Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023307139> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2023307139 endingPage "302" @default.
- W2023307139 startingPage "294" @default.
- W2023307139 abstract "Colorectal cancer frequently disseminates through the portal vein into the liver. In this study, outbred Swiss nude mice were adapted to facilitate the induction of liver metastases by a pre-grafting treatment with 6 Gy total body irradiation and i.v. injection of anti-asialo GMI antibody. One day later, cultured LS 174T human colon cancer cells were injected into the surgically exposed spleen, which was resected 3 min later. In 48 of 65 mice, a few to several hundred liver metastases were macroscopically observed at dissection 3 to 4 weeks after transplantation. Ten of 10 mice, followed-up for survival, died with multiple large confluent liver metastases. By reducing the radiation dose to 4 or 0 Gy, or omitting the anti-asialo GMI antibody injection, only 60%, 37% or 50% of mice, respectively, had visible metastases 3 weeks after transplantation. Carcinoembryonic antigen (CEA) measured in tumour extracts was in the mean 25.6 μg/g in liver metastases compared with 9.2 μg/g in s.c. tumours. Uptake of radiolabelled anti-CEA monoclonal antibody (MAb) in the metastases 12, 24 and 48 hr after injection gave a mean value of 39% of the injected dose per gram of tissue (ID/g). In comparison, MAb uptake in s.c. and intrasplenic tumours or lung metastases gave a mean percentage ID/g of 20, 18 and 15, respectively. Laser-induced fluorescence after injection of Indocyanin-MAb conjugate allowed direct visual detection of small liver metastases, including some that were not visible under normal light. Preliminary results showed that mice, pre-treated with 4 Gy irradiation and the anti-asialo GMI injection, were tolerant to radioimmunotherapy with a total dose of 500 μCi 131I labeled anti-CEA intact MAbs given in 3 injections. © 1996 Wiley-Liss, Inc." @default.
- W2023307139 created "2016-06-24" @default.
- W2023307139 creator A5004334252 @default.
- W2023307139 creator A5006190775 @default.
- W2023307139 creator A5008423807 @default.
- W2023307139 creator A5011351923 @default.
- W2023307139 creator A5055969947 @default.
- W2023307139 creator A5066218901 @default.
- W2023307139 creator A5074719854 @default.
- W2023307139 creator A5079396804 @default.
- W2023307139 creator A5080479738 @default.
- W2023307139 creator A5082011377 @default.
- W2023307139 date "1996-07-17" @default.
- W2023307139 modified "2023-10-16" @default.
- W2023307139 title "Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice: A model for radioimmunotherapy" @default.
- W2023307139 cites W1970060529 @default.
- W2023307139 cites W1975629024 @default.
- W2023307139 cites W2013217786 @default.
- W2023307139 cites W2048097813 @default.
- W2023307139 cites W2052600111 @default.
- W2023307139 cites W2056397944 @default.
- W2023307139 cites W2078966922 @default.
- W2023307139 cites W2092110872 @default.
- W2023307139 cites W2109456792 @default.
- W2023307139 cites W2289905828 @default.
- W2023307139 cites W2336798756 @default.
- W2023307139 doi "https://doi.org/10.1002/(sici)1097-0215(19960717)67:2<294::aid-ijc23>3.0.co;2-a" @default.
- W2023307139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8760602" @default.
- W2023307139 hasPublicationYear "1996" @default.
- W2023307139 type Work @default.
- W2023307139 sameAs 2023307139 @default.
- W2023307139 citedByCount "18" @default.
- W2023307139 countsByYear W20233071392013 @default.
- W2023307139 countsByYear W20233071392019 @default.
- W2023307139 countsByYear W20233071392020 @default.
- W2023307139 crossrefType "journal-article" @default.
- W2023307139 hasAuthorship W2023307139A5004334252 @default.
- W2023307139 hasAuthorship W2023307139A5006190775 @default.
- W2023307139 hasAuthorship W2023307139A5008423807 @default.
- W2023307139 hasAuthorship W2023307139A5011351923 @default.
- W2023307139 hasAuthorship W2023307139A5055969947 @default.
- W2023307139 hasAuthorship W2023307139A5066218901 @default.
- W2023307139 hasAuthorship W2023307139A5074719854 @default.
- W2023307139 hasAuthorship W2023307139A5079396804 @default.
- W2023307139 hasAuthorship W2023307139A5080479738 @default.
- W2023307139 hasAuthorship W2023307139A5082011377 @default.
- W2023307139 hasBestOaLocation W20233071391 @default.
- W2023307139 hasConcept C121608353 @default.
- W2023307139 hasConcept C126322002 @default.
- W2023307139 hasConcept C142724271 @default.
- W2023307139 hasConcept C159654299 @default.
- W2023307139 hasConcept C203014093 @default.
- W2023307139 hasConcept C2776146153 @default.
- W2023307139 hasConcept C2776869981 @default.
- W2023307139 hasConcept C2777387746 @default.
- W2023307139 hasConcept C2780278673 @default.
- W2023307139 hasConcept C2780931953 @default.
- W2023307139 hasConcept C2911091166 @default.
- W2023307139 hasConcept C3019217517 @default.
- W2023307139 hasConcept C526805850 @default.
- W2023307139 hasConcept C542903549 @default.
- W2023307139 hasConcept C71924100 @default.
- W2023307139 hasConceptScore W2023307139C121608353 @default.
- W2023307139 hasConceptScore W2023307139C126322002 @default.
- W2023307139 hasConceptScore W2023307139C142724271 @default.
- W2023307139 hasConceptScore W2023307139C159654299 @default.
- W2023307139 hasConceptScore W2023307139C203014093 @default.
- W2023307139 hasConceptScore W2023307139C2776146153 @default.
- W2023307139 hasConceptScore W2023307139C2776869981 @default.
- W2023307139 hasConceptScore W2023307139C2777387746 @default.
- W2023307139 hasConceptScore W2023307139C2780278673 @default.
- W2023307139 hasConceptScore W2023307139C2780931953 @default.
- W2023307139 hasConceptScore W2023307139C2911091166 @default.
- W2023307139 hasConceptScore W2023307139C3019217517 @default.
- W2023307139 hasConceptScore W2023307139C526805850 @default.
- W2023307139 hasConceptScore W2023307139C542903549 @default.
- W2023307139 hasConceptScore W2023307139C71924100 @default.
- W2023307139 hasIssue "2" @default.
- W2023307139 hasLocation W20233071391 @default.
- W2023307139 hasLocation W20233071392 @default.
- W2023307139 hasOpenAccess W2023307139 @default.
- W2023307139 hasPrimaryLocation W20233071391 @default.
- W2023307139 hasRelatedWork W1516113149 @default.
- W2023307139 hasRelatedWork W1517145497 @default.
- W2023307139 hasRelatedWork W1973774944 @default.
- W2023307139 hasRelatedWork W2001037779 @default.
- W2023307139 hasRelatedWork W2026267622 @default.
- W2023307139 hasRelatedWork W2056526459 @default.
- W2023307139 hasRelatedWork W2093273184 @default.
- W2023307139 hasRelatedWork W2107017278 @default.
- W2023307139 hasRelatedWork W2139641734 @default.
- W2023307139 hasRelatedWork W2465136625 @default.
- W2023307139 hasVolume "67" @default.
- W2023307139 isParatext "false" @default.
- W2023307139 isRetracted "false" @default.
- W2023307139 magId "2023307139" @default.
- W2023307139 workType "article" @default.