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- W2023340322 abstract "Splicing of neural-specific exons is differentially regulated in neuronal and non-neuronal cells. The polypyrimidine tract binding protein (PTB) has been implicated as a negative regulator for exon splicing, whereas the brain-specific homolog of PTB, termed nPTB, promotes exon splicing exclusively in neurons. We have now isolated a novel mRNA splice variant of nPTB from non-neuronal cells. In contrast to the neural nPTB transcript, the expression of this novel isoform was absent from brain tissue and was generated in non-neuronal cells by alternative splicing to include five additional amino acid residues encoded by exon 9. In addition, we identified a brain-specific transcript containing a novel, alternatively spliced, internal exon 10. The exclusion of this 34-nucleotide exon 10 in non-neuronal tissues generates a premature termination codon and results in the truncation of the open reading frame. Our findings suggest that alternative splicing of nPTB has an important role in regulation of tissue-specific gene expression and thus in the functional activity of nPTB in neuronal and non-neuronal cells." @default.
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- W2023340322 date "2002-09-01" @default.
- W2023340322 modified "2023-09-25" @default.
- W2023340322 title "Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles" @default.
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- W2023340322 doi "https://doi.org/10.1006/geno.2002.6826" @default.
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