Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023304225> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2023304225 endingPage "539" @default.
- W2023304225 startingPage "531" @default.
- W2023304225 abstract "In a previous study, a mouse L cell mutant was isolated which is 90% resistant to HSV-1 infection (S. Gruenheid, L. Gatzke, H. Meadows, and F. Tufaro. J. Virol. 67, 93-100, 1993). This cell line, termed gro2C, failed to express heparan sulfate (HS) glycosaminoglycans on the cell surface, which normally act as initial receptors for HSV-1 attachment to cultured cells. In this report, we extended the characterization of gro2C cells to explore the possibility that cell-surface chondroitin sulfate (CS) facilitates virus attachment to gro2C cells in the absence of HS. We found that soluble CS types A, B, and C strongly interfere with adsorption of HSV-1 to the surface of gro2C cells in a dose-dependent manner, and CS type B (dermatan sulfate) inhibited adsorption to parental (control) L cells by up to 10%. Moreover, gro2C cell infection was hypersensitive to inhibition by HS in comparison to control L cell infection. In all cases, a decrease in adsorption resulted in a decrease in infection. By contrast, the highly-sulfated glycosaminoglycan analog dextran sulfate was a relatively poor inhibitor of gro2C cell infection, indicating that the inhibitory effects of CS were related to its carbohydrate structure and not solely to its strong negative charge. By using a mutant virus strain which does not express the heparin-binding glycoprorein gC, we show that gC was not required for infection of gro2C cells, and was not required for the inhibition by HS or CS. Thus, the characterization of gro2C cell infection has revealed that one or more components of the HSV-1 particle can interact with cell-surface CS as well as HS to mediate infection of susceptible cells." @default.
- W2023304225 created "2016-06-24" @default.
- W2023304225 creator A5000905082 @default.
- W2023304225 creator A5030973061 @default.
- W2023304225 creator A5064085052 @default.
- W2023304225 creator A5065735862 @default.
- W2023304225 creator A5082646052 @default.
- W2023304225 creator A5087270298 @default.
- W2023304225 date "1995-04-01" @default.
- W2023304225 modified "2023-09-30" @default.
- W2023304225 title "Evidence for an Interaction of Herpes Simplex Virus with Chondroitin Sulfate Proteoglycans during Infection" @default.
- W2023304225 doi "https://doi.org/10.1006/viro.1995.1184" @default.
- W2023304225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7747425" @default.
- W2023304225 hasPublicationYear "1995" @default.
- W2023304225 type Work @default.
- W2023304225 sameAs 2023304225 @default.
- W2023304225 citedByCount "84" @default.
- W2023304225 countsByYear W20233042252012 @default.
- W2023304225 countsByYear W20233042252013 @default.
- W2023304225 countsByYear W20233042252014 @default.
- W2023304225 countsByYear W20233042252017 @default.
- W2023304225 countsByYear W20233042252018 @default.
- W2023304225 countsByYear W20233042252019 @default.
- W2023304225 countsByYear W20233042252020 @default.
- W2023304225 countsByYear W20233042252021 @default.
- W2023304225 countsByYear W20233042252022 @default.
- W2023304225 countsByYear W20233042252023 @default.
- W2023304225 crossrefType "journal-article" @default.
- W2023304225 hasAuthorship W2023304225A5000905082 @default.
- W2023304225 hasAuthorship W2023304225A5030973061 @default.
- W2023304225 hasAuthorship W2023304225A5064085052 @default.
- W2023304225 hasAuthorship W2023304225A5065735862 @default.
- W2023304225 hasAuthorship W2023304225A5082646052 @default.
- W2023304225 hasAuthorship W2023304225A5087270298 @default.
- W2023304225 hasBestOaLocation W20233042251 @default.
- W2023304225 hasConcept C104317684 @default.
- W2023304225 hasConcept C143065580 @default.
- W2023304225 hasConcept C1491633281 @default.
- W2023304225 hasConcept C153074725 @default.
- W2023304225 hasConcept C153911025 @default.
- W2023304225 hasConcept C159047783 @default.
- W2023304225 hasConcept C2522874641 @default.
- W2023304225 hasConcept C2777557582 @default.
- W2023304225 hasConcept C2778041096 @default.
- W2023304225 hasConcept C2778066728 @default.
- W2023304225 hasConcept C2779553658 @default.
- W2023304225 hasConcept C2781196997 @default.
- W2023304225 hasConcept C54355233 @default.
- W2023304225 hasConcept C55493867 @default.
- W2023304225 hasConcept C81885089 @default.
- W2023304225 hasConcept C86803240 @default.
- W2023304225 hasConceptScore W2023304225C104317684 @default.
- W2023304225 hasConceptScore W2023304225C143065580 @default.
- W2023304225 hasConceptScore W2023304225C1491633281 @default.
- W2023304225 hasConceptScore W2023304225C153074725 @default.
- W2023304225 hasConceptScore W2023304225C153911025 @default.
- W2023304225 hasConceptScore W2023304225C159047783 @default.
- W2023304225 hasConceptScore W2023304225C2522874641 @default.
- W2023304225 hasConceptScore W2023304225C2777557582 @default.
- W2023304225 hasConceptScore W2023304225C2778041096 @default.
- W2023304225 hasConceptScore W2023304225C2778066728 @default.
- W2023304225 hasConceptScore W2023304225C2779553658 @default.
- W2023304225 hasConceptScore W2023304225C2781196997 @default.
- W2023304225 hasConceptScore W2023304225C54355233 @default.
- W2023304225 hasConceptScore W2023304225C55493867 @default.
- W2023304225 hasConceptScore W2023304225C81885089 @default.
- W2023304225 hasConceptScore W2023304225C86803240 @default.
- W2023304225 hasIssue "2" @default.
- W2023304225 hasLocation W20233042251 @default.
- W2023304225 hasLocation W20233042252 @default.
- W2023304225 hasOpenAccess W2023304225 @default.
- W2023304225 hasPrimaryLocation W20233042251 @default.
- W2023304225 hasRelatedWork W1513835358 @default.
- W2023304225 hasRelatedWork W1965553541 @default.
- W2023304225 hasRelatedWork W1986608599 @default.
- W2023304225 hasRelatedWork W1995003331 @default.
- W2023304225 hasRelatedWork W2027388071 @default.
- W2023304225 hasRelatedWork W2044864133 @default.
- W2023304225 hasRelatedWork W2061776538 @default.
- W2023304225 hasRelatedWork W2164865932 @default.
- W2023304225 hasRelatedWork W2416959023 @default.
- W2023304225 hasRelatedWork W2483299955 @default.
- W2023304225 hasVolume "208" @default.
- W2023304225 isParatext "false" @default.
- W2023304225 isRetracted "false" @default.
- W2023304225 magId "2023304225" @default.
- W2023304225 workType "article" @default.