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- W2023301949 abstract "✓ Somatosensory evoked potentials (SEP's) reflect the integrity of the central neuronal pathway, and as such may be used to assess function that remains during a variety of cerebral insults. To evaluate the natural history and utility of SEP's during experimental cerebral ischemia and infarction, SEP's were measured in 17 adult cats at 24 hours and 1 hour prior to right middle cerebral artery (MCA) occlusion, and again immediately afterward and at either 6 hours (five cats) or 24 hours (six cats) post-occlusion. Before occlusion of the right MCA, the SEP's were identical in the right and left hemispheres. After occlusion, there was a significant slowing of the interpeak latency of the first positive peak (P 1 ) in the right hemisphere (3.53 ± 0.6 msec before compared to 3.99 ± 0.6 msec after occlusion, p < 0.001). Maximal slowing in right hemisphere P 1 latency was seen in those animals in which the stroke extended into the thalamus (4.38 ± 0.1 msec). This was significantly slower than left hemisphere values (3.92 ± 0.32 msec, p < 0.01). The ipsilateral cortical components of the SEP's, the second positive peak (P 2 ), and the major negative deflection (MN) were slowed in all cats immediately after right MCA occlusion compared to preocclusion measurements (p < 0.001). Severe infarcts in the mid-suprasylvian and posterior ectosylvian gyri (including the somatosensory cortex) resulted in a greater slowing of the latency of MN compared to less severe infarcts in that region (20.6 ± 3.9 msec versus 16.4 ± 1.1 msec, p < 0.05). There was a precipitous decrease in the amplitude or voltage of the ipsilateral P 2 -MN complex immediately after occlusion (5.32 ± 0.4 µ V before compared to 0.98 ± 0.3 µ V after occlusion, p < 0.001). Therefore, the central latencies and cortical amplitudes of the SEP's are sensitive experimental tools as indicators of the onset and extent of a cerebral ischemic insult." @default.
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- W2023301949 date "1985-02-01" @default.
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- W2023301949 title "Somatosensory evoked potentials as a measure of experimental cerebral ischemia" @default.
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- W2023301949 doi "https://doi.org/10.3171/jns.1985.62.2.0269" @default.
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