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- W2023349049 abstract "Eighty-two pediatric patients with Crohn’s disease received a total of 432 infusions of infliximab for treatment of their disease. The mean number of infusions per patient was 5.3 with a median of 3. As a measure of efficacy, corticosteroid use was evaluated. The mean age of the patients was 15.3 years. Eighty-four percent had colonic involvement, 78% had small bowel involvement, and 37% had perianal disease. The dose was 5 mg/kg. Of the 33 patients receiving corticosteroids when infliximab therapy was initiated, 26 achieved steroid independence at a median period of 12 weeks. Nine of the 26 experienced relapse and resumed corticosteroid therapy at a median time of 40 weeks from the first infusion and 8 weeks from the most recent infusion. Ultimately, 19 of the 33 patients (57.6%) had long-term improvement based on steroid usage. Twelve of these patients continue to receive infliximab infusions, and 7 were able to remain steroid free without further infusions. The main side adverse effect of infliximab was infusion reactions, which occurred in 5.3% of infusions. Three patients had herpes zoster and 1 had Listeria monocytogenes meningitis. No patients were shown to have delayed hypersensitivity reactions or malignancies." @default.
- W2023349049 created "2016-06-24" @default.
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- W2023349049 date "2004-05-01" @default.
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- W2023349049 title "Safety and steroid-sparing experience using infliximab for Crohn’s disease at a pediatric inflammatory bowel disease center" @default.
- W2023349049 doi "https://doi.org/10.1016/j.jpedsurg.2004.03.006" @default.
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