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- W2023340103 abstract "ABSTRACT We are currently developing a monochromatic x-ray source for small animal tomographic imaging. This source consists of a conventional cone beam microfocus x-ray tube with a t ungsten target coupled to a filter that uses Bragg diffraction to transmit only x-rays within a narrow energy range (~3 keV FWHM). A tissue-equivalent mouse phantom was used to a) evaluate how clearly CT imaging using the quasi-monoenergetic beam is able to differentiate tissue types compared to conventional polyenergetic CT, and b) to test the ability of the source and Bragg filter combination to perform dual energy, iodine contrast enhanced imaging. Single slice CT scans of the phantom were obtained both with polyenergetic (1.8 mm Al filtration) and quasi-monoenergetic beams. Region of interest analysis showed that pixel value variance was signifcantly reduced in the quasi-monochromatic case compared to the polyenergetic case, suggesting a reduction in the variance of the linear attenuation coefficients of the tissue equivalent materials due to the narrower energy spectrum. To test dual energy iodine K-edge imaging, vials containing solutions with a range of iodine contrasts were added to the phantom. Single-slice CT scans were obtained using spectra with maximum values at 30 and 35 keV, respectively. Analysis of the resulting difference images (35 keV image 30 keV image) shows that the magnitude of the difference signal produced by iodine exceeds that of bone for iodine concentrations above ~20 mg/ml, and that of muscle and fat tissues for iodine concentrations above ~5 mg/ml. Keywords: CT, dual energy CT, Bragg filtration, quasi-monoenergetic x-ray imaging, iodine K-edge imaging" @default.
- W2023340103 created "2016-06-24" @default.
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- W2023340103 date "2008-03-06" @default.
- W2023340103 modified "2023-09-26" @default.
- W2023340103 title "Contrast imaging with a monochromatic x-ray scanner" @default.
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- W2023340103 doi "https://doi.org/10.1117/12.773127" @default.
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