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• W2023306911 abstract "This paper analyzes the equilibria involved in the dimerization of monomeric receptors with homo-bifunctional ligands. We provide analytical expressions that can be used to estimate the concentration of each species present in a mixture of homo-bifunctional ligand and monomeric proteins, given initial conditions defining the total concentration of bivalent ligand [L2]0, the total concentration of protein [P]0, one dissociation constant Kd, and a parameter to account for cooperativity α. We demonstrate that the fraction of protein present in a complex of two proteins and one bivalent ligand (P·L2·P) is maximized at [L2]0 = Kd/2 + [P]0/2." @default.
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• W2023306911 date "2008-06-11" @default.
• W2023306911 modified "2023-09-22" @default.
• W2023306911 title "Exact Analysis of Ligand-Induced Dimerization of Monomeric Receptors" @default.
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• W2023306911 doi "https://doi.org/10.1021/ac800578w" @default.
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