Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023306397> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2023306397 abstract "Classically envisioned as a key mediator in allergic reactions, histamine has been recently suggested to play a role in central nervous system (CNS) autoimmune responses occurring in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), animal model for this disease. Studies performed with histamine receptors or histidine-decarboxylase knockout mice have shown that histamine can play promoting or protective roles in EAE depending on the receptors engaged. Moreover, transcript levels of histamine receptors are significantly modulated in peripheral T cells in different stages of EAE. In order to determine whether these findings could be of relevance for the human disease, in the present study we analysed the gene expression of histamine receptor 1 (HRH1), HRH2 and HRH4 in peripheral blood mononuclear cells derived from patients with clinically isolated syndrome (CIS), relapsing–remitting (RR), secondaryprogressive (SP), primary-progressive (PP) MS, and healthy controls (HC). HRH3 has not been included in our study, as its expression is restricted to the CNS. Histamine receptors were all expressed at mRNA level and HRH2 transcripts were always more abundant than those for HRH4 and HRH1 in the analysed groups. Interestingly, we found that HRH1 transcript was significantly downmodulated in SP-MS compared with HC (p b 0.05), and HRH4 was increased in this group compared to HC (p b 0.05), CIS (p= 0.01) and SM-RR (p b 0.05). No other differences in the expression of histamine receptors were observed between HC, CIS or other clinical forms of definite MS. These results show that histamine receptors are differentially expressed in SP-MS." @default.
- W2023306397 created "2016-06-24" @default.
- W2023306397 creator A5004927382 @default.
- W2023306397 creator A5011814326 @default.
- W2023306397 creator A5021775232 @default.
- W2023306397 creator A5056651546 @default.
- W2023306397 creator A5085016094 @default.
- W2023306397 date "2014-10-01" @default.
- W2023306397 modified "2023-09-26" @default.
- W2023306397 title "Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from clinically-isolated syndrome and multiple sclerosis patients" @default.
- W2023306397 doi "https://doi.org/10.1016/j.jneuroim.2014.08.390" @default.
- W2023306397 hasPublicationYear "2014" @default.
- W2023306397 type Work @default.
- W2023306397 sameAs 2023306397 @default.
- W2023306397 citedByCount "0" @default.
- W2023306397 crossrefType "journal-article" @default.
- W2023306397 hasAuthorship W2023306397A5004927382 @default.
- W2023306397 hasAuthorship W2023306397A5011814326 @default.
- W2023306397 hasAuthorship W2023306397A5021775232 @default.
- W2023306397 hasAuthorship W2023306397A5056651546 @default.
- W2023306397 hasAuthorship W2023306397A5085016094 @default.
- W2023306397 hasConcept C10335311 @default.
- W2023306397 hasConcept C1122143 @default.
- W2023306397 hasConcept C126322002 @default.
- W2023306397 hasConcept C134018914 @default.
- W2023306397 hasConcept C137061746 @default.
- W2023306397 hasConcept C159545944 @default.
- W2023306397 hasConcept C170493617 @default.
- W2023306397 hasConcept C181199279 @default.
- W2023306397 hasConcept C192233252 @default.
- W2023306397 hasConcept C202751555 @default.
- W2023306397 hasConcept C203014093 @default.
- W2023306397 hasConcept C2776885963 @default.
- W2023306397 hasConcept C2777899865 @default.
- W2023306397 hasConcept C2778460671 @default.
- W2023306397 hasConcept C2778486448 @default.
- W2023306397 hasConcept C2780640218 @default.
- W2023306397 hasConcept C30862142 @default.
- W2023306397 hasConcept C34400551 @default.
- W2023306397 hasConcept C55493867 @default.
- W2023306397 hasConcept C71924100 @default.
- W2023306397 hasConcept C86803240 @default.
- W2023306397 hasConceptScore W2023306397C10335311 @default.
- W2023306397 hasConceptScore W2023306397C1122143 @default.
- W2023306397 hasConceptScore W2023306397C126322002 @default.
- W2023306397 hasConceptScore W2023306397C134018914 @default.
- W2023306397 hasConceptScore W2023306397C137061746 @default.
- W2023306397 hasConceptScore W2023306397C159545944 @default.
- W2023306397 hasConceptScore W2023306397C170493617 @default.
- W2023306397 hasConceptScore W2023306397C181199279 @default.
- W2023306397 hasConceptScore W2023306397C192233252 @default.
- W2023306397 hasConceptScore W2023306397C202751555 @default.
- W2023306397 hasConceptScore W2023306397C203014093 @default.
- W2023306397 hasConceptScore W2023306397C2776885963 @default.
- W2023306397 hasConceptScore W2023306397C2777899865 @default.
- W2023306397 hasConceptScore W2023306397C2778460671 @default.
- W2023306397 hasConceptScore W2023306397C2778486448 @default.
- W2023306397 hasConceptScore W2023306397C2780640218 @default.
- W2023306397 hasConceptScore W2023306397C30862142 @default.
- W2023306397 hasConceptScore W2023306397C34400551 @default.
- W2023306397 hasConceptScore W2023306397C55493867 @default.
- W2023306397 hasConceptScore W2023306397C71924100 @default.
- W2023306397 hasConceptScore W2023306397C86803240 @default.
- W2023306397 hasLocation W20233063971 @default.
- W2023306397 hasOpenAccess W2023306397 @default.
- W2023306397 hasPrimaryLocation W20233063971 @default.
- W2023306397 hasRelatedWork W1430758748 @default.
- W2023306397 hasRelatedWork W1484994299 @default.
- W2023306397 hasRelatedWork W1570269285 @default.
- W2023306397 hasRelatedWork W1834753894 @default.
- W2023306397 hasRelatedWork W1987703530 @default.
- W2023306397 hasRelatedWork W2008577620 @default.
- W2023306397 hasRelatedWork W2015495611 @default.
- W2023306397 hasRelatedWork W2026361878 @default.
- W2023306397 hasRelatedWork W2031850545 @default.
- W2023306397 hasRelatedWork W2058078642 @default.
- W2023306397 hasRelatedWork W2058600161 @default.
- W2023306397 hasRelatedWork W2065999598 @default.
- W2023306397 hasRelatedWork W2072992243 @default.
- W2023306397 hasRelatedWork W2085564028 @default.
- W2023306397 hasRelatedWork W2143953865 @default.
- W2023306397 hasRelatedWork W2152093727 @default.
- W2023306397 hasRelatedWork W2558506950 @default.
- W2023306397 hasRelatedWork W2800776367 @default.
- W2023306397 hasRelatedWork W2986298172 @default.
- W2023306397 hasRelatedWork W186742079 @default.
- W2023306397 isParatext "false" @default.
- W2023306397 isRetracted "false" @default.
- W2023306397 magId "2023306397" @default.
- W2023306397 workType "article" @default.