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- W2023339148 abstract "Evaluation of: Muraro PA, Douek DC, Packer A et al.: Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med. 201(5), 805–816 (2005). This study sought to determine the basis for the long-term suppression of inflammation in multiple sclerosis (MS) patients who receive autologous hematopoietic stem cell transplantation (auto-HSCT). The authors studied seven subjects who were clinically diagnosed with MS and who demonstrated neurological progression during the year prior to the study. Extensive fluorescence-activated cell sorting analysis for phenotype, as well as spectratyping and clonotyping of T cells, were performed in order to examine the size, composition and diversity of the T-cell pool throughout a 2-year post-transplantation period. They found that the suppression of inflammation in the brain, confirmed by magnetic resonance imaging studies, was not due to persistent lymphopenia, but rather due to the de novo regeneration of T cells. Despite the rejuvenation of a diverse T-cell repertoire in these patients, there was no significant improvement in terms of disability as scored by the expanded disability status score. This suggests that, in order for auto-HSCT to be beneficial in treating MS, the procedure must be performed early in the course of MS, when inflammation is abundant but neurodegeneration is limited." @default.
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- W2023339148 date "2006-07-01" @default.
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- W2023339148 title "Autologous hematopoietic stem cell transplantation: a cure for multiple sclerosis?" @default.
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- W2023339148 doi "https://doi.org/10.2217/14796708.1.4.403" @default.
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