and peripheral blood lymphocytes, were however, unable to lyse the JEG-3 extravillous cytotrophoblast cell line in a (51)Cr-release assay. Nevertheless, decidual lymphocytes from spontaneous abortion, unlike decidual lymphocytes from elective termination of pregnancy and peripheral blood lymphocytes, induced apoptosis in JEG-3 cells as determined by DNA fragment-release assay. Hematoxylin and eosin staining showed a significantly higher proportion of apoptotic JEG-3 cells when these cells were treated with decidual lymphocytes from spontaneous abortion than when JEG-3 cells were cultured with decidual lymphocytes from elective termination of pregnancy. The ultrastructural signs of apoptosis were confirmed by electron microscopy. These data support the hypothesis that activated decidual lymphocytes participate in human spontaneous abortion by inducing apoptosis but not necrosis of the trophoblast." @default.
• W2023300047 created "2016-06-24" @default.
• W2023300047 creator A5010868256 @default.
• W2023300047 creator A5044249036 @default.
• W2023300047 creator A5046765453 @default.
• W2023300047 creator A5049428033 @default.
• W2023300047 creator A5060705941 @default.
• W2023300047 creator A5087732828 @default.
• W2023300047 date "2002-10-01" @default.
• W2023300047 modified "2023-10-12" @default.
• W2023300047 title "Decidual Lymphocytes of Human Spontaneous Abortions Induce Apoptosis but Not Necrosis in JEG-3 Extravillous Trophoblast Cells1" @default.
• W2023300047 cites W1965576556 @default.
• W2023300047 cites W1991605327 @default.
• W2023300047 cites W2004447942 @default.
• W2023300047 cites W2005992769 @default.
• W2023300047 cites W2015260577 @default.
• W2023300047 cites W2019547929 @default.
• W2023300047 cites W2041001602 @default.
• W2023300047 cites W2044530939 @default.
• W2023300047 cites W2047424019 @default.
• W2023300047 cites W2063134190 @default.
• W2023300047 cites W2064353580 @default.
• W2023300047 cites W2067885045 @default.
• W2023300047 cites W2070762401 @default.
• W2023300047 cites W2085583663 @default.
• W2023300047 cites W2092625116 @default.
• W2023300047 cites W2113047400 @default.
• W2023300047 cites W2130443831 @default.
• W2023300047 cites W2130627781 @default.
• W2023300047 cites W2141258097 @default.
• W2023300047 cites W2147567866 @default.
• W2023300047 cites W2162857316 @default.
• W2023300047 cites W2322561651 @default.
• W2023300047 doi "https://doi.org/10.1095/biolreprod67.4.1211" @default.
• W2023300047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12297538" @default.
• W2023300047 hasPublicationYear "2002" @default.
• W2023300047 type Work @default.
• W2023300047 sameAs 2023300047 @default.
• W2023300047 citedByCount "38" @default.
• W2023300047 countsByYear W20233000472012 @default.
• W2023300047 countsByYear W20233000472013 @default.
• W2023300047 countsByYear W20233000472014 @default.
• W2023300047 countsByYear W20233000472015 @default.
• W2023300047 countsByYear W20233000472016 @default.
• W2023300047 countsByYear W20233000472017 @default.
• W2023300047 countsByYear W20233000472019 @default.
• W2023300047 countsByYear W20233000472020 @default.
• W2023300047 crossrefType "journal-article" @default.
• W2023300047 hasAuthorship W2023300047A5010868256 @default.
• W2023300047 hasAuthorship W2023300047A5044249036 @default.
• W2023300047 hasAuthorship W2023300047A5046765453 @default.
• W2023300047 hasAuthorship W2023300047A5049428033 @default.
• W2023300047 hasAuthorship W2023300047A5060705941 @default.
• W2023300047 hasAuthorship W2023300047A5087732828 @default.
• W2023300047 hasBestOaLocation W20233000471 @default.
• W2023300047 hasConcept C134018914 @default.
• W2023300047 hasConcept C16685009 @default.
• W2023300047 hasConcept C172680121 @default.
• W2023300047 hasConcept C190283241 @default.
• W2023300047 hasConcept C203014093 @default.
• W2023300047 hasConcept C2776953305 @default.
• W2023300047 hasConcept C2777495146 @default.
• W2023300047 hasConcept C2777605040 @default.
• W2023300047 hasConcept C2777761686 @default.
• W2023300047 hasConcept C2779234561 @default.
• W2023300047 hasConcept C2780197806 @default.
• W2023300047 hasConcept C2781107390 @default.
• W2023300047 hasConcept C54355233 @default.
• W2023300047 hasConcept C71924100 @default.
• W2023300047 hasConcept C86803240 @default.
• W2023300047 hasConceptScore W2023300047C134018914 @default.
• W2023300047 hasConceptScore W2023300047C16685009 @default.
• W2023300047 hasConceptScore W2023300047C172680121 @default.
• W2023300047 hasConceptScore W2023300047C190283241 @default.
• W2023300047 hasConceptScore W2023300047C203014093 @default.
• W2023300047 hasConceptScore W2023300047C2776953305 @default.
• W2023300047 hasConceptScore W2023300047C2777495146 @default.
• W2023300047 hasConceptScore W2023300047C2777605040 @default.
• W2023300047 hasConceptScore W2023300047C2777761686 @default.
• W2023300047 hasConceptScore W2023300047C2779234561 @default.
• W2023300047 hasConceptScore W2023300047C2780197806 @default.
• W2023300047 hasConceptScore W2023300047C2781107390 @default.
• W2023300047 hasConceptScore W2023300047C54355233 @default.
• W2023300047 hasConceptScore W2023300047C71924100 @default.
• W2023300047 hasConceptScore W2023300047C86803240 @default.
• W2023300047 hasIssue "4" @default.
• W2023300047 hasLocation W20233000471 @default.
• W2023300047 hasLocation W20233000472 @default.
• W2023300047 hasOpenAccess W2023300047 @default.
• W2023300047 hasPrimaryLocation W20233000471 @default.
• W2023300047 hasRelatedWork W1254348016 @default.
• W2023300047 hasRelatedWork W1967832266 @default.
• W2023300047 hasRelatedWork W1976490186 @default.
• W2023300047 hasRelatedWork W2048856649 @default.
• W2023300047 hasRelatedWork W2079832190 @default.
• W2023300047 hasRelatedWork W2319330681 @default.
• W2023300047 hasRelatedWork W2419584773 @default.
• W2023300047 hasRelatedWork W2598267120 @default.

• next