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• W2023311060 abstract "No AccessJournal of UrologyReconstruction1 Oct 2010Is Oral Vitamin B12 Therapy Effective for Vitamin B12 Deficiency in Patients With Prior Ileocystoplasty? Brian A. VanderBrink, Mark P. Cain, Shelly King, Kirstan Meldrum, Martin Kaefer, Rosalia Misseri, Deanna Jones, and Richard C. Rink Brian A. VanderBrinkBrian A. VanderBrink More articles by this author , Mark P. CainMark P. Cain More articles by this author , Shelly KingShelly King More articles by this author , Kirstan MeldrumKirstan Meldrum More articles by this author , Martin KaeferMartin Kaefer More articles by this author , Rosalia MisseriRosalia Misseri More articles by this author , Deanna JonesDeanna Jones More articles by this author , and Richard C. RinkRichard C. Rink Financial interest and/or other relationship with Boehringer-Ingelheim. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.05.049AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We previously identified vitamin B12 deficiency as a potential long-term consequence in pediatric patients with prior ileocystoplasty despite adequate preservation of terminal ileum. Vitamin B12 deficiency can result in hematological and neurological deficits, of which some are irreversible. Deficiency discovered after ileocystoplasty is purportedly due to B12 malabsorption since the principal absorption site is ileum. B12 deficiency due to malabsorption is typically treated with intramuscular injection to ensure adequate treatment. We determined whether oral vitamin B12 supplementation could increase serum vitamin B12 in patients with deficiency who underwent ileocystoplasty. Materials and Methods: During followup after ileocystoplasty we identified patients with low (200 pg/dl or less) or low normal (200 to 300 pg/dl) vitamin B12. Oral vitamin B12 was begun at 250 μg. Serum B12 was assessed at 1, 2 and 3-month intervals after beginning therapy. Results: A total of 128 patients with a mean followup of 83 months after ileocystoplasty had vitamin B12 levels available for review. Of these patients 36 (28%) had a level of 300 pg/dl or less with a level of 200 pg/dl or less in 16 (13%). After oral vitamin B12 treatment serum levels increased from a mean 235 to 506 pg/dl (114%) upon initial measurement (p <0.001). Subsequent measurements continued to increase from the first posttreatment level (p <0.05). No adverse effects were noted during a mean 4-month followup. Conclusions: To our knowledge this is the first study to show that oral vitamin B12 effectively increases serum levels in pediatric patients with prior ileocystoplasty. 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Google Scholar Department of Urology, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 184Issue 4SOctober 2010Page: 1781-1785 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Keywordsoralneurogenicurinary bladderadministrationvitamin B 12avitaminosisileumMetricsAuthor Information Brian A. VanderBrink More articles by this author Mark P. Cain More articles by this author Shelly King More articles by this author Kirstan Meldrum More articles by this author Martin Kaefer More articles by this author Rosalia Misseri More articles by this author Deanna Jones More articles by this author Richard C. Rink Financial interest and/or other relationship with Boehringer-Ingelheim. More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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