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• W2023302219 endingPage "55" @default.
• W2023302219 startingPage "49" @default.
• W2023302219 abstract "Human malignant mesothelioma (HMM) is a fatal tumor and is poorly responsive to current therapeutic regimens. The insulin-like growth factor 1 receptor (IGF-1R) pathway is activated in HMM cell lines and tissues. Treatment with AG1024, an inhibitor of the IGF-1R pathway, significantly decreased cell proliferation and attenuated the phosphorylation of Akt and p44/42. In addition, it significantly enhanced the cytotoxic effects of cisplatin in HMM cell lines. This study supports the conjecture that inhibition of the IGF-1R pathway may be a useful target for reducing toxicity and alleviating chemoresistance to traditional anticancer drugs in HMM patients." @default.
• W2023302219 created "2016-06-24" @default.
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• W2023302219 date "2009-06-01" @default.
• W2023302219 modified "2023-09-25" @default.
• W2023302219 title "Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines" @default.
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• W2023302219 doi "https://doi.org/10.1016/j.canlet.2008.12.023" @default.
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