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- W2023343805 abstract "Magnetic particle imaging (MPI) using the nonlinear interaction between internally administered magnetic nanoparticles (MNPs) and electromagnetic waves irradiated from outside of the body has attracted attention for the early diagnosis of diseases such as cancer. In MPI, the local magnetic field distribution is scanned, and the magnetization signal from MNPs inside an object region is detected. However, the signal sensitivity and image resolution are degraded by interference from the magnetization signal generated by MNPs that exist outside of the desired region, owing to nonlinear responses. Earlier, we proposed an image reconstruction method for suppressing the interference component while emphasizing the signal component using the property of the higher harmonic components generated by the MNPs. However, edge areas in the reconstructed image were emphasized excessively owing to the high-pass-filter effect of this method. Here, we propose a new method based on correlation information between the observed signal and a system function. We performed a numerical analysis and found that, although the image was somewhat blurred, the detection sensitivity can clearly be improved without the inverse-matrix operation used in conventional image reconstruction." @default.
- W2023343805 created "2016-06-24" @default.
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- W2023343805 date "2011-03-03" @default.
- W2023343805 modified "2023-09-26" @default.
- W2023343805 title "Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles" @default.
- W2023343805 doi "https://doi.org/10.1117/12.878127" @default.
- W2023343805 hasPublicationYear "2011" @default.
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