FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023325045> ?p ?o ?g. }

• W2023325045 endingPage "1438" @default.
• W2023325045 startingPage "1432" @default.
• W2023325045 abstract "Immunotherapy of tumors and of melanoma in particular has a long history, and recently this therapeutic approach found a reliable scientific rationale. This biological therapy aims to teach the patient's immune system to recognize the antigens expressed on tumor cells and destroy them, leaving normal cells intact. The success of this therapy highly depends on the selection of target antigens that are essential for tumors growth and progression. The overexpression of GM(3) ganglioside 1 and especially the expression of its metabolite GM(3) lactone 2 characterize murine and human melanomas, playing an important role in tumor progression and making such self-antigens potential targets for the immunotherapy of these neoplasms. Although more immunogenic than its precursor, GM(3) lactone 2 is unsuitable to be used in immunotherapy as a melanoma-associated antigen (MAA) because it is unstable under physiological conditions. We designed and synthesized the hydrolytically stable mimetic 3, which is remarkably simpler than the native lactone 2; after conjugation of 3 to the protein carrier keyhole-limpet hemocyanin (KLH), the obtained glycoprotein 5 was used as the immunogen in vivo to successfully elicit specific antimelanoma antibodies. In fact, no appreciable binding to GM(1) was observed. Capitalizing on the stability and on the reduced structural complexity of mimetic 3, the immunostimulant 5 we report represents a new promising synthetic glycoconjugate for the immunotherapy of melanoma." @default.
• W2023325045 created "2016-06-24" @default.
• W2023325045 creator A5000827403 @default.
• W2023325045 creator A5001669766 @default.
• W2023325045 creator A5029640604 @default.
• W2023325045 creator A5031979253 @default.
• W2023325045 creator A5038246078 @default.
• W2023325045 creator A5042612943 @default.
• W2023325045 creator A5045166586 @default.
• W2023325045 creator A5046278499 @default.
• W2023325045 creator A5062176432 @default.
• W2023325045 creator A5065503963 @default.
• W2023325045 date "2010-07-29" @default.
• W2023325045 modified "2023-10-16" @default.
• W2023325045 title "Stable GM₃ Lactone Mimetic Raises Antibodies Specific for the Antigens Expressed on Melanoma Cells" @default.
• W2023325045 cites W1040845057 @default.
• W2023325045 cites W1532637157 @default.
• W2023325045 cites W1979727645 @default.
• W2023325045 cites W1987702006 @default.
• W2023325045 cites W1991528365 @default.
• W2023325045 cites W1994202554 @default.
• W2023325045 cites W1997064007 @default.
• W2023325045 cites W2008083855 @default.
• W2023325045 cites W2009119064 @default.
• W2023325045 cites W2021647329 @default.
• W2023325045 cites W2022797612 @default.
• W2023325045 cites W2023271753 @default.
• W2023325045 cites W2026323819 @default.
• W2023325045 cites W2028781651 @default.
• W2023325045 cites W2029867653 @default.
• W2023325045 cites W2032942426 @default.
• W2023325045 cites W2038083805 @default.
• W2023325045 cites W2038270516 @default.
• W2023325045 cites W2039349277 @default.
• W2023325045 cites W2048729150 @default.
• W2023325045 cites W2054557523 @default.
• W2023325045 cites W2064988551 @default.
• W2023325045 cites W2072733441 @default.
• W2023325045 cites W2075224158 @default.
• W2023325045 cites W2080031306 @default.
• W2023325045 cites W2097935710 @default.
• W2023325045 cites W2107160157 @default.
• W2023325045 cites W2143981217 @default.
• W2023325045 cites W2148523692 @default.
• W2023325045 cites W2155488984 @default.
• W2023325045 cites W2161112061 @default.
• W2023325045 cites W2163867492 @default.
• W2023325045 cites W2951048900 @default.
• W2023325045 cites W2953322333 @default.
• W2023325045 cites W4246527033 @default.
• W2023325045 doi "https://doi.org/10.1021/bc900557v" @default.
• W2023325045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20669938" @default.
• W2023325045 hasPublicationYear "2010" @default.
• W2023325045 type Work @default.
• W2023325045 sameAs 2023325045 @default.
• W2023325045 citedByCount "25" @default.
• W2023325045 countsByYear W20233250452012 @default.
• W2023325045 countsByYear W20233250452013 @default.
• W2023325045 countsByYear W20233250452014 @default.
• W2023325045 countsByYear W20233250452015 @default.
• W2023325045 countsByYear W20233250452016 @default.
• W2023325045 countsByYear W20233250452017 @default.
• W2023325045 countsByYear W20233250452018 @default.
• W2023325045 countsByYear W20233250452020 @default.
• W2023325045 countsByYear W20233250452021 @default.
• W2023325045 countsByYear W20233250452022 @default.
• W2023325045 crossrefType "journal-article" @default.
• W2023325045 hasAuthorship W2023325045A5000827403 @default.
• W2023325045 hasAuthorship W2023325045A5001669766 @default.
• W2023325045 hasAuthorship W2023325045A5029640604 @default.
• W2023325045 hasAuthorship W2023325045A5031979253 @default.
• W2023325045 hasAuthorship W2023325045A5038246078 @default.
• W2023325045 hasAuthorship W2023325045A5042612943 @default.
• W2023325045 hasAuthorship W2023325045A5045166586 @default.
• W2023325045 hasAuthorship W2023325045A5046278499 @default.
• W2023325045 hasAuthorship W2023325045A5062176432 @default.
• W2023325045 hasAuthorship W2023325045A5065503963 @default.
• W2023325045 hasConcept C13426554 @default.
• W2023325045 hasConcept C147483822 @default.
• W2023325045 hasConcept C159654299 @default.
• W2023325045 hasConcept C185592680 @default.
• W2023325045 hasConcept C203014093 @default.
• W2023325045 hasConcept C2776727803 @default.
• W2023325045 hasConcept C2777658100 @default.
• W2023325045 hasConcept C2777701055 @default.
• W2023325045 hasConcept C2779909307 @default.
• W2023325045 hasConcept C2781264782 @default.
• W2023325045 hasConcept C502942594 @default.
• W2023325045 hasConcept C542903549 @default.
• W2023325045 hasConcept C55493867 @default.
• W2023325045 hasConcept C86803240 @default.
• W2023325045 hasConcept C8891405 @default.
• W2023325045 hasConceptScore W2023325045C13426554 @default.
• W2023325045 hasConceptScore W2023325045C147483822 @default.
• W2023325045 hasConceptScore W2023325045C159654299 @default.
• W2023325045 hasConceptScore W2023325045C185592680 @default.
• W2023325045 hasConceptScore W2023325045C203014093 @default.
• W2023325045 hasConceptScore W2023325045C2776727803 @default.

• next