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- W2023350304 abstract "Objective: To evaluate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) on mouse embryo development and apoptosis.Design: Controlled animal study.Setting: Academic research environment.Animal(s): Female mice (CB6F1) at 3 to 6 weeks of age and proven breeders (C578B46).Intervention(s): Mouse embryos were obtained at the morula stage and cultured to the blastocyst stage in a pharmacologic dose of TCDD (3.1 μM) or a control medium. The morphology was assessed, and staining for apoptosis was performed. Immunohistochemistry for the presence of aromatic hydrocarbon receptor (AhR) was performed in another set of morula-stage embryos.Main Outcome Measure(s): The number of embryos developing from the morula to the blastocyst stage and number of apoptotic blastomeres in control vs. TCDD culture conditions.Result(s): No statistically significant differences were observed in the percentage of embryos reaching the blastocyst stage: 80.9% (115 of 142) in the TCDD-treated group, vs. 82.9% (121 of 146) in the control group. There was also no difference in the degree of apoptosis: 22.6 ± 7.3% apoptotic cells (TCDD) vs. 25.3 ± 9.7% (controls). Staining indicated the slight presence of aromatic hydrocarbon receptor in the morula-stage mouse embryos.Conclusion(s): TCDD at 3.1 μM did not alter the development of early mouse morula to blastocysts and did not significantly induce apoptosis in vitro." @default.
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- W2023350304 date "2001-06-01" @default.
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- W2023350304 title "Effects of dioxin, an environmental pollutant, on mouse blastocyst development and apoptosis" @default.
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- W2023350304 doi "https://doi.org/10.1016/s0015-0282(01)01802-7" @default.
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