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- W2023302833 abstract "1820 The presence of leptin resistance was previously reported in both obese adults and children. However, there have been few reports evaluating the influence of weight-reducing program combined with exercise on serum leptin levels. In the present study, we administered a weight-reducing program consisting of exercise and diet treatment to severely obese children and evaluated their body fat distributions, serum leptin levels and risk factors for chronic diseases before and after treatment. Subjects consisted of 7 pediatric inpatients with simple obesity (mean age 10.6 years) who had been hospitalized for a long time. As the weight-reducing program, an aerobic exercise using lightweight dumbbells and a stepping platform as well as diet therapy corresponding to the individual degree of obesity were performed for 11 weeks. Areas of subcutaneous and visceral fats were quantitatively determined using CT images. Blood samples were collected during early morning, and risk factors for chronic diseases, such as serum levels of leptin, TG, HDL-C, LDL-C and uric acid were determined. After completing the weight-reducing program, both areas of subcutaneous and visceral fats obtained from CT images were significantly decreased. Many items relating to chronic diseases, such as serum levels of lipids, hepatic enzymes and uric acid improved. After completing the weight-reducing program, serum leptin levels were significantly decreased (14.4 ng/ml -> 5.1 ng/ml, p <0.01). There was a strong positive correlation between the reduction rate of serum leptin levels and that of total fat areas obtained from abdominal CT images (r = 0.904, p <0.05). Moreover, serum leptin levels per unit of fat mass obtained after the weight-reducing program tended to be lower than those obtained before treatment. These results suggested that the combination of diet and exercise treatment for obese children might contribute to decreasing body fat mass and risk factors for chronic diseases as well as improving leptin resistance." @default.
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- W2023302833 title "INFLUENCE OF EXERCISE TREATMENT ON SERUM LEPTIN LEVELS IN OBESE CHILDREN" @default.
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