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- W2023343850 abstract "The translational regulation of maternal mRNAs is one of the most important steps in the control of temporal–spatial gene expression during oocyte maturation and early embryogenesis in various species. Recently, it has become clear that protein components of mRNPs play essential roles in the translational regulation of maternal mRNAs. In the present study, we investigated the function of P100 in Xenopus oocytes. P100 exhibits sequence conservation with budding yeast Pat1 and is likely the orthologue of human Pat1a (also called PatL2). P100 is maternally expressed in immature oocytes, but disappears during oocyte maturation. In oocytes, P100 is an RNA binding component of ribosome-free mRNPs, associating with other mRNP components such as Xp54, xRAP55 and CPEB. Translational repression by overexpression of P100 occurred when reporter mRNAs were injected into oocytes. Intriguingly, we found that when P100 was overexpressed in the oocytes, the kinetics of oocyte maturation was considerably retarded. In addition, overexpression of P100 in oocytes significantly affected the accumulation of c-Mos and cyclin B1 during oocyte maturation. These results suggest that P100 plays a role in regulating the translation of specific maternal mRNAs required for the progression of Xenopus oocyte maturation." @default.
- W2023343850 created "2016-06-24" @default.
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- W2023343850 date "2010-08-01" @default.
- W2023343850 modified "2023-09-27" @default.
- W2023343850 title "Translational repression by the oocyte-specific protein P100 in Xenopus" @default.
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- W2023343850 cites W1973050238 @default.
- W2023343850 cites W1973814530 @default.
- W2023343850 cites W1976527580 @default.
- W2023343850 cites W1980084095 @default.
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- W2023343850 cites W1990862736 @default.
- W2023343850 cites W1992686084 @default.
- W2023343850 cites W1994314126 @default.
- W2023343850 cites W1999950622 @default.
- W2023343850 cites W2002213903 @default.
- W2023343850 cites W2005869440 @default.
- W2023343850 cites W2007085897 @default.
- W2023343850 cites W2009050803 @default.
- W2023343850 cites W2011087509 @default.
- W2023343850 cites W2011262627 @default.
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- W2023343850 cites W2078055918 @default.
- W2023343850 cites W2078271694 @default.
- W2023343850 cites W2081670408 @default.
- W2023343850 cites W2082995067 @default.
- W2023343850 cites W2084286996 @default.
- W2023343850 cites W2089426978 @default.
- W2023343850 cites W2091759633 @default.
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- W2023343850 cites W2093205464 @default.
- W2023343850 cites W2093428569 @default.
- W2023343850 cites W2096469776 @default.
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- W2023343850 cites W2132397441 @default.
- W2023343850 cites W2132501533 @default.
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- W2023343850 cites W2140564918 @default.
- W2023343850 cites W2141325721 @default.
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- W2023343850 doi "https://doi.org/10.1016/j.ydbio.2010.05.006" @default.
- W2023343850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20471969" @default.
- W2023343850 hasPublicationYear "2010" @default.
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