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• W2023304218 abstract "Abstract The grades of neurosensory adverse events ( NSAE s) induced by FOLFOX 4 treatment were compared between A sian and W estern colorectal cancer patients and correlated with cumulative oxaliplatin doses. A total of 3359 patients treated with FOLFOX 4 were analyzed: 1515 from two A sian studies ( J apanese Post Marketing Surveillance [ J‐PMS ] and MASCOT ) and 1844 from four W estern studies ( EFC 2962, N9741, EFC 4584, and MOSAIC ). The onset of NSAE s was analyzed in terms of treatment duration and cumulative dose of oxaliplatin. The incidence of grade ≥3 NSAE s ranged from 2.0% to 4.4% in A sian studies and 9.3% to 19% in W estern studies. The cumulative doses of oxaliplatin that induced grade ≥3 NSAE s in 10% of patients were higher in A sian studies (1526 mg/m 2 or not reached) than in W estern studies (805–832 mg/m 2 ). No significant correlations were noted between occurrence of grade ≥3 NSAE s and demographic/baseline characteristics. The frequency of escalation from grade 0 to 1 in J‐PMS was statistically significantly lower than that in EFC 4584, and that from grade 0 to 1 and from grade 1 to 2 in MASCOT lower than that in MOSAIC . The cumulative oxaliplatin doses administered during grade escalation in J‐PMS were similar to those in EFC 2962 or EFC 4584. All grade‐3 NSAE s in MASCOT and 96% of those in MOSAIC improved to grade 2 or less within 12 months of follow‐up. The A sian populations accrued to these studies appear to be less susceptible to the neurotoxicity of oxaliplatin than the mainly C aucasian populations in the W estern studies." @default.
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• W2023304218 date "2012-08-06" @default.
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• W2023304218 title "Analysis of neurosensory adverse events induced by <scp>FOLFOX</scp> 4 treatment in colorectal cancer patients: a comparison between two <scp>A</scp> sian studies and four <scp>W</scp> estern studies" @default.
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• W2023304218 doi "https://doi.org/10.1002/cam4.25" @default.
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