Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023306174> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2023306174 endingPage "266" @default.
- W2023306174 startingPage "261" @default.
- W2023306174 abstract "This study was undertaken to investigate the role of endothelium in the modulation of vascular responses to bradykinin and to clucidate the receptor types and mechanism of action of bradykinin in isolated basilar artery. The results showed a contractile response to hradykinin in basilar artery. This contractile response to bradykinin was partially modulated by endothelium in a dose-dependent manner. In addition, both des-Arg9-[Leu8]bradykinin and [d-Arg0,Hyp3,Thi5,8,D-Phe7]bradykinin significantly antagonized the responses to bradykinin. However, the blocking effect and the apparent affinity of [d-Arg0,Hyp3, Thi5,8.D-Phe7bradykinin (pA2 = 9.6 ± 0.4) were greater than those with des-Arg9[Leu8]bradykinin (pA2 = 7.S ± 0.3). These results suggest that two apparently distinct types of BK receptors may exist in basilar artcrics. Furthermore, the contractile response to bradykinin in basilar artery was significantly inhibited hy 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamatc (10−5 M). H-7 (10−5M) and TMB-8 (10−5 M), but not by indomcthacin (10−5 M) or nordihydroquariarctic acid (10−5 M). On the other hand. nifedipine. Ca2+-free medium, EGTA and Ca2+-free medium/EGTA significantly reduced the bradykinin-induced contraction. indicating that part of the contractile response of basilar artery to bradykinin is dependent on extracellular Ca2+. In conclusion, the mechanism of the contractile responses to bradykinin in basilar artery may involve increased intracellular Ca2+ levels acting on the Bk1 and BK2 receptor, followed by activation of the phosphoinositide pathway and receptor-mediated Ca2+ channel." @default.
- W2023306174 created "2016-06-24" @default.
- W2023306174 creator A5009374460 @default.
- W2023306174 creator A5060525354 @default.
- W2023306174 date "1992-10-01" @default.
- W2023306174 modified "2023-10-18" @default.
- W2023306174 title "Mechanism of contractile responses to bradykinin in canine basilar arteries" @default.
- W2023306174 cites W1495233477 @default.
- W2023306174 cites W1498058603 @default.
- W2023306174 cites W1927532555 @default.
- W2023306174 cites W1965286434 @default.
- W2023306174 cites W1977477833 @default.
- W2023306174 cites W1978321945 @default.
- W2023306174 cites W1992028820 @default.
- W2023306174 cites W1993551565 @default.
- W2023306174 cites W1995243710 @default.
- W2023306174 cites W1999470783 @default.
- W2023306174 cites W2005348762 @default.
- W2023306174 cites W2011880345 @default.
- W2023306174 cites W2018909032 @default.
- W2023306174 cites W2049728051 @default.
- W2023306174 cites W2054480215 @default.
- W2023306174 cites W2065852536 @default.
- W2023306174 cites W2068877244 @default.
- W2023306174 cites W2072099683 @default.
- W2023306174 cites W2089345256 @default.
- W2023306174 cites W2089531208 @default.
- W2023306174 cites W2117002716 @default.
- W2023306174 cites W2128321979 @default.
- W2023306174 cites W2337457843 @default.
- W2023306174 cites W4232414191 @default.
- W2023306174 cites W4244024065 @default.
- W2023306174 doi "https://doi.org/10.1016/0014-2999(92)90711-c" @default.
- W2023306174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1330625" @default.
- W2023306174 hasPublicationYear "1992" @default.
- W2023306174 type Work @default.
- W2023306174 sameAs 2023306174 @default.
- W2023306174 citedByCount "11" @default.
- W2023306174 countsByYear W20233061742021 @default.
- W2023306174 crossrefType "journal-article" @default.
- W2023306174 hasAuthorship W2023306174A5009374460 @default.
- W2023306174 hasAuthorship W2023306174A5060525354 @default.
- W2023306174 hasConcept C126322002 @default.
- W2023306174 hasConcept C134018914 @default.
- W2023306174 hasConcept C153939273 @default.
- W2023306174 hasConcept C170493617 @default.
- W2023306174 hasConcept C185592680 @default.
- W2023306174 hasConcept C2777658833 @default.
- W2023306174 hasConcept C2779591629 @default.
- W2023306174 hasConcept C2781012200 @default.
- W2023306174 hasConcept C519063684 @default.
- W2023306174 hasConcept C71924100 @default.
- W2023306174 hasConcept C86803240 @default.
- W2023306174 hasConceptScore W2023306174C126322002 @default.
- W2023306174 hasConceptScore W2023306174C134018914 @default.
- W2023306174 hasConceptScore W2023306174C153939273 @default.
- W2023306174 hasConceptScore W2023306174C170493617 @default.
- W2023306174 hasConceptScore W2023306174C185592680 @default.
- W2023306174 hasConceptScore W2023306174C2777658833 @default.
- W2023306174 hasConceptScore W2023306174C2779591629 @default.
- W2023306174 hasConceptScore W2023306174C2781012200 @default.
- W2023306174 hasConceptScore W2023306174C519063684 @default.
- W2023306174 hasConceptScore W2023306174C71924100 @default.
- W2023306174 hasConceptScore W2023306174C86803240 @default.
- W2023306174 hasIssue "2-3" @default.
- W2023306174 hasLocation W20233061741 @default.
- W2023306174 hasLocation W20233061742 @default.
- W2023306174 hasOpenAccess W2023306174 @default.
- W2023306174 hasPrimaryLocation W20233061741 @default.
- W2023306174 hasRelatedWork W2003842308 @default.
- W2023306174 hasRelatedWork W2018368842 @default.
- W2023306174 hasRelatedWork W2023306174 @default.
- W2023306174 hasRelatedWork W2033472167 @default.
- W2023306174 hasRelatedWork W2034583712 @default.
- W2023306174 hasRelatedWork W2063619316 @default.
- W2023306174 hasRelatedWork W2064236298 @default.
- W2023306174 hasRelatedWork W2095093072 @default.
- W2023306174 hasRelatedWork W2169225653 @default.
- W2023306174 hasRelatedWork W2414846389 @default.
- W2023306174 hasVolume "221" @default.
- W2023306174 isParatext "false" @default.
- W2023306174 isRetracted "false" @default.
- W2023306174 magId "2023306174" @default.
- W2023306174 workType "article" @default.