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• W2023341745 abstract "Bioassay-guided fractionation of an active methyl ethyl ketone extract of Edgeworthia gardneri, using an assay to monitor DNA polymerase beta lyase inhibition, resulted in the isolation of three known biscoumarin derivatives, 7-hydroxy-3,7'-dicoumaryl ether (edgeworin, 1), 7-hydroxy-6-methoxy-3,7'-dicoumaryl ether (daphnoretin, 2), and 6,7-dihydroxy-3,7'-dicoumaryl ether (edgeworthin, 3). Compounds 1-3 inhibited the lyase activity of DNA polymerase beta with IC(50) values of 7.3 microg/mL (22.5 microM), 43.0 microg/mL (122.3 microM), and 32.1 microg/mL (94.8 microM), respectively." @default.
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• W2023341745 date "2004-08-12" @default.
• W2023341745 modified "2023-09-22" @default.
• W2023341745 title "Biscoumarin Derivatives from <i>Edgeworthia </i><i>g</i><i>ardneri</i> that Inhibit the Lyase Activity of DNA Polymerase β" @default.
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• W2023341745 doi "https://doi.org/10.1021/np040127s" @default.
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