Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023317081> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2023317081 endingPage "869" @default.
- W2023317081 startingPage "865" @default.
- W2023317081 abstract "1. The study of the kinetics of cytochrome P-450 loss caused by 2-allyl-2-isopropylacetamide in vivo showed the existence of at least two components: pre-treatment with phenobarbitone markedly increased the amount of the fast decaying component without altering its half-life, but did not change significantly either amount or half-life of the slow decaying component. 2. It is suggested (i) that the two components represent different cytochromes which are destroyed at different rates by 2-allyl-2-isopropylacetamide; and (ii) that phenobarbitone pre-treatment stimulates the destruction of cytochrome P-450 by increasing the concentration in the microsomal fraction of the type of cytochrome which is susceptible to rapid destruction. 3. Exogenous haem was also destroyed when the liver microsomal fraction was incubated with the drug in vitro. This suggests that the action of the drug is not confined to the haem of the preexisting cytochrome P-450 but may extend to other pools of haem in the liver." @default.
- W2023317081 created "2016-06-24" @default.
- W2023317081 creator A5057756242 @default.
- W2023317081 creator A5067248421 @default.
- W2023317081 date "1978-01-01" @default.
- W2023317081 modified "2023-10-03" @default.
- W2023317081 title "Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: Role of the liver cytochrome p-450 which is inducible by phenobarbitone" @default.
- W2023317081 cites W1598667621 @default.
- W2023317081 cites W1598739109 @default.
- W2023317081 cites W1665143716 @default.
- W2023317081 cites W1951469402 @default.
- W2023317081 cites W1969809945 @default.
- W2023317081 cites W1987502513 @default.
- W2023317081 cites W2012171778 @default.
- W2023317081 cites W2013568530 @default.
- W2023317081 cites W2069559473 @default.
- W2023317081 cites W2078295690 @default.
- W2023317081 cites W2086642325 @default.
- W2023317081 cites W2088965897 @default.
- W2023317081 cites W2239608913 @default.
- W2023317081 cites W2303419127 @default.
- W2023317081 cites W2326144331 @default.
- W2023317081 cites W2339213807 @default.
- W2023317081 cites W2047477681 @default.
- W2023317081 doi "https://doi.org/10.1016/0020-711x(78)90061-7" @default.
- W2023317081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/744288" @default.
- W2023317081 hasPublicationYear "1978" @default.
- W2023317081 type Work @default.
- W2023317081 sameAs 2023317081 @default.
- W2023317081 citedByCount "21" @default.
- W2023317081 crossrefType "journal-article" @default.
- W2023317081 hasAuthorship W2023317081A5057756242 @default.
- W2023317081 hasAuthorship W2023317081A5067248421 @default.
- W2023317081 hasBestOaLocation W20233170811 @default.
- W2023317081 hasConcept C121332964 @default.
- W2023317081 hasConcept C148898269 @default.
- W2023317081 hasConcept C150903083 @default.
- W2023317081 hasConcept C16613235 @default.
- W2023317081 hasConcept C181199279 @default.
- W2023317081 hasConcept C185592680 @default.
- W2023317081 hasConcept C202751555 @default.
- W2023317081 hasConcept C207001950 @default.
- W2023317081 hasConcept C20705724 @default.
- W2023317081 hasConcept C2776217839 @default.
- W2023317081 hasConcept C2778793413 @default.
- W2023317081 hasConcept C2780768313 @default.
- W2023317081 hasConcept C55493867 @default.
- W2023317081 hasConcept C62520636 @default.
- W2023317081 hasConcept C86803240 @default.
- W2023317081 hasConcept C87644729 @default.
- W2023317081 hasConcept C98274493 @default.
- W2023317081 hasConceptScore W2023317081C121332964 @default.
- W2023317081 hasConceptScore W2023317081C148898269 @default.
- W2023317081 hasConceptScore W2023317081C150903083 @default.
- W2023317081 hasConceptScore W2023317081C16613235 @default.
- W2023317081 hasConceptScore W2023317081C181199279 @default.
- W2023317081 hasConceptScore W2023317081C185592680 @default.
- W2023317081 hasConceptScore W2023317081C202751555 @default.
- W2023317081 hasConceptScore W2023317081C207001950 @default.
- W2023317081 hasConceptScore W2023317081C20705724 @default.
- W2023317081 hasConceptScore W2023317081C2776217839 @default.
- W2023317081 hasConceptScore W2023317081C2778793413 @default.
- W2023317081 hasConceptScore W2023317081C2780768313 @default.
- W2023317081 hasConceptScore W2023317081C55493867 @default.
- W2023317081 hasConceptScore W2023317081C62520636 @default.
- W2023317081 hasConceptScore W2023317081C86803240 @default.
- W2023317081 hasConceptScore W2023317081C87644729 @default.
- W2023317081 hasConceptScore W2023317081C98274493 @default.
- W2023317081 hasIssue "12" @default.
- W2023317081 hasLocation W20233170811 @default.
- W2023317081 hasLocation W20233170812 @default.
- W2023317081 hasOpenAccess W2023317081 @default.
- W2023317081 hasPrimaryLocation W20233170811 @default.
- W2023317081 hasRelatedWork W1964883950 @default.
- W2023317081 hasRelatedWork W1979114098 @default.
- W2023317081 hasRelatedWork W1989204315 @default.
- W2023317081 hasRelatedWork W2006300374 @default.
- W2023317081 hasRelatedWork W2028842292 @default.
- W2023317081 hasRelatedWork W2131838860 @default.
- W2023317081 hasRelatedWork W2322389070 @default.
- W2023317081 hasRelatedWork W2395296658 @default.
- W2023317081 hasRelatedWork W2419447513 @default.
- W2023317081 hasRelatedWork W8334251 @default.
- W2023317081 hasVolume "9" @default.
- W2023317081 isParatext "false" @default.
- W2023317081 isRetracted "false" @default.
- W2023317081 magId "2023317081" @default.
- W2023317081 workType "article" @default.