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• W2023334548 startingPage "140" @default.
• W2023334548 abstract "Legionella pneumophila has become a model system to decipher the non-apoptotic functions of caspases and their role in immunity. In permissive cells, the L. pneumophila-containing vacuole evades endosomal traffic and is remodelled by the endoplasmic reticulum. Evasion of the endosomes is mediated by the Dot/Icm type IV secretion system. Upon L. pneumophila infection of genetically restrictive cells such as wild-type (WT) C57Bl/6J murine macrophages, flagellin is sensed by the NOD-like receptor Nlrc4 leading to caspase-1 activation by the inflammasome complex. Then, caspase-7 is activated downstream of the Nlrc4 inflammasome, promoting non-apoptotic functions such as L. pneumophila-containing phagosome maturation and bacterial degradation. Interestingly, caspase-3 is activated in permissive cells during early stages of infection. However, caspase-3 activation does not lead to apoptosis until late stages of infection because it is associated with potent Dot/Icm-mediated anti-apoptotic stimuli that render the infected cells resistant to external apoptotic inducers. Therefore, the role of caspase-1 and non-apoptotic functions of executioner caspases are temporally and spatially modulated during infection by L. pneumophila, which determine permissiveness to intracellular bacterial proliferation. This review will examine the novel activation pathways of caspases by L. pneumophila and discuss their role in genetic restriction and permissiveness to infection." @default.
• W2023334548 created "2016-06-24" @default.
• W2023334548 creator A5049799267 @default.
• W2023334548 date "2010-02-01" @default.
• W2023334548 modified "2023-09-26" @default.
• W2023334548 title "Modulation of caspases and their non-apoptotic functions by<i>Legionella pneumophila</i>" @default.
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• W2023334548 doi "https://doi.org/10.1111/j.1462-5822.2009.01401.x" @default.
• W2023334548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19863553" @default.
• W2023334548 hasPublicationYear "2010" @default.
• W2023334548 type Work @default.
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