FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023335735> ?p ?o ?g. }

• W2023335735 endingPage "553" @default.
• W2023335735 startingPage "547" @default.
• W2023335735 abstract "Formoterol and salmeterol are new long acting beta 2 adrenoceptor agonists. The maximum relaxant effect, potency and functional antagonism against carbachol induced contraction for salmeterol, formoterol and salbutamol have been compared in the guinea pig isolated trachea. In addition, the possibility of inducing a non-beta adrenoceptor mediated relaxation by salmeterol was studied.Concentration response experiments were conducted with isolated tracheal preparations (n = 4-6 in all experiments), precontracted by carbachol to cause either 40% (60 nmol/l), 80% (0.3 mumol/l) or 100% (3 mumol/l, supramaximal) of the maximum contraction. Each beta agonist was added cumulatively at each level of precontraction. Additional cumulative concentration response experiments were conducted for salmeterol alone at the highest level of precontraction, with and without beta blockade by sotalol (1 mmol/l). With the drug concentrations which produced the maximum response and the highest level of precontraction, the relaxation of formoterol (10 nmol/l) and salmeterol (1 mumol/l) was also compared non-cumulatively. Finally, with the corresponding drug concentrations and precontraction, the relaxant effect was compared for formoterol (10 nmol/l) in salmeterol relaxed airways with that of salmeterol (1 mumol/l) in formoterol relaxed airways.The increase in carbachol concentration from 60 nmol/l to 3 mumol/l induced a rightward shift in the mean (SE) concentration (log steps) causing 50% maximum relaxation for salmeterol (0.73 (0.17)), formoterol (0.85 (0.18)), and salbutamol (1.13 (0.11)). Significant differences in the maximum relaxant effect were shown at the highest level of precontraction only, with a remaining active tension of percentage precontraction of 27% (4%) for 1 mumol/l salbutamol and 35% (3%) for 10 nmol/l formoterol compared with 50% (2%) for 1 mumol/l salmeterol. The rank order of potency was: formoterol > salbutamol approximately salmeterol at all levels of precontraction (-log EC50: 9.32 (0.05) for formoterol, 7.82 (0.08) for salbutamol, and 7.50 (0.13) for salmeterol at 80% maximum precontraction). Beta blockade by sotalol (1 mmol/l) significantly inhibited the relaxation induced by salmeterol (1 mumol/l) (remaining active tension: 104% (1%) v 71% (11%) of precontraction) but not the relaxation induced by salmeterol (10 mumol/l) (remaining active tension: 75% (5%) v 71% (12%) of precontraction). In the non-cumulative experiments, formoterol displayed more relaxant effect than salmeterol (remaining active tension: 51% (6%) v 65% (6%) of precontraction). Finally, formoterol significantly relaxed salmeterol relaxed airways (relaxant effect: 22% (8%) of precontraction) whereas there was no significant response to salmeterol in formoterol relaxed airways (relaxant effect: 5% (12%) of precontraction).In the guinea pig isolated trachea, formoterol and salbutamol produce more relaxant effect than salmeterol, suggesting that salmeterol is a partial beta 2 agonist. Very high concentrations of salmeterol may induce non-beta adrenoceptor mediated relaxation. Formoterol is more potent than both salbutamol and salmeterol. There is no pronounced difference in the magnitude of antagonism against carbachol induced contractions between salmeterol, formoterol, and salbutamol." @default.
• W2023335735 created "2016-06-24" @default.
• W2023335735 creator A5006926267 @default.
• W2023335735 creator A5008262804 @default.
• W2023335735 creator A5038287882 @default.
• W2023335735 creator A5050749407 @default.
• W2023335735 creator A5059800289 @default.
• W2023335735 date "1993-05-01" @default.
• W2023335735 modified "2023-10-01" @default.
• W2023335735 title "Salmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism." @default.
• W2023335735 cites W1498136500 @default.
• W2023335735 cites W1856029611 @default.
• W2023335735 cites W1893356872 @default.
• W2023335735 cites W1971930449 @default.
• W2023335735 cites W1973685106 @default.
• W2023335735 cites W1991869405 @default.
• W2023335735 cites W2010430854 @default.
• W2023335735 cites W2014395382 @default.
• W2023335735 cites W2017067198 @default.
• W2023335735 cites W2022551713 @default.
• W2023335735 cites W2024274246 @default.
• W2023335735 cites W2033486605 @default.
• W2023335735 cites W2039246964 @default.
• W2023335735 cites W2060844945 @default.
• W2023335735 cites W2061259150 @default.
• W2023335735 cites W2064548705 @default.
• W2023335735 cites W2066235065 @default.
• W2023335735 cites W2080522706 @default.
• W2023335735 cites W2131436997 @default.
• W2023335735 cites W2264291695 @default.
• W2023335735 doi "https://doi.org/10.1136/thx.48.5.547" @default.
• W2023335735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/464514" @default.
• W2023335735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8100652" @default.
• W2023335735 hasPublicationYear "1993" @default.
• W2023335735 type Work @default.
• W2023335735 sameAs 2023335735 @default.
• W2023335735 citedByCount "114" @default.
• W2023335735 countsByYear W20233357352012 @default.
• W2023335735 countsByYear W20233357352013 @default.
• W2023335735 countsByYear W20233357352015 @default.
• W2023335735 countsByYear W20233357352016 @default.
• W2023335735 countsByYear W20233357352017 @default.
• W2023335735 countsByYear W20233357352018 @default.
• W2023335735 countsByYear W20233357352019 @default.
• W2023335735 countsByYear W20233357352020 @default.
• W2023335735 countsByYear W20233357352021 @default.
• W2023335735 countsByYear W20233357352023 @default.
• W2023335735 crossrefType "journal-article" @default.
• W2023335735 hasAuthorship W2023335735A5006926267 @default.
• W2023335735 hasAuthorship W2023335735A5008262804 @default.
• W2023335735 hasAuthorship W2023335735A5038287882 @default.
• W2023335735 hasAuthorship W2023335735A5050749407 @default.
• W2023335735 hasAuthorship W2023335735A5059800289 @default.
• W2023335735 hasBestOaLocation W20233357351 @default.
• W2023335735 hasConcept C126322002 @default.
• W2023335735 hasConcept C134018914 @default.
• W2023335735 hasConcept C170493617 @default.
• W2023335735 hasConcept C2776042228 @default.
• W2023335735 hasConcept C2776136866 @default.
• W2023335735 hasConcept C2776371117 @default.
• W2023335735 hasConcept C2776719499 @default.
• W2023335735 hasConcept C2776780178 @default.
• W2023335735 hasConcept C2777394947 @default.
• W2023335735 hasConcept C2778938600 @default.
• W2023335735 hasConcept C2778988552 @default.
• W2023335735 hasConcept C2779871671 @default.
• W2023335735 hasConcept C2909086917 @default.
• W2023335735 hasConcept C42219234 @default.
• W2023335735 hasConcept C46821324 @default.
• W2023335735 hasConcept C71924100 @default.
• W2023335735 hasConcept C75214554 @default.
• W2023335735 hasConcept C98274493 @default.
• W2023335735 hasConceptScore W2023335735C126322002 @default.
• W2023335735 hasConceptScore W2023335735C134018914 @default.
• W2023335735 hasConceptScore W2023335735C170493617 @default.
• W2023335735 hasConceptScore W2023335735C2776042228 @default.
• W2023335735 hasConceptScore W2023335735C2776136866 @default.
• W2023335735 hasConceptScore W2023335735C2776371117 @default.
• W2023335735 hasConceptScore W2023335735C2776719499 @default.
• W2023335735 hasConceptScore W2023335735C2776780178 @default.
• W2023335735 hasConceptScore W2023335735C2777394947 @default.
• W2023335735 hasConceptScore W2023335735C2778938600 @default.
• W2023335735 hasConceptScore W2023335735C2778988552 @default.
• W2023335735 hasConceptScore W2023335735C2779871671 @default.
• W2023335735 hasConceptScore W2023335735C2909086917 @default.
• W2023335735 hasConceptScore W2023335735C42219234 @default.
• W2023335735 hasConceptScore W2023335735C46821324 @default.
• W2023335735 hasConceptScore W2023335735C71924100 @default.
• W2023335735 hasConceptScore W2023335735C75214554 @default.
• W2023335735 hasConceptScore W2023335735C98274493 @default.
• W2023335735 hasIssue "5" @default.
• W2023335735 hasLocation W20233357351 @default.
• W2023335735 hasLocation W20233357352 @default.
• W2023335735 hasLocation W20233357353 @default.
• W2023335735 hasLocation W20233357354 @default.
• W2023335735 hasOpenAccess W2023335735 @default.
• W2023335735 hasPrimaryLocation W20233357351 @default.
• W2023335735 hasRelatedWork W1483316099 @default.

• next