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• W2023341866 startingPage "60" @default.
• W2023341866 abstract "The desert gerbil, Psammomys obesus, is a unique polygenic animal model of metabolic syndrome (insulin resistance, obesity and type 2 diabetes), and these pathological conditions resemble to those in human beings. In this study, the animals were fed ad libitum either a natural diet (ND) which contained desertic halophile plants or a standard laboratory diet (STD) or a diet which contained eicosapentaenoic acid (EPA), hence, termed as EPA diet (EPAD). In EPAD, 50% of total lipid content was replaced by EPA oil. By employing real-time PCR, we assessed liver expression of key genes involved in fatty acid metabolism such as PPAR-α, SREBP-1c, LXR-α and CHREBP. We also studied the expression of two inflammatory genes, i.e., TNF-α and IL-1β, in liver and adipose tissue of these animals. The STD, considered to be a high caloric diet for this animal, triggered insulin resistance and high lipid levels, along with high hepatic SREBP-1c, LXR-α and CHREBP mRNA expression. TNF-α and IL-1β mRNA were also high in liver of STD fed animals. Feeding EPAD improved plasma glucose, insulin and triacylglycerol levels along with hepatic lipid composition. These observations suggest that EPA exerts beneficial effects in P. obesus." @default.
• W2023341866 created "2016-06-24" @default.
• W2023341866 creator A5015584836 @default.
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• W2023341866 creator A5087183337 @default.
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• W2023341866 date "2015-02-01" @default.
• W2023341866 modified "2023-09-25" @default.
• W2023341866 title "Eicosapentaenoic acid modulates fatty acid metabolism and inflammation in Psammomys obesus" @default.
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• W2023341866 doi "https://doi.org/10.1016/j.biochi.2014.12.004" @default.
• W2023341866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25528298" @default.
• W2023341866 hasPublicationYear "2015" @default.
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