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- W2023301742 abstract "Tissue iron can promote oxidative damage. Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders including Alzheimer's disease (AD) and Parkinson's disease (PD). Higher iron levels in males may contribute to higher risk for younger-onset PD and recent studies have linked the presence of the hemochromatosis gene with a younger age at onset of AD. Examined whether age at onset of AD is associated with increased brain ferritin iron. Ferritin iron can be measured with specificity in vivo with MRI utilizing the Field Dependent Relaxation Rate Increase (FDRI) method. FDRI was assessed in three basal ganglia regions (caudate, putamen, and globus pallidus), three white matter regions (frontal, genu and splenium of corpus callosum), and hippocampus for younger- and older-onset male AD patients and healthy controls. Significant increases in basal ganglia and hippocamap FDRI levels were observed in the younger-onset group compared to the control groups but were absent in the older-onset patients. The results support the suggestion that elevated ferritin iron and its associated toxicity is a risk-factor for age at onset of neurodegenerative diseases such as AD and PD. Clinical phenomena such as gender-associated risk of developing neurodegenerative diseases and the age at onset of such diseases may be associated with brain iron levels. In vivo MRI can measure and track brain ferritin iron levels and provides an opportunity to design therapeutic interventions that target high-risk populations early in the course of illness, possibly even before symptoms appear." @default.
- W2023301742 created "2016-06-24" @default.
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- W2023301742 date "2005-07-01" @default.
- W2023301742 modified "2023-09-27" @default.
- W2023301742 title "Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases" @default.
- W2023301742 doi "https://doi.org/10.1016/j.jalz.2005.06.131" @default.
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