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• W2023342093 startingPage "651" @default.
• W2023342093 abstract "Opioid peptides are synthesized in the form of large precursors, which contain the information for more than one biologically active peptide. Using recombinant DNA technology, three opioid precursors have been sequenced: pro-opiomelanocortin (POMC), proenkephalin and prodynorphin. Analysis of the structures of these three precursors and their corresponding genes show striking similarities suggesting a common evolutionary mechanism. Regulation of POMC gene expression has been analyzed in different rat tissues. Detection of POMC mRNA in brain tissues supports the hypothesis that ACTH and endorphin peptides are synthesized in these tissues. Quantitation of POMC mRNA levels in pituitaries of rats subjected to adrenalectomy and glucocorticoid treatment shows that the feedback effect of the glucocorticoids occurs at the level of the rate of transcription of POMC mRNA." @default.
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• W2023342093 date "1983-09-01" @default.
• W2023342093 modified "2023-09-27" @default.
• W2023342093 title "Regulation of opioid gene expression" @default.
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• W2023342093 doi "https://doi.org/10.1016/0196-9781(83)90013-x" @default.
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