FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023344075> ?p ?o ?g. }

• W2023344075 endingPage "1619" @default.
• W2023344075 startingPage "1608" @default.
• W2023344075 abstract "The p53 tumor suppressor is a tetrameric transcriptional enhancer, and its activity is compromised by mutations that cause amino acid substitutions in its tetramerization domain. Here we analyze the biochemical and biophysical properties of peptides corresponding to amino acids 319−358 of wild-type human p53, which includes the tetramerization domain, and that of a cancer-derived mutant with valine substituted for glycine 334. Unlike the wild-type peptide, the G334V peptide forms amyloid fibrils by a two-step process under physiological conditions of temperature and pH. Nevertheless, the G334V peptide is capable of forming heterooligomers with a wild-type peptide. Computational modeling of the G334V peptide structure suggests that substitution of valine for glycine 334 causes a local distortion that contributes to a β-dominated structural transition leading to amyloid formation. Since the distortion is mostly on the surface, the mutant peptide is still able to form a pseudonative tetramer complex at higher concentrations and/or lower temperatures. Our study suggests a new potential mechanism by which mutations that compromise tetramer formation inactivate p53 as a tumor suppressor." @default.
• W2023344075 created "2016-06-24" @default.
• W2023344075 creator A5007171355 @default.
• W2023344075 creator A5015581163 @default.
• W2023344075 creator A5022226465 @default.
• W2023344075 creator A5025165307 @default.
• W2023344075 creator A5039558836 @default.
• W2023344075 creator A5051370653 @default.
• W2023344075 creator A5056113215 @default.
• W2023344075 creator A5083401692 @default.
• W2023344075 creator A5087453048 @default.
• W2023344075 date "2006-01-24" @default.
• W2023344075 modified "2023-10-02" @default.
• W2023344075 title "Unfolding, Aggregation, and Amyloid Formation by the Tetramerization Domain from Mutant p53 Associated with Lung Cancer" @default.
• W2023344075 cites W1563988826 @default.
• W2023344075 cites W1888259200 @default.
• W2023344075 cites W1967733770 @default.
• W2023344075 cites W1968280815 @default.
• W2023344075 cites W1969261030 @default.
• W2023344075 cites W1972535964 @default.
• W2023344075 cites W1973897761 @default.
• W2023344075 cites W1974187431 @default.
• W2023344075 cites W1976078149 @default.
• W2023344075 cites W1978960142 @default.
• W2023344075 cites W1979509752 @default.
• W2023344075 cites W1982033147 @default.
• W2023344075 cites W1984166452 @default.
• W2023344075 cites W1991494214 @default.
• W2023344075 cites W1996899753 @default.
• W2023344075 cites W2004593644 @default.
• W2023344075 cites W2005986251 @default.
• W2023344075 cites W2009745999 @default.
• W2023344075 cites W2018769240 @default.
• W2023344075 cites W2027408247 @default.
• W2023344075 cites W2030693141 @default.
• W2023344075 cites W2037954483 @default.
• W2023344075 cites W2042316019 @default.
• W2023344075 cites W2047004797 @default.
• W2023344075 cites W2049695588 @default.
• W2023344075 cites W2054177557 @default.
• W2023344075 cites W2056816046 @default.
• W2023344075 cites W2057203887 @default.
• W2023344075 cites W2057289558 @default.
• W2023344075 cites W2059960292 @default.
• W2023344075 cites W2063669247 @default.
• W2023344075 cites W2064850058 @default.
• W2023344075 cites W2066154992 @default.
• W2023344075 cites W2068048784 @default.
• W2023344075 cites W2069233533 @default.
• W2023344075 cites W2069900557 @default.
• W2023344075 cites W2073576377 @default.
• W2023344075 cites W2074986801 @default.
• W2023344075 cites W2076156268 @default.
• W2023344075 cites W2077000240 @default.
• W2023344075 cites W2087908369 @default.
• W2023344075 cites W2088172210 @default.
• W2023344075 cites W2093059615 @default.
• W2023344075 cites W2097337402 @default.
• W2023344075 cites W2099092270 @default.
• W2023344075 cites W2110863368 @default.
• W2023344075 cites W2120717592 @default.
• W2023344075 cites W2120961400 @default.
• W2023344075 cites W2130479394 @default.
• W2023344075 cites W2131718952 @default.
• W2023344075 cites W2134661315 @default.
• W2023344075 cites W2135911067 @default.
• W2023344075 cites W2142476286 @default.
• W2023344075 cites W2152278845 @default.
• W2023344075 cites W2152292155 @default.
• W2023344075 cites W2153439292 @default.
• W2023344075 cites W2154721456 @default.
• W2023344075 cites W2162166182 @default.
• W2023344075 cites W2405821997 @default.
• W2023344075 cites W2416711677 @default.
• W2023344075 doi "https://doi.org/10.1021/bi051192j" @default.
• W2023344075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2536691" @default.
• W2023344075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16460008" @default.
• W2023344075 hasPublicationYear "2006" @default.
• W2023344075 type Work @default.
• W2023344075 sameAs 2023344075 @default.
• W2023344075 citedByCount "65" @default.
• W2023344075 countsByYear W20233440752012 @default.
• W2023344075 countsByYear W20233440752013 @default.
• W2023344075 countsByYear W20233440752014 @default.
• W2023344075 countsByYear W20233440752015 @default.
• W2023344075 countsByYear W20233440752016 @default.
• W2023344075 countsByYear W20233440752017 @default.
• W2023344075 countsByYear W20233440752018 @default.
• W2023344075 countsByYear W20233440752019 @default.
• W2023344075 countsByYear W20233440752020 @default.
• W2023344075 countsByYear W20233440752021 @default.
• W2023344075 countsByYear W20233440752022 @default.
• W2023344075 countsByYear W20233440752023 @default.
• W2023344075 crossrefType "journal-article" @default.
• W2023344075 hasAuthorship W2023344075A5007171355 @default.
• W2023344075 hasAuthorship W2023344075A5015581163 @default.
• W2023344075 hasAuthorship W2023344075A5022226465 @default.
• W2023344075 hasAuthorship W2023344075A5025165307 @default.

• next