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• W2023343652 endingPage "255" @default.
• W2023343652 startingPage "249" @default.
• W2023343652 abstract "Exposure to self-administered drugs is sufficient to produce drug-seeking in animal models. In many cases priming injections of drugs that share discriminative stimulus properties with the self-administered drug also can lead to drug-seeking, suggesting that exposure might precipitate relapse. The present investigation examined the ability of MDMA or cocaine priming injections to reinstate extinguished drug-seeking in rats. Priming injections of cocaine (0–20.0 mg/kg) and MDMA (0.0–10.0 mg/kg) reinstated extinguished drug-taking for both the cocaine- and MDMA-trained rats. In a separate group of cocaine-trained rats that received repeated exposure to 10.0 mg/kg MDMA, the initial exposure to MDMA (10.0 mg/kg, IP) failed to reinstate extinguished responding but MDMA became an effective prime for reinstatement of extinguished cocaine-taking behavior with repeated exposure. Effects of MDMA in MDMA-trained rats was greater than the effect in cocaine-trained rats suggesting that extensive experience with MDMA self-administration might have sensitized rats to this effect. These findings show that extinguished MDMA self-administration, like self-administration of other drugs of abuse, can be reinstated by exposure to psychostimulants thereby precipitating relapse." @default.
• W2023343652 created "2016-06-24" @default.
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• W2023343652 date "2008-08-01" @default.
• W2023343652 modified "2023-10-14" @default.
• W2023343652 title "Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats" @default.
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• W2023343652 doi "https://doi.org/10.1016/j.drugalcdep.2008.03.014" @default.
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• W2023343652 hasPublicationYear "2008" @default.
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