Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023346033> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2023346033 endingPage "Fa29" @default.
- W2023346033 startingPage "Fa29" @default.
- W2023346033 abstract "Research into treatment of stroke and neonatal hypoxic-ischaemic (HI) insult has been beset by high variability in clinical and histopathology outcome despite similar insult severity, necessitating large groups to produce significant results. This is a common problem across species in mice, rats, fetal chick, fetal sheep or newborn piglets and may impair translation of experimental results in clinical trials. Recent studies from our group using magnetic resonance spectroscopy (MRS) demonstrated that several injury biomarkers – Lactate to N-Acetyl Aspartate (Lac/NAA) and Lactate to Creatine (Lac/Cr) ratios in dorsal subcortical white matter (wm) and thalamus (th), as well as whole brain inorganic Phosphate to exchangeable Phosphate Pool (Pi/ePP) show secondary increase within 2–4 h after HI, with apparently almost linear trajectory. Using data sets from 2 large therapeutic neonatal piglet HI studies – Hypothermia&Xenon (1), and Methyl-Isobutyl-Amiloride (2) – we explored retrospectively whether (A) these early changes can predict MRS and histology (TUNEL, microglial deramification) outcome, and (B) affect statistical quality of the results. Overall, all 5 biomarkers (Pi/ePP, wmLac/Cr, wmLac/NAA, thLac/Cr, thLac/NAA) showed significant correlation with MRS and histology outcome in both studies, but this was particularly moderate for early Pi/ePP and high for thLac/NAA (see figure 1). Moreover, correction for the early thLac/Cr or thLac/NAA using actual/expected ratio revealed a significant difference for the combined Hypothermia&Xenon group versus that of hypothermia alone on most MRS and histology outcome measures. These data suggest that collecting early MRS biomarkers before onset of treatment could reduce variability and improve statistical impact of the final results." @default.
- W2023346033 created "2016-06-24" @default.
- W2023346033 creator A5012975235 @default.
- W2023346033 creator A5015882186 @default.
- W2023346033 creator A5036801866 @default.
- W2023346033 creator A5037156399 @default.
- W2023346033 creator A5065629292 @default.
- W2023346033 creator A5087206127 @default.
- W2023346033 creator A5087360866 @default.
- W2023346033 creator A5090217815 @default.
- W2023346033 date "2011-06-01" @default.
- W2023346033 modified "2023-09-27" @default.
- W2023346033 title "Use of 2-4 H magnetic resonance spectroscopy (MRS) biomarkers to predict 48 H MRS and histology outcome biomarkers in a piglet model of perinatal asphyxia" @default.
- W2023346033 doi "https://doi.org/10.1136/archdischild.2011.300164.43" @default.
- W2023346033 hasPublicationYear "2011" @default.
- W2023346033 type Work @default.
- W2023346033 sameAs 2023346033 @default.
- W2023346033 citedByCount "0" @default.
- W2023346033 crossrefType "journal-article" @default.
- W2023346033 hasAuthorship W2023346033A5012975235 @default.
- W2023346033 hasAuthorship W2023346033A5015882186 @default.
- W2023346033 hasAuthorship W2023346033A5036801866 @default.
- W2023346033 hasAuthorship W2023346033A5037156399 @default.
- W2023346033 hasAuthorship W2023346033A5065629292 @default.
- W2023346033 hasAuthorship W2023346033A5087206127 @default.
- W2023346033 hasAuthorship W2023346033A5087360866 @default.
- W2023346033 hasAuthorship W2023346033A5090217815 @default.
- W2023346033 hasConcept C126322002 @default.
- W2023346033 hasConcept C126838900 @default.
- W2023346033 hasConcept C142724271 @default.
- W2023346033 hasConcept C143409427 @default.
- W2023346033 hasConcept C170493617 @default.
- W2023346033 hasConcept C2777390192 @default.
- W2023346033 hasConcept C2779896295 @default.
- W2023346033 hasConcept C2779914510 @default.
- W2023346033 hasConcept C2780164069 @default.
- W2023346033 hasConcept C2780577055 @default.
- W2023346033 hasConcept C2781192897 @default.
- W2023346033 hasConcept C2989005 @default.
- W2023346033 hasConcept C42219234 @default.
- W2023346033 hasConcept C541997718 @default.
- W2023346033 hasConcept C544855455 @default.
- W2023346033 hasConcept C57742111 @default.
- W2023346033 hasConcept C61174792 @default.
- W2023346033 hasConcept C71924100 @default.
- W2023346033 hasConceptScore W2023346033C126322002 @default.
- W2023346033 hasConceptScore W2023346033C126838900 @default.
- W2023346033 hasConceptScore W2023346033C142724271 @default.
- W2023346033 hasConceptScore W2023346033C143409427 @default.
- W2023346033 hasConceptScore W2023346033C170493617 @default.
- W2023346033 hasConceptScore W2023346033C2777390192 @default.
- W2023346033 hasConceptScore W2023346033C2779896295 @default.
- W2023346033 hasConceptScore W2023346033C2779914510 @default.
- W2023346033 hasConceptScore W2023346033C2780164069 @default.
- W2023346033 hasConceptScore W2023346033C2780577055 @default.
- W2023346033 hasConceptScore W2023346033C2781192897 @default.
- W2023346033 hasConceptScore W2023346033C2989005 @default.
- W2023346033 hasConceptScore W2023346033C42219234 @default.
- W2023346033 hasConceptScore W2023346033C541997718 @default.
- W2023346033 hasConceptScore W2023346033C544855455 @default.
- W2023346033 hasConceptScore W2023346033C57742111 @default.
- W2023346033 hasConceptScore W2023346033C61174792 @default.
- W2023346033 hasConceptScore W2023346033C71924100 @default.
- W2023346033 hasIssue "Supplement 1" @default.
- W2023346033 hasLocation W20233460331 @default.
- W2023346033 hasOpenAccess W2023346033 @default.
- W2023346033 hasPrimaryLocation W20233460331 @default.
- W2023346033 hasRelatedWork W1483078828 @default.
- W2023346033 hasRelatedWork W2006132927 @default.
- W2023346033 hasRelatedWork W2023346033 @default.
- W2023346033 hasRelatedWork W2056348640 @default.
- W2023346033 hasRelatedWork W2071695907 @default.
- W2023346033 hasRelatedWork W2139404492 @default.
- W2023346033 hasRelatedWork W2209298909 @default.
- W2023346033 hasRelatedWork W2415026943 @default.
- W2023346033 hasRelatedWork W2625206756 @default.
- W2023346033 hasRelatedWork W66886384 @default.
- W2023346033 hasVolume "96" @default.
- W2023346033 isParatext "false" @default.
- W2023346033 isRetracted "false" @default.
- W2023346033 magId "2023346033" @default.
- W2023346033 workType "article" @default.