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- W2023305864 abstract "The role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin was studied by measuiing the enzyme activity of the tibia of rats following the administration of PTH and/or calcitonin. Calcitonin caused a significant and rapid increase in the pyrophosphatase activity of the tibia which preceded the development of significant hypocalcemia. PTH, on the other hand, significantly decreased the enzyme activity of the tibia in thyroparathyroidectomized rats. These results suggest that the alteration of pyrophosphatase activity is directly involved in the mechanism of action of calcitonin and PTH. In view of the fact that pyrophosphate plays a key role in the regulation of bone formation through the inhibition of calcification, as has been suggested by Fleisch et al., its removal by pyrophosphatase would facilitate bone mineralization. (Endocrinology89: 852,1971)" @default.
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- W2023305864 date "1971-09-01" @default.
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- W2023305864 title "Role of Inorganic Pyrophosphatase in the Mechanism of Action of Parathyroid Hormone and Calcitonin" @default.
- W2023305864 doi "https://doi.org/10.1210/endo-89-3-852" @default.
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