FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023343815> ?p ?o ?g. }

• W2023343815 endingPage "86" @default.
• W2023343815 startingPage "79" @default.
• W2023343815 abstract "The evidence from pre-licensure studies does not suggest that there are clinically important differences in reactogenicity between acellular vaccines. The merits of different acellular products will therefore have to be compared on efficacy criteria. Ideally, acellular vaccines with the minimum antigen content necessary to ensure optimum protection should be used in order to avoid administration of superfluous antigens to children and to simplify licensing and batch release procedures. On the basis of the evidence so far available it seems unlikely that monocomponent pertussis toxin (PT) vaccines provide optimal protection and that multicomponent vaccines are needed to achieve a level of disease control that approaches that of a good whole-cell vaccine. It is unclear whether all two component vaccines containing PT and filamentous haemagglutinin (FHA) have similar efficacy but on the available evidence the safest option for policy makers would seem to be to use a vaccine with at least three components, PT+FHA+pertactin. There is now good evidence that the five component vaccine which contains agglutinogens 2 and 3 in addition to PT/FHA and pertactin provides the best protection and is the only acellular vaccine whose efficacy matches that of a good whole cell vaccine. However, the public health advantage of the five component vaccine over other acellular vaccines may not become apparent until they have been in routine use for some decades and their ability to protect against transmission as well as clinical pertussis has emerged. The decision to replace an effective whole-cell vaccine by an acellular vaccine for primary immunisation needs careful consideration. Apart from the probable sacrifice of efficacy for reduced reactogenicity (at least for vaccines which do not contain agglutinogens 2 and 3) there is the question of value for money and the ease with which acellular DTP vaccines can be combined with conjugate polysaccharide vaccines such as Haemophilus influenzae type b. Whatever the decision of policy makers, the need for continued follow up of trial cohorts and active surveillance of the efficacy and safety of those acellular vaccines that are introduced into routine use must be accorded a high priority." @default.
• W2023343815 created "2016-06-24" @default.
• W2023343815 creator A5054039682 @default.
• W2023343815 date "1999-06-01" @default.
• W2023343815 modified "2023-10-16" @default.
• W2023343815 title "Overview of Recent Clinical Trials of Acellular Pertussis Vaccines" @default.
• W2023343815 cites W1885686802 @default.
• W2023343815 cites W2009997530 @default.
• W2023343815 cites W2017954611 @default.
• W2023343815 cites W2023955193 @default.
• W2023343815 cites W2028774083 @default.
• W2023343815 cites W2029086429 @default.
• W2023343815 cites W2038028748 @default.
• W2023343815 cites W2078973665 @default.
• W2023343815 cites W2085498683 @default.
• W2023343815 cites W2095205137 @default.
• W2023343815 cites W2099620118 @default.
• W2023343815 cites W2106670406 @default.
• W2023343815 cites W2126536429 @default.
• W2023343815 cites W2140698201 @default.
• W2023343815 cites W2156075936 @default.
• W2023343815 cites W2321584961 @default.
• W2023343815 cites W2328100509 @default.
• W2023343815 cites W2340710149 @default.
• W2023343815 cites W3147976275 @default.
• W2023343815 doi "https://doi.org/10.1006/biol.1999.0184" @default.
• W2023343815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10600188" @default.
• W2023343815 hasPublicationYear "1999" @default.
• W2023343815 type Work @default.
• W2023343815 sameAs 2023343815 @default.
• W2023343815 citedByCount "54" @default.
• W2023343815 countsByYear W20233438152012 @default.
• W2023343815 countsByYear W20233438152013 @default.
• W2023343815 countsByYear W20233438152014 @default.
• W2023343815 countsByYear W20233438152017 @default.
• W2023343815 countsByYear W20233438152018 @default.
• W2023343815 countsByYear W20233438152019 @default.
• W2023343815 countsByYear W20233438152020 @default.
• W2023343815 countsByYear W20233438152021 @default.
• W2023343815 countsByYear W20233438152022 @default.
• W2023343815 countsByYear W20233438152023 @default.
• W2023343815 crossrefType "journal-article" @default.
• W2023343815 hasAuthorship W2023343815A5054039682 @default.
• W2023343815 hasConcept C126322002 @default.
• W2023343815 hasConcept C147483822 @default.
• W2023343815 hasConcept C159047783 @default.
• W2023343815 hasConcept C159110408 @default.
• W2023343815 hasConcept C170493617 @default.
• W2023343815 hasConcept C196419574 @default.
• W2023343815 hasConcept C203014093 @default.
• W2023343815 hasConcept C22070199 @default.
• W2023343815 hasConcept C2777704310 @default.
• W2023343815 hasConcept C2780441014 @default.
• W2023343815 hasConcept C2780801004 @default.
• W2023343815 hasConcept C2781234862 @default.
• W2023343815 hasConcept C49773422 @default.
• W2023343815 hasConcept C71924100 @default.
• W2023343815 hasConcept C80631254 @default.
• W2023343815 hasConceptScore W2023343815C126322002 @default.
• W2023343815 hasConceptScore W2023343815C147483822 @default.
• W2023343815 hasConceptScore W2023343815C159047783 @default.
• W2023343815 hasConceptScore W2023343815C159110408 @default.
• W2023343815 hasConceptScore W2023343815C170493617 @default.
• W2023343815 hasConceptScore W2023343815C196419574 @default.
• W2023343815 hasConceptScore W2023343815C203014093 @default.
• W2023343815 hasConceptScore W2023343815C22070199 @default.
• W2023343815 hasConceptScore W2023343815C2777704310 @default.
• W2023343815 hasConceptScore W2023343815C2780441014 @default.
• W2023343815 hasConceptScore W2023343815C2780801004 @default.
• W2023343815 hasConceptScore W2023343815C2781234862 @default.
• W2023343815 hasConceptScore W2023343815C49773422 @default.
• W2023343815 hasConceptScore W2023343815C71924100 @default.
• W2023343815 hasConceptScore W2023343815C80631254 @default.
• W2023343815 hasIssue "2" @default.
• W2023343815 hasLocation W20233438151 @default.
• W2023343815 hasLocation W20233438152 @default.
• W2023343815 hasOpenAccess W2023343815 @default.
• W2023343815 hasPrimaryLocation W20233438151 @default.
• W2023343815 hasRelatedWork W1537249735 @default.
• W2023343815 hasRelatedWork W1977940405 @default.
• W2023343815 hasRelatedWork W2000732603 @default.
• W2023343815 hasRelatedWork W2023288749 @default.
• W2023343815 hasRelatedWork W2038028748 @default.
• W2023343815 hasRelatedWork W2059577073 @default.
• W2023343815 hasRelatedWork W2062935972 @default.
• W2023343815 hasRelatedWork W2901445164 @default.
• W2023343815 hasRelatedWork W3137089541 @default.
• W2023343815 hasRelatedWork W215710792 @default.
• W2023343815 hasVolume "27" @default.
• W2023343815 isParatext "false" @default.
• W2023343815 isRetracted "false" @default.
• W2023343815 magId "2023343815" @default.
• W2023343815 workType "article" @default.