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- W2023336819 abstract "The aim of this study was to investigate whether the increase in body temperature caused by intracerebroventricular (i.c.v.) injection of recombinant mouse CCL3/MIP1alpha [C-C (two adjacent conserved cysteines) ligand 3/macrophage inflammatory protein-1alpha] constitutes solely a hyperthermic response or a true integrated fever. Additionally, we examined the effects of systemic administration of different antipyretic drugs including the glucocorticoid dexamethasone, on cerebrospinal fluid (CSF) concentration of prostaglandin (PG) E2 and on febrile response induced by CCL3/MIP1alpha. I.c.v. administration of CCL3/MIP1alpha evokes an integrated fever accompanied by a reduction in tail skin temperature and an increase in PGE2 concentration in the CSF. Dexamethasone and indomethacin markedly reduced the fever and the elevation of CSF PGE2 concentration induced by lipopolysaccharide (LPS) whereas both response evoked by i.c.v. CCL3/MIP1alpha were insensitive to this steroid. Indomethacin only blocked the PGE2 increase in the CSF whereas ibuprofen and celecoxib each blocked the fever and the elevation of CSF PGE2. In this study, we have demonstrated for the first time that CCL3/MIP1alpha evokes an integrated febrile response accompanied by an increase of PGE2 levels in the CSF. These events are dissociated, especially in animals treated with indomethacin. If PGE2 does not participate in the febrile response evoked by CCL3/MIP1alpha, the inhibition of this response by celecoxib and ibuprofen indicates additional mechanisms to the well-known inhibition of COX enzymes by these drugs. Such mechanisms do not seem to depend on cytokine synthesis and subsequent COX-2 induction." @default.
- W2023336819 created "2016-06-24" @default.
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- W2023336819 date "2006-09-01" @default.
- W2023336819 modified "2023-10-07" @default.
- W2023336819 title "CCL3/Macrophage inflammatory protein-1α induces fever and increases prostaglandin E2 in cerebrospinal fluid of rats: Effect of antipyretic drugs" @default.
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- W2023336819 cites W1602681003 @default.
- W2023336819 cites W1652237838 @default.
- W2023336819 cites W1966839779 @default.
- W2023336819 cites W1974610512 @default.
- W2023336819 cites W1974955493 @default.
- W2023336819 cites W1976510740 @default.
- W2023336819 cites W1979778191 @default.
- W2023336819 cites W1980153282 @default.
- W2023336819 cites W1985799274 @default.
- W2023336819 cites W1986293573 @default.
- W2023336819 cites W1991743392 @default.
- W2023336819 cites W1997883335 @default.
- W2023336819 cites W1998232267 @default.
- W2023336819 cites W1998963802 @default.
- W2023336819 cites W2000702920 @default.
- W2023336819 cites W2002655113 @default.
- W2023336819 cites W2007555682 @default.
- W2023336819 cites W2010062465 @default.
- W2023336819 cites W2010694924 @default.
- W2023336819 cites W2024852719 @default.
- W2023336819 cites W2030033188 @default.
- W2023336819 cites W2037402251 @default.
- W2023336819 cites W2046458530 @default.
- W2023336819 cites W2049050629 @default.
- W2023336819 cites W2051257884 @default.
- W2023336819 cites W2052351422 @default.
- W2023336819 cites W2053177676 @default.
- W2023336819 cites W2053273805 @default.
- W2023336819 cites W2053400349 @default.
- W2023336819 cites W2054415514 @default.
- W2023336819 cites W2063194150 @default.
- W2023336819 cites W2067260907 @default.
- W2023336819 cites W2068322061 @default.
- W2023336819 cites W2071789358 @default.
- W2023336819 cites W2075847211 @default.
- W2023336819 cites W2078941129 @default.
- W2023336819 cites W2083029863 @default.
- W2023336819 cites W2085402104 @default.
- W2023336819 cites W2087631918 @default.
- W2023336819 cites W2088037140 @default.
- W2023336819 cites W2093450068 @default.
- W2023336819 cites W2095338378 @default.
- W2023336819 cites W2101052664 @default.
- W2023336819 cites W2103663251 @default.
- W2023336819 cites W2104057569 @default.
- W2023336819 cites W2105303099 @default.
- W2023336819 cites W2105372476 @default.
- W2023336819 cites W2105817935 @default.
- W2023336819 cites W2107801397 @default.
- W2023336819 cites W2109577352 @default.
- W2023336819 cites W2124755902 @default.
- W2023336819 cites W2128414599 @default.
- W2023336819 cites W2128427328 @default.
- W2023336819 cites W2129604495 @default.
- W2023336819 cites W2142059774 @default.
- W2023336819 cites W2146865766 @default.
- W2023336819 cites W2149737060 @default.
- W2023336819 cites W2150336097 @default.
- W2023336819 cites W2151665669 @default.
- W2023336819 cites W2156243671 @default.
- W2023336819 cites W2159162955 @default.
- W2023336819 cites W2159973565 @default.
- W2023336819 cites W2168263358 @default.
- W2023336819 cites W2170235320 @default.
- W2023336819 cites W2171756360 @default.
- W2023336819 cites W2179921079 @default.
- W2023336819 cites W2337737596 @default.
- W2023336819 cites W2394598000 @default.
- W2023336819 cites W2412207465 @default.
- W2023336819 doi "https://doi.org/10.1016/j.brainres.2006.06.026" @default.
- W2023336819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16836983" @default.
- W2023336819 hasPublicationYear "2006" @default.
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