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• W2023311507 abstract "En estudios aleatorizados amplios se ha establecido que un control intensivo temprano de la glucemia reduce el riesgo de complicaciones diabéticas, tanto microvasculares como macrovasculares. Sin embargo, los datos epidemiológicos y prospectivos respaldan la existencia de una influencia a largo plazo del control metabólico inicial sobre la evolución clínica posterior. A este fenómeno se le ha denominado recientemente “memoria metabólica”. Los posibles mecanismos para la propagación de esta “memoria” son la glicación no enzimática de proteínas y lípidos celulares, y el exceso de especies moleculares de nitrógeno y oxígeno reactivas celulares, en especial las originadas en las proteínas mitocondriales glicadas, que tal vez actúen de manera concertada entre sí para mantener las señales de estrés. Además, la aparición de esta “memoria metabólica” sugiere la necesidad de un tratamiento enérgico muy temprano destinado a “normalizar” el control metabólico y de la adición de fármacos que reduzcan las especies moleculares reactivas celulares y la glicación, además de normalizar las concentraciones de glucosa de los pacientes, para reducir al mínimo las complicaciones diabéticas a largo plazo. Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as “metabolic memory.” Potential mechanisms for propagating this “memory” are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signaling. Furthermore, the emergence of this “metabolic memory” suggests the need of a very early aggressive treatment aiming to “normalize” the metabolic control and the addition of agents which reduce cellular reactive species and glycation in addition to normalizing glucose levels in diabetic patients in order to minimize long-term diabetic complications." @default.
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• W2023311507 date "2008-01-01" @default.
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• W2023311507 title "La “memoria metabólica” inducida por la hiperglucemia: el nuevo reto en la prevención de la enfermedad cardiovascular en la diabetes" @default.
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