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- W2023304660 endingPage "371" @default.
- W2023304660 startingPage "343" @default.
- W2023304660 abstract "SUMMARY The aim of this review is to present the current state of knowledge on human latent tuberculosis infection (LTBI) based on clinical studies and observations, as well as experimental in vitro and animal models. Several key terms are defined, including “latency,” “persistence,” “dormancy,” and “antibiotic tolerance.” Dogmas prevalent in the field are critically examined based on available clinical and experimental data, including the long-held beliefs that infection is either latent or active, that LTBI represents a small population of nonreplicating, “dormant” bacilli, and that caseous granulomas are the haven for LTBI. The role of host factors, such as CD4 + and CD8 + T cells, T regulatory cells, tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ), in controlling TB infection is discussed. We also highlight microbial regulatory and metabolic pathways implicated in bacillary growth restriction and antibiotic tolerance under various physiologically relevant conditions. Finally, we pose several clinically important questions, which remain unanswered and will serve to stimulate future research on LTBI." @default.
- W2023304660 created "2016-06-24" @default.
- W2023304660 creator A5000064910 @default.
- W2023304660 creator A5011032997 @default.
- W2023304660 date "2014-09-01" @default.
- W2023304660 modified "2023-10-12" @default.
- W2023304660 title "Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms" @default.
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