FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023323071> ?p ?o ?g. }

• W2023323071 endingPage "859" @default.
• W2023323071 startingPage "850" @default.
• W2023323071 abstract "Vasodilation in normal and vasoconstriction in atherosclerotic coronary arteries have been observed in response to complex stimuli such as exercise and the cold pressor test. To study a single parameter that changes during these activities, and to better understand the pathophysiology of ischemia associated with increases in heart rate, we studied coronary vasomotion and blood flow response to increasing heart rate alone, produced by atrial pacing, with quantitative angiographic and Doppler flow-velocity measurements in 15 patients. In five patients with angiographically smooth coronary arteries (group 1), tachycardia produced progressive dilation of the epicardial artery with increases in cross-sectional area (CSA) of +15.5 +/- 3.4%, +22.4 +/- 2.1%, +28.5 +/- 3.3%, and +30.6 +/- 2.2% at 90, 110, 130, and 150 beats/min, respectively. In contrast, in five patients with mild angiographic narrowings (group 2), coronary segments failed to dilate with progressive tachycardia (-6.3 +/- 2.0%, -8.3 +/- 2.0%, -12.5 +/- 2.0%, and -11.4% at 90, 110, 130, and 150 beats/min, respectively), and progressive loss of luminal area was observed in five patients with severe angiographic narrowings (group 3) (-34.4 +/- 3.4%, -49.6 +/- 2.2%, -59.2%, and -72.8% at 90, 110, 130, and 150 beats/min, respectively). Coronary blood flow increased significantly with tachycardia in group 1 (+44.5 +/- 10.2%, +86.0 +/- 24.6%, +105.8 +/- 29.3%, and +137.5 +/- 46.0%), increased slightly in group 2 (+7.8 +/- 3.2%, +9.4 +/- 4.4%, +8.4 +/- 3.9%, and +10.0%), and decreased significantly in group 3 (-31.8 +/- 6%, -42.6 +/- 10.7%, -61.0%, and -70.0%). We conclude that an isolated increase in heart rate in patients with normal coronary arteries results in a modest increase in flow and vasodilation. In early atherosclerosis, the flow increase is blunted and dilation is replaced with paradoxical loss in luminal size. In patients with stenoses, further loss in luminal size occurs accompanied by a decrease in coronary blood flow. Thus, increasing heart rate alone in the setting of coronary stenoses could produce myocardial ischemia by a reduction in coronary supply, as well as by an increase in oxygen demand." @default.
• W2023323071 created "2016-06-24" @default.
• W2023323071 creator A5046279796 @default.
• W2023323071 creator A5067510658 @default.
• W2023323071 creator A5070980712 @default.
• W2023323071 date "1990-03-01" @default.
• W2023323071 modified "2023-09-27" @default.
• W2023323071 title "Paradoxical narrowing of atherosclerotic coronary arteries induced by increases in heart rate." @default.
• W2023323071 cites W1491076358 @default.
• W2023323071 cites W1968264611 @default.
• W2023323071 cites W1974983665 @default.
• W2023323071 cites W1980278241 @default.
• W2023323071 cites W1982520942 @default.
• W2023323071 cites W1983322810 @default.
• W2023323071 cites W1992749724 @default.
• W2023323071 cites W1993146946 @default.
• W2023323071 cites W1997301498 @default.
• W2023323071 cites W2003233163 @default.
• W2023323071 cites W2008790997 @default.
• W2023323071 cites W2015210790 @default.
• W2023323071 cites W2028612028 @default.
• W2023323071 cites W2040497473 @default.
• W2023323071 cites W2042569178 @default.
• W2023323071 cites W2058146763 @default.
• W2023323071 cites W2067483674 @default.
• W2023323071 cites W2077935074 @default.
• W2023323071 cites W2080686773 @default.
• W2023323071 cites W2081114784 @default.
• W2023323071 cites W2133458581 @default.
• W2023323071 cites W2139913774 @default.
• W2023323071 cites W2335161036 @default.
• W2023323071 cites W2410317274 @default.
• W2023323071 cites W4299696637 @default.
• W2023323071 doi "https://doi.org/10.1161/01.cir.81.3.850" @default.
• W2023323071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2306836" @default.
• W2023323071 hasPublicationYear "1990" @default.
• W2023323071 type Work @default.
• W2023323071 sameAs 2023323071 @default.
• W2023323071 citedByCount "170" @default.
• W2023323071 countsByYear W20233230712012 @default.
• W2023323071 countsByYear W20233230712013 @default.
• W2023323071 countsByYear W20233230712014 @default.
• W2023323071 countsByYear W20233230712015 @default.
• W2023323071 countsByYear W20233230712016 @default.
• W2023323071 countsByYear W20233230712017 @default.
• W2023323071 countsByYear W20233230712018 @default.
• W2023323071 countsByYear W20233230712020 @default.
• W2023323071 countsByYear W20233230712021 @default.
• W2023323071 crossrefType "journal-article" @default.
• W2023323071 hasAuthorship W2023323071A5046279796 @default.
• W2023323071 hasAuthorship W2023323071A5067510658 @default.
• W2023323071 hasAuthorship W2023323071A5070980712 @default.
• W2023323071 hasBestOaLocation W20233230711 @default.
• W2023323071 hasConcept C120770815 @default.
• W2023323071 hasConcept C126322002 @default.
• W2023323071 hasConcept C158846371 @default.
• W2023323071 hasConcept C164705383 @default.
• W2023323071 hasConcept C2776820930 @default.
• W2023323071 hasConcept C2777583614 @default.
• W2023323071 hasConcept C2777953023 @default.
• W2023323071 hasConcept C2778742706 @default.
• W2023323071 hasConcept C2779961880 @default.
• W2023323071 hasConcept C2780283014 @default.
• W2023323071 hasConcept C33971717 @default.
• W2023323071 hasConcept C71924100 @default.
• W2023323071 hasConcept C84393581 @default.
• W2023323071 hasConceptScore W2023323071C120770815 @default.
• W2023323071 hasConceptScore W2023323071C126322002 @default.
• W2023323071 hasConceptScore W2023323071C158846371 @default.
• W2023323071 hasConceptScore W2023323071C164705383 @default.
• W2023323071 hasConceptScore W2023323071C2776820930 @default.
• W2023323071 hasConceptScore W2023323071C2777583614 @default.
• W2023323071 hasConceptScore W2023323071C2777953023 @default.
• W2023323071 hasConceptScore W2023323071C2778742706 @default.
• W2023323071 hasConceptScore W2023323071C2779961880 @default.
• W2023323071 hasConceptScore W2023323071C2780283014 @default.
• W2023323071 hasConceptScore W2023323071C33971717 @default.
• W2023323071 hasConceptScore W2023323071C71924100 @default.
• W2023323071 hasConceptScore W2023323071C84393581 @default.
• W2023323071 hasIssue "3" @default.
• W2023323071 hasLocation W20233230711 @default.
• W2023323071 hasLocation W20233230712 @default.
• W2023323071 hasOpenAccess W2023323071 @default.
• W2023323071 hasPrimaryLocation W20233230711 @default.
• W2023323071 hasRelatedWork W160414271 @default.
• W2023323071 hasRelatedWork W162388635 @default.
• W2023323071 hasRelatedWork W1651088800 @default.
• W2023323071 hasRelatedWork W2060237981 @default.
• W2023323071 hasRelatedWork W2066605659 @default.
• W2023323071 hasRelatedWork W2071219253 @default.
• W2023323071 hasRelatedWork W2081869822 @default.
• W2023323071 hasRelatedWork W2139497529 @default.
• W2023323071 hasRelatedWork W3151601506 @default.
• W2023323071 hasRelatedWork W41933167 @default.
• W2023323071 hasVolume "81" @default.
• W2023323071 isParatext "false" @default.
• W2023323071 isRetracted "false" @default.
• W2023323071 magId "2023323071" @default.

• next