FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023331375> ?p ?o ?g. }

• W2023331375 endingPage "17" @default.
• W2023331375 startingPage "9" @default.
• W2023331375 abstract "We aimed to investigate whether pretreatment serum levels of squamous cell carcinoma (SCC) antigen (SCC-Ag), cytokeratin 19 (CYFRA 21-1) and two mucins (CA 15-3 and CA 125) identify patients with occult disease in early-stage SCC of the cervix. Therefore, pretreatment serum samples were obtained from 78 patients with SCC of the cervix (52 IB, 9 IIA and 18 IIB), and tumor markers were measured with commercial immunoassays. SCC-Ag, CYFRA 21-1 and CA 15-3 (analyzed as continuous variables) were significantly associated with overall (OS) and disease-free survival (DFS) in univariate analysis (p < 0.001 in all cases). Multivariate analysis identified lymph node status as the strongest predictor for OS and DFS (p < 0.001 and p = 0.001, respectively), followed by CYFRA 21-1 (p = 0.060 and p = 0.027, respectively) and CA 15-3 (p = 0.082 and p = 0.017, respectively). Clinical cutoff values for each marker were defined by maximizing the log-rank statistics for OS in the total population: 1.1 microg/l for SCC-Ag (n = 47, 60.3%), 1.4 microg/l for CYFRA 21-1 (n = 47, 60.3%), 40 U/ml for CA 15-3 (n = 11, 14.1%) and 30 U/ml for CA 125 (n = 10, 12.8%). Stage IB patients with positive SCC-Ag and CYFRA 21-1 had significantly lower OS (mean 8.3 years, 95% confidence interval, CI, 5.8-10.7 years) and DFS (mean 7.3 years, 95% CI 4.6-10 years) than all other stage IB patients (OS, mean 14.5 years, 95% CI 13.5-15.5 years; DFS, mean 13.9 years, 95% CI 12.5-15.4 years). Stage IB patients with tumors <4 cm or with negative lymph nodes and positive SCC-Ag and CYFRA 21-1 had significantly poorer OS and DFS compared to all other patients in the same group. Elevated levels of both CA 125 and CA 15-3 (3 patients) were associated with an extremely poor prognosis. In conclusion, a combination of SCC-Ag and CYFRA 21-1 may help to identify early-stage cervical cancer patients with occult disease requiring adjuvant therapy." @default.
• W2023331375 created "2016-06-24" @default.
• W2023331375 creator A5046972129 @default.
• W2023331375 creator A5050978592 @default.
• W2023331375 creator A5051560890 @default.
• W2023331375 creator A5062035305 @default.
• W2023331375 creator A5077953812 @default.
• W2023331375 creator A5085154496 @default.
• W2023331375 date "2008-01-01" @default.
• W2023331375 modified "2023-09-25" @default.
• W2023331375 title "A Combination of Serum Tumor Markers Identifies High-Risk Patients with Early-Stage Squamous Cervical Cancer" @default.
• W2023331375 cites W131542910 @default.
• W2023331375 cites W1580788756 @default.
• W2023331375 cites W1955145617 @default.
• W2023331375 cites W1969829190 @default.
• W2023331375 cites W1970118836 @default.
• W2023331375 cites W1979300931 @default.
• W2023331375 cites W2009653214 @default.
• W2023331375 cites W2011904133 @default.
• W2023331375 cites W2013896394 @default.
• W2023331375 cites W2024113002 @default.
• W2023331375 cites W2044573147 @default.
• W2023331375 cites W2045169826 @default.
• W2023331375 cites W2045236160 @default.
• W2023331375 cites W2047618260 @default.
• W2023331375 cites W2066491842 @default.
• W2023331375 cites W2073660691 @default.
• W2023331375 cites W2074433861 @default.
• W2023331375 cites W2081472405 @default.
• W2023331375 cites W2084857638 @default.
• W2023331375 cites W2100223058 @default.
• W2023331375 cites W2103600217 @default.
• W2023331375 cites W2110165124 @default.
• W2023331375 cites W2117330663 @default.
• W2023331375 cites W2120405223 @default.
• W2023331375 cites W2133379335 @default.
• W2023331375 cites W2142719896 @default.
• W2023331375 cites W2154376591 @default.
• W2023331375 cites W2324392028 @default.
• W2023331375 cites W2413473559 @default.
• W2023331375 cites W2474564759 @default.
• W2023331375 doi "https://doi.org/10.1159/000132566" @default.
• W2023331375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18497544" @default.
• W2023331375 hasPublicationYear "2008" @default.
• W2023331375 type Work @default.
• W2023331375 sameAs 2023331375 @default.
• W2023331375 citedByCount "22" @default.
• W2023331375 countsByYear W20233313752012 @default.
• W2023331375 countsByYear W20233313752013 @default.
• W2023331375 countsByYear W20233313752015 @default.
• W2023331375 countsByYear W20233313752016 @default.
• W2023331375 countsByYear W20233313752017 @default.
• W2023331375 countsByYear W20233313752018 @default.
• W2023331375 countsByYear W20233313752020 @default.
• W2023331375 crossrefType "journal-article" @default.
• W2023331375 hasAuthorship W2023331375A5046972129 @default.
• W2023331375 hasAuthorship W2023331375A5050978592 @default.
• W2023331375 hasAuthorship W2023331375A5051560890 @default.
• W2023331375 hasAuthorship W2023331375A5062035305 @default.
• W2023331375 hasAuthorship W2023331375A5077953812 @default.
• W2023331375 hasAuthorship W2023331375A5085154496 @default.
• W2023331375 hasConcept C121608353 @default.
• W2023331375 hasConcept C126322002 @default.
• W2023331375 hasConcept C144301174 @default.
• W2023331375 hasConcept C146357865 @default.
• W2023331375 hasConcept C151730666 @default.
• W2023331375 hasConcept C2777740455 @default.
• W2023331375 hasConcept C2780849966 @default.
• W2023331375 hasConcept C2908647359 @default.
• W2023331375 hasConcept C38180746 @default.
• W2023331375 hasConcept C44249647 @default.
• W2023331375 hasConcept C71924100 @default.
• W2023331375 hasConcept C86803240 @default.
• W2023331375 hasConcept C90924648 @default.
• W2023331375 hasConcept C99454951 @default.
• W2023331375 hasConceptScore W2023331375C121608353 @default.
• W2023331375 hasConceptScore W2023331375C126322002 @default.
• W2023331375 hasConceptScore W2023331375C144301174 @default.
• W2023331375 hasConceptScore W2023331375C146357865 @default.
• W2023331375 hasConceptScore W2023331375C151730666 @default.
• W2023331375 hasConceptScore W2023331375C2777740455 @default.
• W2023331375 hasConceptScore W2023331375C2780849966 @default.
• W2023331375 hasConceptScore W2023331375C2908647359 @default.
• W2023331375 hasConceptScore W2023331375C38180746 @default.
• W2023331375 hasConceptScore W2023331375C44249647 @default.
• W2023331375 hasConceptScore W2023331375C71924100 @default.
• W2023331375 hasConceptScore W2023331375C86803240 @default.
• W2023331375 hasConceptScore W2023331375C90924648 @default.
• W2023331375 hasConceptScore W2023331375C99454951 @default.
• W2023331375 hasIssue "1" @default.
• W2023331375 hasLocation W20233313751 @default.
• W2023331375 hasLocation W20233313752 @default.
• W2023331375 hasOpenAccess W2023331375 @default.
• W2023331375 hasPrimaryLocation W20233313751 @default.
• W2023331375 hasRelatedWork W2024472469 @default.
• W2023331375 hasRelatedWork W2362981704 @default.
• W2023331375 hasRelatedWork W2367054191 @default.
• W2023331375 hasRelatedWork W2367617697 @default.

• next