FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023348831> ?p ?o ?g. }

• W2023348831 endingPage "1096" @default.
• W2023348831 startingPage "1084" @default.
• W2023348831 abstract "COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including Cps35, the only essential subunit. Histone H2B monoubiquitination by Rad6/Bre1 is required for both H3K4 methylation by COMPASS, and H3K79 methylation by Dot1. However, the molecular mechanism for such histone crosstalk is poorly understood. Here, we demonstrate that histone H2B monoubiquitination controls the binding of Cps35 with COMPASS complex. Cps 35 is required for COMPASS' catalytic activity in vivo, and the addition of exogenous purified Cps35 to COMPASS purified from a Δrad6 background results in the generation of a methylation competent COMPASS. Cps35 associates with the chromatin of COMPASS-regulated genes in a H2BK123 monoubiquitination-dependent but Set1-independent manner. Cps35 is also required for proper H3K79 trimethylation. These findings offer insight into the molecular role of Cps35 in translating the H2B monoubiquitination signal into H3 methylation." @default.
• W2023348831 created "2016-06-24" @default.
• W2023348831 creator A5000363855 @default.
• W2023348831 creator A5006662998 @default.
• W2023348831 creator A5029331756 @default.
• W2023348831 creator A5034566006 @default.
• W2023348831 creator A5066900236 @default.
• W2023348831 creator A5079392980 @default.
• W2023348831 creator A5084946819 @default.
• W2023348831 creator A5086228456 @default.
• W2023348831 date "2007-12-01" @default.
• W2023348831 modified "2023-10-12" @default.
• W2023348831 title "Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS" @default.
• W2023348831 cites W1535395598 @default.
• W2023348831 cites W1575542444 @default.
• W2023348831 cites W1577230998 @default.
• W2023348831 cites W1597678601 @default.
• W2023348831 cites W1963545795 @default.
• W2023348831 cites W1963996414 @default.
• W2023348831 cites W1965343063 @default.
• W2023348831 cites W1969671007 @default.
• W2023348831 cites W1990299806 @default.
• W2023348831 cites W2002466684 @default.
• W2023348831 cites W2002879684 @default.
• W2023348831 cites W2003391080 @default.
• W2023348831 cites W2007839434 @default.
• W2023348831 cites W2008461545 @default.
• W2023348831 cites W2011824912 @default.
• W2023348831 cites W2014179038 @default.
• W2023348831 cites W2015477907 @default.
• W2023348831 cites W2019468853 @default.
• W2023348831 cites W2024615596 @default.
• W2023348831 cites W2026465178 @default.
• W2023348831 cites W2026501344 @default.
• W2023348831 cites W2029553332 @default.
• W2023348831 cites W2032601646 @default.
• W2023348831 cites W2035380835 @default.
• W2023348831 cites W2039778682 @default.
• W2023348831 cites W2039940539 @default.
• W2023348831 cites W2048613921 @default.
• W2023348831 cites W2051166632 @default.
• W2023348831 cites W2053894359 @default.
• W2023348831 cites W2056018903 @default.
• W2023348831 cites W2059180978 @default.
• W2023348831 cites W2059696301 @default.
• W2023348831 cites W2060875411 @default.
• W2023348831 cites W2069200751 @default.
• W2023348831 cites W2070372183 @default.
• W2023348831 cites W2070959297 @default.
• W2023348831 cites W2081022101 @default.
• W2023348831 cites W2083248748 @default.
• W2023348831 cites W2083548220 @default.
• W2023348831 cites W2089689396 @default.
• W2023348831 cites W2097081350 @default.
• W2023348831 cites W2097565373 @default.
• W2023348831 cites W2101085659 @default.
• W2023348831 cites W2101598171 @default.
• W2023348831 cites W2108014213 @default.
• W2023348831 cites W2109555420 @default.
• W2023348831 cites W2109818765 @default.
• W2023348831 cites W2116632435 @default.
• W2023348831 cites W2120478300 @default.
• W2023348831 cites W2127976626 @default.
• W2023348831 cites W2132440338 @default.
• W2023348831 cites W2133452708 @default.
• W2023348831 cites W2137001129 @default.
• W2023348831 cites W2139384923 @default.
• W2023348831 cites W2139633538 @default.
• W2023348831 cites W2151243189 @default.
• W2023348831 cites W2166829841 @default.
• W2023348831 cites W2170964470 @default.
• W2023348831 doi "https://doi.org/10.1016/j.cell.2007.09.046" @default.
• W2023348831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18083099" @default.
• W2023348831 hasPublicationYear "2007" @default.
• W2023348831 type Work @default.
• W2023348831 sameAs 2023348831 @default.
• W2023348831 citedByCount "373" @default.
• W2023348831 countsByYear W20233488312012 @default.
• W2023348831 countsByYear W20233488312013 @default.
• W2023348831 countsByYear W20233488312014 @default.
• W2023348831 countsByYear W20233488312015 @default.
• W2023348831 countsByYear W20233488312016 @default.
• W2023348831 countsByYear W20233488312017 @default.
• W2023348831 countsByYear W20233488312018 @default.
• W2023348831 countsByYear W20233488312019 @default.
• W2023348831 countsByYear W20233488312020 @default.
• W2023348831 countsByYear W20233488312021 @default.
• W2023348831 countsByYear W20233488312022 @default.
• W2023348831 countsByYear W20233488312023 @default.
• W2023348831 crossrefType "journal-article" @default.
• W2023348831 hasAuthorship W2023348831A5000363855 @default.
• W2023348831 hasAuthorship W2023348831A5006662998 @default.
• W2023348831 hasAuthorship W2023348831A5029331756 @default.
• W2023348831 hasAuthorship W2023348831A5034566006 @default.
• W2023348831 hasAuthorship W2023348831A5066900236 @default.
• W2023348831 hasAuthorship W2023348831A5079392980 @default.
• W2023348831 hasAuthorship W2023348831A5084946819 @default.
• W2023348831 hasAuthorship W2023348831A5086228456 @default.

• next