FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023322512> ?p ?o ?g. }

• W2023322512 endingPage "34" @default.
• W2023322512 startingPage "28" @default.
• W2023322512 abstract "The acidic phospholipid requirement of the predominant particulate beta-glucosidase of mammalian spleen and liver was investigated using a series of N-acyl derivatives of dioleoyl phosphatidylethanolamine (PE). The PE, a neutral phospholipid, was converted to an acidic lipid, (N-acyl)-phosphatidylethanolamine (NAPE) by acylation of the amino group with different fatty acyl chains. Lysosomal beta-glucosidases from rat liver and spleens of controls and patients with various types of Gaucher's disease were solubilized and delipidated by extraction with sodium cholate and 1-butanol. All members of the NAPE series tested were effective activators of the delipidated rat liver beta-glucosidase, and the stimulatory power of the NAPE family increased with increasing chain length of the fatty acid substitution. In contrast, dioleoyl-PE had no effect on beta-glucosidase activity. A heat-stable factor (HSF) purified from the spleen of a patient with Gaucher's disease significantly increased the sensitivity of the rat liver beta-glucosidase to all of the NAPE derivatives. The maximum stimulation achieved in the presence of HSF was independent of N-acyl chain length. Compared to the potent activator, phosphatidylserine (PS), (N-acetyl)-PE and (N-linoleoyl)-PE were half as effective as activators of beta-glucosidase from control human spleen. PS stimulated the beta-glucosidase of type 1 nonneurologic Gaucher's disease, but none of the NAPE compounds activated it. Neither PS nor any of the (N-acyl)-PE compounds could activate a delipidated preparation of beta-glucosidase obtained from the spleen of a neurologic case. These results indicate that although the presence of a net negative charge on a phospholipid confers upon it an ability to reconstitute beta-glucosidase activity to the normal, nonmutant enzyme, it is insufficient to permit differentiation of the various types of Gaucher's disease." @default.
• W2023322512 created "2016-06-24" @default.
• W2023322512 creator A5051421325 @default.
• W2023322512 creator A5051498033 @default.
• W2023322512 creator A5077917198 @default.
• W2023322512 creator A5081785423 @default.
• W2023322512 creator A5083022460 @default.
• W2023322512 date "1985-11-01" @default.
• W2023322512 modified "2023-09-27" @default.
• W2023322512 title "Comparison of N-acyl phosphatidylethanolamines with different N-acyl groups as activators of glucocerebrosidase in various forms of Gaucher's disease" @default.
• W2023322512 cites W140531759 @default.
• W2023322512 cites W1511310156 @default.
• W2023322512 cites W1513897103 @default.
• W2023322512 cites W1529738243 @default.
• W2023322512 cites W1545175876 @default.
• W2023322512 cites W180208641 @default.
• W2023322512 cites W1968162959 @default.
• W2023322512 cites W1980356101 @default.
• W2023322512 cites W1997657368 @default.
• W2023322512 cites W2009615165 @default.
• W2023322512 cites W2013006360 @default.
• W2023322512 cites W2034843625 @default.
• W2023322512 cites W2037017555 @default.
• W2023322512 cites W2049043357 @default.
• W2023322512 cites W2056766188 @default.
• W2023322512 cites W2061053421 @default.
• W2023322512 cites W2082950211 @default.
• W2023322512 cites W2124663723 @default.
• W2023322512 cites W2137535114 @default.
• W2023322512 cites W2191601680 @default.
• W2023322512 cites W2408181277 @default.
• W2023322512 cites W2421761749 @default.
• W2023322512 cites W4293247451 @default.
• W2023322512 doi "https://doi.org/10.1016/0003-9861(85)90770-2" @default.
• W2023322512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3933429" @default.
• W2023322512 hasPublicationYear "1985" @default.
• W2023322512 type Work @default.
• W2023322512 sameAs 2023322512 @default.
• W2023322512 citedByCount "28" @default.
• W2023322512 countsByYear W20233225122015 @default.
• W2023322512 countsByYear W20233225122017 @default.
• W2023322512 countsByYear W20233225122020 @default.
• W2023322512 crossrefType "journal-article" @default.
• W2023322512 hasAuthorship W2023322512A5051421325 @default.
• W2023322512 hasAuthorship W2023322512A5051498033 @default.
• W2023322512 hasAuthorship W2023322512A5077917198 @default.
• W2023322512 hasAuthorship W2023322512A5081785423 @default.
• W2023322512 hasAuthorship W2023322512A5083022460 @default.
• W2023322512 hasConcept C126322002 @default.
• W2023322512 hasConcept C12927208 @default.
• W2023322512 hasConcept C161790260 @default.
• W2023322512 hasConcept C181199279 @default.
• W2023322512 hasConcept C185592680 @default.
• W2023322512 hasConcept C193557335 @default.
• W2023322512 hasConcept C2776330855 @default.
• W2023322512 hasConcept C2776551241 @default.
• W2023322512 hasConcept C2776723260 @default.
• W2023322512 hasConcept C2778530336 @default.
• W2023322512 hasConcept C2778918659 @default.
• W2023322512 hasConcept C2779134260 @default.
• W2023322512 hasConcept C2779637612 @default.
• W2023322512 hasConcept C2780674200 @default.
• W2023322512 hasConcept C2780931953 @default.
• W2023322512 hasConcept C2781170229 @default.
• W2023322512 hasConcept C41625074 @default.
• W2023322512 hasConcept C543025807 @default.
• W2023322512 hasConcept C55493867 @default.
• W2023322512 hasConcept C71924100 @default.
• W2023322512 hasConceptScore W2023322512C126322002 @default.
• W2023322512 hasConceptScore W2023322512C12927208 @default.
• W2023322512 hasConceptScore W2023322512C161790260 @default.
• W2023322512 hasConceptScore W2023322512C181199279 @default.
• W2023322512 hasConceptScore W2023322512C185592680 @default.
• W2023322512 hasConceptScore W2023322512C193557335 @default.
• W2023322512 hasConceptScore W2023322512C2776330855 @default.
• W2023322512 hasConceptScore W2023322512C2776551241 @default.
• W2023322512 hasConceptScore W2023322512C2776723260 @default.
• W2023322512 hasConceptScore W2023322512C2778530336 @default.
• W2023322512 hasConceptScore W2023322512C2778918659 @default.
• W2023322512 hasConceptScore W2023322512C2779134260 @default.
• W2023322512 hasConceptScore W2023322512C2779637612 @default.
• W2023322512 hasConceptScore W2023322512C2780674200 @default.
• W2023322512 hasConceptScore W2023322512C2780931953 @default.
• W2023322512 hasConceptScore W2023322512C2781170229 @default.
• W2023322512 hasConceptScore W2023322512C41625074 @default.
• W2023322512 hasConceptScore W2023322512C543025807 @default.
• W2023322512 hasConceptScore W2023322512C55493867 @default.
• W2023322512 hasConceptScore W2023322512C71924100 @default.
• W2023322512 hasIssue "1" @default.
• W2023322512 hasLocation W20233225121 @default.
• W2023322512 hasLocation W20233225122 @default.
• W2023322512 hasOpenAccess W2023322512 @default.
• W2023322512 hasPrimaryLocation W20233225121 @default.
• W2023322512 hasRelatedWork W1980929094 @default.
• W2023322512 hasRelatedWork W2023322512 @default.
• W2023322512 hasRelatedWork W2039550083 @default.
• W2023322512 hasRelatedWork W2048465125 @default.
• W2023322512 hasRelatedWork W2082730917 @default.

• next