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• W2023343969 abstract "<b>Background:</b> Leptin regulates appetite through the long isoform of its receptor in the hypothalamus. Although leptin regulates immune responses, it is still unknown whether a direct effect of leptin on lymphocytes is required. <b>Aims:</b> To clarify whether expression of leptin receptors on T lymphocytes modulates intestinal inflammation in mice. <b>Methods:</b> The model of colitis induced by transfer of CD4⁺CD45RB^high (RB^high) cells into <i>scid</i> mice was used. Wild-type (WT) or leptin receptor deficient (<i>db/db</i>) RB^high cells were transferred into <i>scid</i> mice and development of colitis evaluated. <b>Results:</b> Leptin receptors were expressed on both RB^high and RB^low cells. Intestinal lymphocytes of mice with colitis expressed high leptin levels compared with healthy controls whereas the opposite was true for serum leptin levels. Transfer of RB^high cells from <i>db/db</i> mice induced delayed disease compared with transfer of WT cells. A high rate of apoptosis in lamina propria lymphocytes and reduced cytokine production were observed early on in <i>scid</i> mice receiving <i>db/db</i> RB^high cells. These effects were not due to the high levels of glucocorticoids present in <i>db/db</i> mice as administration of corticosterone to WT mice failed to reproduce this phenomenon. High expression of peroxisome proliferator activated receptor γ was observed in the colon of recipients of <i>db/db</i> compared with WT cells. Freshly isolated <i>db/db</i> RB^high cells produced low levels of interferon γ. Despite delayed onset of colitis, as disease progressed differences between mice receiving WT or <i>db/db</i> cells were no longer apparent. <b>Conclusions:</b> These results suggest that leptin affects the immune response, partly by acting on the long isoform of its receptor expressed on T lymphocytes." @default.
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• W2023343969 date "2004-07-01" @default.
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• W2023343969 title "Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice" @default.
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• W2023343969 doi "https://doi.org/10.1136/gut.2003.027136" @default.
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